武内謙憲 (Yoshinori Takeuchi) - 論文

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice

Matsuzaka, Takashi, Kuba, Motoko, Koyasu, Saori, Yamamoto, Yuta, Motomura, Kaori, Arulmozhiraja, Sundaram, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Okajima, Yuka, Han, Song-Iee, Aita, Yuichi, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Ema, Masatsugu, Takahashi, Satoru, Tokiwa, Hiroaki, Shimano, Hitoshi

Hepatology (Baltimore, Md.) 71(5) 1609 - 1625 2020年5月

Characterization of Osteoarthritis in a Medial Meniscectomy-Induced Animal Model Using Contrast-Enhanced X-ray Microtomography.

Takehito Sugasawa, Tomoaki Kuji, Kai Aoki, Koki Yanazawa, Akiko Takenouchi, Makoto Watanabe, Yoshiya Tome, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuhiro Shishikura, Seiko Ono, Yasuko Yoshida, Yasushi Kawakami, Kazuhiro Takekoshi

Biomedicines 8(3) 2020年3月10日

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1

Ma, Yang, Sekiya, Motohiro, Kainoh, Kenta, Matsuda, Takaaki, Iwasaki, Hitoshi, Osaki, Yoshinori, Sugano, Yoko, Suzuki, Hiroaki, Takeuchi, Yoshinori, Miyamoto, Takafumi, Yahagi, Naoya, Nakagawa, Yoshimi, Matsuzaka, Takashi, Shimano, Hitoshi

Biochemical and biophysical research communications 523(2) 354 - 360 2020年3月

The detection of trans gene fragments of hEPO in gene doping model mice by Taqman qPCR assay.

Kai Aoki, Takehito Sugasawa, Kouki Yanazawa, Koichi Watanabe, Tohru Takemasa, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuko Yoshida, Tomoaki Kuji, Nanami Sekine, Kaoru Takeuchi, Haruna Ueda, Yasushi Kawakami, Kazuhiro Takekoshi

PeerJ 8 e8595 2020年

Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR.

Takehito Sugasawa, Kai Aoki, Koichi Watanabe, Koki Yanazawa, Tohru Natsume, Tohru Takemasa, Kaori Yamaguchi, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuko Yoshida, Katsuyuki Tokinoya, Nanami Sekine, Kaoru Takeuchi, Haruna Ueda, Yasushi Kawakami, Satoshi Shimizu, Kazuhiro Takekoshi

Genes 10(6) E436 2019年6月8日

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

R, Sharma, T, Matsuzaka, MK, Kaushik, T, Sugasawa, H, Ohno, Y, Wang, K, Motomura, T, Shimura, Y, Okajima, Y, Mizunoe, Y, Ma, ZM, Saber, H, Iwasaki, S, Yatoh, H, Suzuki, Y, Aita, SI, Han, Y, Takeuchi, N, Yahagi, T, Miyamoto, M, Sekiya, Y, Nakagawa, H, Shimano

Scientific Reports 9(1) 5169 2019年3月査読有り

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

Murayama, Yuki, Yahagi, Naoya, Takeuchi, Yoshinori, Aita, Yuichi, Mehrazad Saber, Zahra, Wada, Nobuhiro, Li, EnXu, Piao, Xianying, Sawada, Yoshikazu, Shikama, Akito, Masuda, Yukari, Nishi-Tatsumi, Makiko, Kubota, Midori, Izumida, Yoshihiko, Miyamoto, Takafumi, Sekiya, Motohiro, Matsuzaka, Takashi, Nakagawa, Yoshimi, Sugano, Yoko, Iwasaki, Hitoshi, Kobayashi, Kazuto, Yatoh, Shigeru, Suzuki, Hiroaki, Yagyu, Hiroaki, Kawakami, Yasushi, Shimano, Hitoshi

FEBS letters 593(4) 423 - 432 2019年2月査読有り

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Motohiro Sekiya, Yoshimi Nakagawa, Hirohito Sone, Naoya Yahagi, Nobuhiro Yamada, Yoshikazu Higami, Hitoshi Shimano

Endocrinology 159(6) 2308 - 2323 2018年6月1日査読有り

Transgenic mice overexpressing SREBP-1a in male ob/ob mice exhibit lipodystrophy and exacerbate insulin resistance

Ohno, Hiroshi, Matsuzaka, Takashi, Tang, Nie, Sharma, Rahul, Motomura, Kaori, Shimura, Takuya, Satoh, Aoi, Han, Song-Iee, Takeuchi, Yoshinori, Aita, Yuichi, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sekiya, Motohiro, Nakagawa, Yoshimi, Sone, Hirohito, Yahagi, Naoya, Yamada, Nobuhiro, Higami, Yoshikazu, Shimano, Hitoshi

Endocrinology 2018年6月査読有り

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes

Xianying Piao, Naoya Yahagi, Yoshinori Takeuchi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Yoshihiko Izumida, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Hitoshi Shimano

FEBS Letters 592(3) 422 - 433 2018年2月1日

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes

Xianying Piao, Naoya Yahagi, Yoshinori Takeuchi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Yoshihiko Izumida, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Hitoshi Shimano

FEBS Letters 592(3) 422 - 433 2018年2月1日査読有り

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry

Yoshikazu Sawada, Yoshihiko Izumida, Yoshinori Takeuchi, Yuichi Aita, Nobuhiro Wada, EnXu Li, Yuki Murayama, Xianying Piao, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Takashi Kadowaki, Hitoshi Shimano, Naoya Yahagi

Biochemical and Biophysical Research Communications 493(1) 40 - 45 2017年11月4日

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Zhao, Hui, Matsuzaka, Takashi, Nakano, Yuta, Motomura, Kaori, Tang, Nie, Yokoo, Tomotaka, Okajima, Yuka, Han, Song-Iee, Takeuchi, Yoshinori, Aita, Yuichi, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sekiya, Motohiro, Yahagi, Naoya, Nakagawa, Yoshimi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi

Diabetes 66(7) 1833 - 1846 2017年7月1日

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Zhao, Hui, Matsuzaka, Takashi, Nakano, Yuta, Motomura, Kaori, Tang, Nie, Yokoo, Tomotaka, Okajima, Yuka, Han, Song-Iee, Takeuchi, Yoshinori, Aita, Yuichi, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sekiya, Motohiro, Yahagi, Naoya, Nakagawa, Yoshimi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi

Diabetes 66(7) 1833 - 1846 2017年7月

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Makiko Nishi-Tatsumi, Naoya Yahagi, Yoshinori Takeuchi, Naoki Toya, Ayako Takarada, Yuki Murayama, Yuichi Aita, Yoshikazu Sawada, Xiaoying Piao, Yukari Oya, Akito Shikama, Yukari Masuda, Midori Kubota, Yoshihiko Izumida, Takashi Matsuzaka, Yoshimi Nakagawa, Motohiro Sekiya, Yoko Iizuka, Yasushi Kawakami, Takashi Kadowaki, Nobuhiro Yamada, Hitoshi Shimano

FEBS LETTERS 591(7) 965 - 978 2017年4月

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Makiko Nishi-Tatsumi, Naoya Yahagi, Yoshinori Takeuchi, Naoki Toya, Ayako Takarada, Yuki Murayama, Yuichi Aita, Yoshikazu Sawada, Xiaoying Piao, Yukari Oya, Akito Shikama, Yukari Masuda, Midori Kubota, Yoshihiko Izumida, Takashi Matsuzaka, Yoshimi Nakagawa, Motohiro Sekiya, Yoko Iizuka, Yasushi Kawakami, Takashi Kadowaki, Nobuhiro Yamada, Hitoshi Shimano

FEBS LETTERS 591(7) 965 - 978 2017年4月

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

Takuya Kikuchi, Kana Orihara, Fusaka Oikawa, Song-iee Han, Motoko Kuba, Kanako Okuda, Aoi Satoh, Yoshinori Osaki, Yoshinori Takeuchi, Yuichi Aita, Takashi Matsuzaka, Hitoshi Iwasaki, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hiroaki Suzuki, Hirohito Sone, Yoshimi Nakagawa, Nobuhiro Yamada, Hitoshi Shimano

MOLECULAR METABOLISM 5(11) 1092 - 1102 2016年11月

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Xiaoying Piao, Naoki Toya, Yukari Oya, Akito Shikama, Ayako Takarada, Yukari Masuda, Makiko Nishi, Midori Kubota, Yoshihiko Izumida, Takashi Yamamoto, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Osamu Urayama, Yasushi Kawakami, Yoko Iizuka, Takanari Gotoda, Keiji Itaka, Kazunori Kataoka, Ryozo Nagai, Takashi Kadowaki, Nobuhiro Yamada, Yuan Lu, Mukesh K. Jain, Hitoshi Shimano

CELL REPORTS 16(9) 2373 - 2386 2016年8月査読有り

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.

Suzuki-Kemuriyama,N, Matsuzaka,T, Kuba,M, Ohno,H, Han,SI, Takeuchi,Y, Isaka,M, Kobayashi,K, Iwasaki,H, Yatoh,S, Suzuki,H, Miyajima,K, Nakae,D, Yahagi,N, Nakagawa,Y, Sone,H, Yamada,N, Shimano,Hitoshi

PLoS One. 11(6) e0157580 2016年6月査読有り

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

Motoko Kuba, Takashi Matsuzaka, Rie Matsumori, Ryo Saito, Naoko Kaga, Hikari Taka, Kei Ikehata, Naduki Okada, Takuya Kikuchi, Hiroshi Ohno, Song-Iee Han, Yoshinori Takeuchi, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Naoya Yahagi, Yoji Arakawa, Tsutomu Fujimura, Yoshimi Nakagawa, Nobuhiro Yamada, Hitoshi Shimano

SCIENTIFIC REPORTS 5 2015年12月査読有り