許東洙 (Dong-Zhu XU) - マイポータル

基本情報

所属: 筑波大学医学医療系准教授

学位: 博士（医学）(2011年3月筑波大学)

J-GLOBAL ID: 201801018488258197
researchmap会員ID: 7000024551

研究キーワード

AMED橋渡し研究戦略的推進プログラム(シーズA)

研究分野

ライフサイエンス / 循環器内科学 /

経歴

2023年12月 - 現在

Indiana University School of Medicine, Division of Cardiovascular Medicine, Research Faulty
2018年7月 - 現在

筑波大学, 医学医療系循環器内科, 准教授
2015年10月 - 2018年6月

Indiana University School of Medicine, Krannert Institute of Cardiology, Research fellow
2011年4月 - 2017年12月

筑波大学, 医学医療系循環器内科, 助教
1999年 - 2001年

中国吉林省延吉市立病院, 内科, 医師

学歴

2007年4月 - 2011年3月

筑波大学, 人間総合科学研究科, 疾患制御医学循環器内科学

受賞

2006年

文部科学省国費留学生, 文部科学省

許東洙

論文

Cytokine profiling of patients with immune checkpoint inhibitor-associated myocarditis: a pilot study

Li, Siqi, Tajiri, Kazuko, Ishizuka, Yuki, Murakata, Yoshiko, Yuan, Zixun, Xu, Dongzhu, Murakoshi, Nobuyuki, Ishizu, Tomoko

MOLECULAR BIOLOGY REPORTS 52(1) 2025年10月査読有り
BET Inhibitor JQ1 Attenuates Atrial Fibrillation Through Modulation of Fibrosis, Calcium Homeostasis, and Mitochondrial Function in a Murine Model

Song, Zonghu, Murakoshi, Nobuyuki, Xu, Dongzhu, Xi, Binyang, Murakata, Yoshiko, Aonuma, Kazuhiro, Tajiri, Kazuko, Ishizu, Tomoko

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26(21) 2025年10月査読有り
Transforming Human Amniotic Membrane into Nanoparticles: An Approach for Cardiac Delivery Systems

Stellpflug, Austin, Li, Siqi, Wan, Tina, Mattern, Carol, Nguyen, Christopher, Xu, Dongzhu, Han, Lu, Wang, Bo

ACS APPLIED BIO MATERIALS 2025年8月査読有り
Editorial: Recent advances in causes, diagnosis, and therapeutics for congenital heart defects

Xu, Xinxiu, Lo, Cecilia W., Martin, Lisa J., Han, Lu, Xu, Dongzhu

FRONTIERS IN GENETICS 16 2025年2月査読有り
4E-BP3 deficiency impairs dendritic cell activation and CD4⁺ T cell differentiation and attenuates α-myosin-specific T cell-mediated myocarditis in mice

Li, Siqi, Tajiri, Kazuko, Yuan, Zixun, Murakata, Yoshiko, Song, Zonghu, Mizuno, Seiya, Xu, Dongzhu, Murakoshi, Nobuyuki

BASIC RESEARCH IN CARDIOLOGY Epub 2024年11月査読有り
Autoantibody profiling of patients with immune checkpoint inhibitor-associated myocarditis: a pilot study

Li, Siqi, Xu, Dongzhu, Murakoshi, Nobuyuki, Yuan, Zixun, Imaoka, Takuro, Tajiri, Kazuko

FRONTIERS IN IMMUNOLOGY 15 1423622-1423622 2024年9月査読有り
Genetic testing and human leukocyte antigen in patients with hypertrophic cardiomyopathy and connective tissue diseases

Hiraya, Daigo, Murakoshi, Nobuyuki, Igarashi, Miyako, Xu, DongZhu, Ishizu, Tomoko

FRONTIERS IN GENETICS 15 2024年8月査読有り
Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation

Mori, Haruka, Xu, Dongzhu, Shimoda, Yuzuno, Yuan, Zixun, Murakata, Yoshiko, Xi, Binyang, Sato, Kimi, Yamamoto, Masayoshi, Tajiri, Kazuko, Ishizu, Tomoko …

Scientific reports 14(1) 15422-15422 2024年7月査読有り
An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice

Okabe, Yuta, Murakoshi, Nobuyuki, Kurebayashi, Nagomi, Inoue, Hana, Ito, Yoko, Murayama, Takashi, Miyoshi, Chika, Funato, Hiromasa, Ishii, Koichiro, Xu, Dongzhu …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121(17) 2024年4月査読有り
Early Detection and Prediction of Anthracycline-Induced Cardiotoxicity - A Prospective Cohort Study

Inoue, Keiko, Machino-Ohtsuka, Tomoko, Nakazawa, Yoko, Iida, Noriko, Sasamura, Rumi, Bando, Hiroko, Chiba, Shigeru, Tasaka, Nobutaka, Ishizu, Tomoko, Murakoshi, Nobuyuki …

Circulation journal : official journal of the Japanese Circulation Society 88(5) 2024年4月
Impact of isorhamnetin for suppression of action potential aberrations associated with atrial fibrillation

Aonuma, K, Xu, D, Murakoshi, N, Tajiri, K, Yuan, Z, Murakata, Y, Tominaga, K, Nogami, A, Aonuma, K, Isoda, H

EUROPEAN HEART JOURNAL 44(2) 2023年11月査読有り
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Aonuma, Kazuhiro, Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Okabe, Yuta, Yuan, Zixun, Li, Siqi, Murakata, Yoshiko, Tominaga, Kenichi, Nogami, Akihiko …

Clinical science (London, England : 1979) 136(24) 1831-1849 2022年12月22日
ASO Visual Abstract: Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation in Patients with Cancer: A Meta-analysis

Inoue, Keiko, Tajiri, Kazuko, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Annals of surgical oncology 30(2) 723-724 2022年11月17日
Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation for Patients with Cancer: A Meta-Analysis

Inoue, Keiko, Tajiri, Kazuko, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Annals of surgical oncology 30(2) 711-721 2022年10月22日査読有り
Identification of potential dilated cardiomyopathy-related targets by meta-analysis and co-expression analysis of human RNA-sequencing datasets

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Tajiri, Kazuko, Okabe, Yuta, Aonuma, Kazuhiro, Murakata, Yoshiko, Li, Siqi, Song, Zonghu, Shimoda, Yuzuno …

Life sciences 306 120807-120807 2022年7月13日
Editorial: Directing Stem Cell Fate Using Plant Extracts and Their Bioactive Compounds

Ferdousi, Farhana, Sasaki, Kazunori, Xu, Dongzhu, Zheng, Yun-Wen, Szele, Francis G., Isoda, Hiroko

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10 2022年6月査読有り
Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation

Shimoda, Yuzuno, Murakoshi, Nobuyuki, Mori, Haruka, Xu, DongZhu, Tajiri, Kazuko, Hemmi, Yasuko, Sato, Iori, Noguchi, Michiya, Nakamura, Yukio, Hayashi, Yohei …

Stem Cell Research 62 102793-102793 2022年4月14日
Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy

Murakata, Yoshiko, Yamagami, Fumi, Murakoshi, Nobuyuki, Xu, DongZhu, Song, Zhonghu, Li, Siqi, Okabe, Yuta, Aonuma, Kazuhiro, Yuan, ZiXun, Mori, Haruka …

Frontiers in cardiovascular medicine 9 1075358-1075358 2022年4月1日
Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy

Murakata, Yoshiko, Yamagami, Fumi, Murakoshi, Nobuyuki, Xu, DongZhu, Song, Zhonghu, Li, Siqi, Okabe, Yuta, Aonuma, Kazuhiro, Yuan, ZiXun, Mori, Haruka …

Frontiers in cardiovascular medicine 9 1075358-1075358 2022年4月
Right bundle branch block and risk of cardiovascular mortality: the Ibaraki Prefectural Health Study

Nakazawa, Naomi, Ishizu, Tomoko, Sairenchi, Toshimi, Yamagishi, Kazumasa, Murakoshi, Nobuyuki, Nakagawa, Daishi, Nakatsukasa, Tomofumi, Kawamatsu, Naoto, Sato, Kimi, Yamamoto, Masayoshi …

HEART AND VESSELS Epub 2021年9月査読有り

もっとみる

書籍等出版物

Directing stem cell fate using plant extracts and their bioactive compounds

Isoda, Hiroko, Szele, Francis G, Zheng, Yun-Wen, Xu, DongZhu, Sasaki, Kazunori, Ferdousi, Farhana

FRONTIERS MEDIA SA 2023年 (ISBN: 9782832511848)
Atrial fibrillation rat model induced by transvenous catheter pacing and PPAR-γ activator as upstream therapy for age-related atrial fibrillation

許, 東洙

2011年3月

講演・口頭発表等

EIF4EBP1 Deletion Ameliorates Ischemic Heart Failure Development After Myocardial Infarction

XI, Binyang, MURAKOSHI, Nobuyuki, XU, Dongzhu, LIU, Jiaqi, TAO, Zheng, ISHIZU, Tomoko

第89回日本循環器学会学術集会
Programmed Cell Death-Ligand 2 deficiency improves heart failure after myocardial infarction

LIU, Jiaqi, MURAKOSHI, Nobuyuki, XU, Dongzhu, XI, Binyang, ISHIZU, Tomoko

第89回日本循環器学会学術集会
EIF4EBP1 Deletion Ameliorates Heart Failure Progression After Myocardial Infarction

XI, Binyang, MURAKOSHI, Nobuyuki, XU, Dongzhu, LIU, Jiaqi, TAO, Zheng, ISHIZU, Tomoko

CVWM2024
Programmed Cell Death-Ligand 2 deletion ameliorates ischemic heart failure development after myocardial infarction

LIU, Jiaqi, MURAKOSHI, Nobuyuki, XU, Dongzhu, XI, Binyang, ISHIZU, Tomoko

CVWM2024
LMNA遺伝子短縮型変異を有する拡張型心筋症患者由来 iPS 細胞の樹立と誘導心筋の解析

竹尾麻耶, 村越, 伸行, 許東洙, 下田柚須乃, 石津智子

第47回日本分子生物学会年会
全国の急性心筋梗塞患者に対する医療機関毎の外来心臓リハビリテーションの勧奨及び導入実態

小宮山, 潤, 杉山, 雄大, 川松, 直人, 加藤, 秀典, 孫, 瑜, 許, 東洙, 田宮, 菜奈子

第30回日本心臓リハビリテーション学会学術集会
LMNA 変異を有する拡張型心筋症患者由来 iPS 細胞の樹立と病態解析

竹尾摩耶, 許東洙, 席彬洋, 石津智子, 村越, 伸行

第10回日本心筋症研究会
The effect of BET inhibitor on pathogenesis of atrial fibrillation

Song, Zonghu, MURAKOSHI, Nobuyuki, Xu, Dongzhu, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Tajiri, Kazuko, Haruka Mori, Nogami, Akihiko, Ieda, Masaki

第88回日本循環器学会学術集会
Early Detection and Prediction of Anthracycline-Induced Cardiotoxicity ― A Prospective Cohort Study ―

Keiko, Inoue, Tomoko, Machino-Ohtsuka, Yoko, Nakazawa, Noriko, Iida, Rumi, Sasamura, Hiroko, Bando, Shigeru, Chiba, Nobutaka, Tasaka, Tomoko, Ishizu, 村越, 伸行, Dongzhu, Xu, Ikuo, Sekine, Kazuko, Tajiri

第88回日本循環器学会学術集会
Phenotype-Driven Forward Genetics Identifies a Novel Mouse Model of Inherited Arrhythmia with Spontaneous Sudden Cardiac Death

Okabe, Yuta, MURAKOSHI, Nobuyuki, Ito, Yoko, Miyoshi, Chika, Funato, Hiromasa, Ishii, Koichiro, Inoue, Hana, Murayama, Takashi, Kurebayashi, Nagomi, Xu, Dongzhu, Aonuma, Kazuhiro, Wakana, Shigeharu, Yokoyama, Utako, Sakurai, Takashi, Ieda, Masaki, Yanagisawa, Masashi

American Heart Association Scientific Session 2023
Impact of isorhamnetin for suppression of action potential aberrations associated with atrial fibrillation

Aonuma, K, Xu, D, Murakoshi, N, Tajiri, K, Yuan, Z, Murakata, Y, Tominaga, K, Nogami, A, Aonuma, K, Isoda, H

Annual Meeting of the European-Society-of-Cardiology (ESC)
4E-BP3 Deficiency Ameliorates the Development of Autoimmune Myocarditis in Mice

Siqi, Li, Dongzhu, Xu, Kazuko, Tajiri, 村越, 伸行

North American Meeting of the International Society of Heart Research 2023
4E-BP3 Deficiency Ameliorates the Development of Autoimmune Myocarditis in Mice.

SIQI, LI, 許, 東洙, Kazuko, Tajiri, Nobuyuki, Murakoshi

NORTH AMERICAN MEETING OF THE INTERNATIONAL SOCIETY OF HEART RESEARCH
The effect of BET inhibitor on pathogenesis of atrial fibrillation

Song, Zonghu, Murakoshi, Nobuyuki, Xu, Dongzhu, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Okabe, Yuta, Mori, Haruka, Tajiri, Kazuko, Ieda, Masaki

第87回日本循環器学会学術集会
Molecular Mechanisms of a Newly Established Inherited Arrhythmia Mouse Model and Its Clinical Application

岡部, 雄太, 村越, 伸行, 井藤, 葉子, 三好, 千香, 船戸, 弘正, 石井, 光一郎, 井上, 華, 村山, 尚, 呉林, なごみ, 許, 東洙, 青沼, 和宏, 若菜, 茂晴, 横山, 詩子, 櫻井, 隆, 家田, 真樹, 柳沢, 正史

第87回日本循環器学会学術集会
Deletion of EIF4EBP3 prevents heart failure progression through maintaining mitochondrial function

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Tajiri, Kazuko, Li, Siqi, Murakata, Yoshiko, Okabe, Yuta, Song, Zonghu, Mori, Haruka, Ieda, Masaki

第87回日本循環器学会学術集会
The therapeutic effect of BET inhibitor on atrial fibrillation

Song, Zonghu, Murakoshi, Nobuyuki, Xu, Dongzhu, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Tajiri, Kazuko, Nogami, Akihiko, Ieda, Masaki

Cardiovascular Metabolic Week (CVMW) 2022
Generation and Analyses of iPSC-derived Cardiomyocytes from a Dilated Phase Hypertrophic Cardiomyopathic Patient Carrying MYBPC3 Frameshift Mutation

Mori, Haruka, Murakoshi, Nobuyuki, Shimoda, Yuzuno, Xu, DongZhu, Kobayashi, Kazuma, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Song, Zonghu, Aonuma, Kazuhiro, Ieda, Masaki

第26回日本心不全学会
Underlying mechanisms Related with Heart Failure are Identified by Meta-Analysis and Consensus Analysis of RNA-sequencing

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Li, Siqi, Murakata, Yoshiko, Song, Zonghu, Mori, Haruka, Ieda, Masaki

第26回日本心不全学会
Heart Failure related Potential Key Molecule was Identified by Human RNA-sequencing datasets and Mouse Model

Yuan, Zixun, Murakoshi, Nobuyuki, Murakoshi, Nobuyuki, Xu, Dongzhu, Li, Siqi, Murakata, Yoshiko, Song, Zonghu, Mori, Haruka, Ieda, Masaki

第26回日本心不全学会

もっとみる

所属学協会

2012年8月 - 現在

日本心臓電気生理学会
2007年 - 現在

日本循環器学会
2005年8月 - 現在

日本プライマリ・ケア連合学会

共同研究・競争的資金等の研究課題

AMED橋渡し研究戦略的推進プログラム(シーズA)

国立研究開発法人日本医療研究開発機構 2021年4月 - 2022年3月
心房細動細動発症におけるNampt役割の解明（国際共同研究強化）

文部科学省平成27年度国際共同研究加速基金（国際共同研究強化）国際共同研究加速基金(国際共同研究強化) 2016年 - 2018年

許東洙
肥満による心房細動発症機序の解明

日本学術振興会若手研究(B) 若手研究(B) 2012年 - 2013年

許東洙
不整脈の発症機序解明と治療