Xu Dong-Zhu - My portal

Profile Information

Affiliation: Associate Professor, Institute of Medicine, University of Tsukuba

Degree: Ph.D.(Mar, 2011, University of Tsukuba)

J-GLOBAL ID: 201801018488258197
researchmap Member ID: 7000024551

Research Interests

AMED橋渡し研究戦略的推進プログラム(シーズA)

Research Areas

Life sciences / Cardiology /

Research History

Dec, 2023 - Present

Research Faulty, Division of Cardiovascular Medicine, Indiana University School of Medicine
Jul, 2018 - Present

Faculty of Medicine, University of Tsukuba
Oct, 2015 - Jun, 2018

Research fellow, Krannert Institute of Cardiology, Indiana University School of Medicine
Apr, 2011 - Dec, 2017

University of Tsukuba
1999 - 2001

医師, 内科, 中国吉林省延吉市立病院

Education

Apr, 2007 - Mar, 2011

Cardiovascular Division Institute of Clinical Medicine, Graduate School, Division of Medicine, University of Tsukuba

Awards

2006

文部科学省国費留学生, 文部科学省

許東洙

Papers

Early Detection and Prediction of Anthracycline-Induced Cardiotoxicity　- A Prospective Cohort Study

Inoue, Keiko, Machino-Ohtsuka, Tomoko, Nakazawa, Yoko, Iida, Noriko, Sasamura, Rumi, Bando, Hiroko, Chiba, Shigeru, Tasaka, Nobutaka, Ishizu, Tomoko, Murakoshi, Nobuyuki …

Circulation journal : official journal of the Japanese Circulation Society, Mar, 2024
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Aonuma, Kazuhiro, Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Okabe, Yuta, Yuan, Zixun, Li, Siqi, Murakata, Yoshiko, Tominaga, Kenichi, Nogami, Akihiko …

Clinical science (London, England : 1979), 136(24) 1831-1849, Dec 22, 2022
ASO Visual Abstract: Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation in Patients with Cancer: A Meta-analysis

Inoue, Keiko, Tajiri, Kazuko, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Annals of surgical oncology, 30(2) 723-724, Nov 17, 2022
Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation for Patients with Cancer: A Meta-Analysis

Inoue, Keiko, Tajiri, Kazuko, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Annals of surgical oncology, 30(2) 711-721, Oct 22, 2022 Peer-reviewed
Identification of potential dilated cardiomyopathy-related targets by meta-analysis and co-expression analysis of human RNA-sequencing datasets

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Tajiri, Kazuko, Okabe, Yuta, Aonuma, Kazuhiro, Murakata, Yoshiko, Li, Siqi, Song, Zonghu, Shimoda, Yuzuno …

Life sciences, 306 120807-120807, Jul 13, 2022
Editorial: Directing Stem Cell Fate Using Plant Extracts and Their Bioactive Compounds

Ferdousi, Farhana, Sasaki, Kazunori, Xu, Dongzhu, Zheng, Yun-Wen, Szele, Francis G, Isoda, Hiroko

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, Jun, 2022 Peer-reviewed
Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation

Shimoda, Yuzuno, Murakoshi, Nobuyuki, Mori, Haruka, Xu, DongZhu, Tajiri, Kazuko, Hemmi, Yasuko, Sato, Iori, Noguchi, Michiya, Nakamura, Yukio, Hayashi, Yohei …

Stem Cell Research, 62 102793-102793, Apr 14, 2022
Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy

Murakata, Yoshiko, Yamagami, Fumi, Murakoshi, Nobuyuki, Xu, DongZhu, Song, Zhonghu, Li, Siqi, Okabe, Yuta, Aonuma, Kazuhiro, Yuan, ZiXun, Mori, Haruka …

Frontiers in cardiovascular medicine, 9 1075358-1075358, Apr 1, 2022
Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy

Murakata, Yoshiko, Yamagami, Fumi, Murakoshi, Nobuyuki, Xu, DongZhu, Song, Zhonghu, Li, Siqi, Okabe, Yuta, Aonuma, Kazuhiro, Yuan, ZiXun, Mori, Haruka …

Frontiers in cardiovascular medicine, 9 1075358-1075358, Apr, 2022
Right bundle branch block and risk of cardiovascular mortality: the Ibaraki Prefectural Health Study

Nakazawa, Naomi, Ishizu, Tomoko, Sairenchi, Toshimi, Yamagishi, Kazumasa, Murakoshi, Nobuyuki, Nakagawa, Daishi, Nakatsukasa, Tomofumi, Kawamatsu, Naoto, Sato, Kimi, Yamamoto, Masayoshi …

HEART AND VESSELS, Epub, Sep, 2021 Peer-reviewed
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Duo, Feng, Okabe, Yuta, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Song, Zhonghu …

Clinical science (London, England : 1979), 135(20) 2409-2422, Aug 13, 2021 Peer-reviewed
Loss of nocturnal dipping pattern of skin sympathetic nerve activity during and following an extended-duration work shift in residents in training

Chen, Mu, Sun, Jian, Chen, Tai-Zhong, Xu, Dong-Zhu, Wan, Juyi, Wang, Qunshan, Li, Yi-Gang

Journal of cardiology, 78(6) 509-516, Jul, 2021 Peer-reviewed
Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice

Li, Siqi, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, DongZhu, Yonebayashi, Saori, Okabe, Yuta, Yuan, Zixun, Feng, Duo, Inoue, Keiko, Aonuma, Kazuhiro …

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3), Feb, 2021 Peer-reviewed
Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice

Ogura, Yukino, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, DongZhu, Yonebayashi, Saori, Li, Siqi, Okabe, Yuta, Feng, Duo, Shimoda, Yuzuno, Song, Zoughu …

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(2), Jan, 2021 Peer-reviewed
MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, Dongzhu, Li, Siqi, Feng, Duo, Okabe, Yuta, Yuan, Zixun, Song, Zonghu, Aonuma, Kazuhiro …

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24(24) 14481-14490, Nov, 2020 Peer-reviewed
Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells and Its Cardioprotective Effects

Aonuma, Kazuhiro, Ferdousi, Farhana, Xu, DongZhu, Tominaga, Kenichi, Isoda, Hiroko

Frontiers in cell and developmental biology, 8, Sep, 2020 Peer-reviewed
Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway

Feng, Duo, Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Qin, Rujie, Yonebayashi, Saori, Okabe, Yuta, Li, Siqi, Yuan, Zixun, Aonuma, Kazutaka …

International journal of molecular sciences, 21(13), Jun, 2020 Peer-reviewed
Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes

Chen, Mu, Wang, Qunshan, Sun, Jian, Zhang, Peng-Pai, Li, Wei, Zhang, Rui, Mo, Bin-Feng, Chen, Tai-Zhong, Wan, Juyi, Xu, Dong-Zhu …

Journal of interventional cardiology, 2020, Apr, 2020 Peer-reviewed
Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts

Yin, Dechun, Yang, Na, Tian, Zhipeng, Wu, Adonis Z, Xu, Dongzhu, Chen, Mu, Kamp, Nicholas J, Wang, Zhuo, Shen, Changyu …

Heart rhythm, 17(2) 332-340, Sep, 2019 Peer-reviewed
Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice

Qin, Rujie, Murakoshi, Nobuyuki, Xu, DongZhu, Tajiri, Kazuko, Feng, Duo, Stujanna, Endin N, Yonebayashi, Saori, Nakagawa, Yoshimi, Shimano, Hitoshi …

Physiological reports, 7(4) e13972, Feb, 2019 Peer-reviewed

Books and Other Publications

Directing stem cell fate using plant extracts and their bioactive compounds

Isoda, Hiroko, Szele, Francis G, Zheng, Yun-Wen, Xu, DongZhu, Sasaki, Kazunori, Ferdousi, Farhana

FRONTIERS MEDIA SA, 2023 (ISBN: 9782832511848)
Atrial fibrillation rat model induced by transvenous catheter pacing and PPAR-γ activator as upstream therapy for age-related atrial fibrillation

Kyo,Tosyu

Mar, 2011

Presentations

4E-BP3 Deficiency Ameliorates the Development of Autoimmune Myocarditis in Mice.

SIQI, LI, 許, 東洙, Kazuko, Tajiri, Nobuyuki, Murakoshi

NORTH AMERICAN MEETING OF THE INTERNATIONAL SOCIETY OF HEART RESEARCH
The effect of BET inhibitor on pathogenesis of atrial fibrillation

Song, Zonghu, Murakoshi, Nobuyuki, Xu, Dongzhu, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Okabe, Yuta, Mori, Haruka, Tajiri, Kazuko, Ieda, Masaki

第87回日本循環器学会学術集会
Molecular Mechanisms of a Newly Established Inherited Arrhythmia Mouse Model and Its Clinical Application

岡部, 雄太, 村越, 伸行, 井藤, 葉子, 三好, 千香, 船戸, 弘正, 石井, 光一郎, 井上, 華, 村山, 尚, 呉林, なごみ, 許, 東洙, 青沼, 和宏, 若菜, 茂晴, 横山, 詩子, 櫻井, 隆, 家田, 真樹, 柳沢, 正史

第87回日本循環器学会学術集会
Deletion of EIF4EBP3 prevents heart failure progression through maintaining mitochondrial function

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Tajiri, Kazuko, Li, Siqi, Murakata, Yoshiko, Okabe, Yuta, Song, Zonghu, Mori, Haruka, Ieda, Masaki

第87回日本循環器学会学術集会
The therapeutic effect of BET inhibitor on atrial fibrillation

Song, Zonghu, Murakoshi, Nobuyuki, Xu, Dongzhu, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Tajiri, Kazuko, Nogami, Akihiko, Ieda, Masaki

Cardiovascular Metabolic Week (CVMW) 2022
Generation and Analyses of iPSC-derived Cardiomyocytes from a Dilated Phase Hypertrophic Cardiomyopathic Patient Carrying MYBPC3 Frameshift Mutation

Mori, Haruka, Murakoshi, Nobuyuki, Shimoda, Yuzuno, Xu, DongZhu, Kobayashi, Kazuma, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Song, Zonghu, Aonuma, Kazuhiro, Ieda, Masaki

第26回日本心不全学会
Underlying mechanisms Related with Heart Failure are Identified by Meta-Analysis and Consensus Analysis of RNA-sequencing

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Li, Siqi, Murakata, Yoshiko, Song, Zonghu, Mori, Haruka, Ieda, Masaki

第26回日本心不全学会
Heart Failure related Potential Key Molecule was Identified by Human RNA-sequencing datasets and Mouse Model

Yuan, Zixun, Murakoshi, Nobuyuki, Murakoshi, Nobuyuki, Xu, Dongzhu, Li, Siqi, Murakata, Yoshiko, Song, Zonghu, Mori, Haruka, Ieda, Masaki

第26回日本心不全学会
Heart Failure-related Potential Molecule Identified by Bioinformatics analysis and Mouse Model

袁梓勛, 村越, 伸行, 許, 東洙, 田尻, 和子, 李, 思琪, 村方, 好子, 岡部, 雄太, 宋, 宗虎, 下田, 柚須乃, 森, 遥香, 青沼, 和宏, 家田, 真樹

第8回日本心筋症研究会
LMNA遺伝子変異に起因する拡張型心筋症患者由来iPS細胞の樹立と病態モデルの作製

下田, 柚須乃, 村越, 伸行, 森, 遥香, 小林, 和真, 田尻, 和子, 許, 東洙, 佐藤, 伊織, 辺見, 康子, 林, 洋平, 家田, 真樹

第21回日本再生医療学会総会, Mar 17, 2022
Cardiomyopathy-Related Hub Genes and Upstream Regulators by Meta-analysis of RNA-Sequencing datasets

袁, 梓勛, 村越, 伸行, 許, 東洙, 田尻, 和子, 岡部, 雄太, 李, 思琪, 馮, 鐸, 米林, 沙織, 青沼, 和宏, 宋, 宗虎, 下田, 柚須乃, 家田, 真樹

第86回日本循環器学会学術集会, Mar 13, 2022
Establishment of induced pluripotent stem cell lines derived from dilated cardiomyopathic patients with LMNA mutations and generation of pathological models

Shimoda, Yuzuno, Murakoshi, Nobuyuki, Mori, Haruka, Kobayashi, Kazuma, Tajiri, Kazuko, Xu, DongZhu, Sato, Iori, Hemmi, Yasuko, Hayashi, Yohei, Ieda, Masaki

CiRA 2022 International Symposium, Feb 16, 2022
Natural compound Isorhamnetin Inhibits Angiotensin II-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice

Aonuma, Kazuhiro, Dong-Zhu , Xu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Okabe, Yuta, Yonebayashi, Saori, Yuan, Zixun, Li, Siqi, Aonuma, Kazutaka, Ieda, Masaki, Isoda, Hiroko

THE 85TH ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, Mar 26, 2021
PD-L2 Immune Checkpoint Protein Protects Against Autoimmune Myocarditis in Mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

第85回日本循環器学会学術集会, Mar 26, 2021
4E-BP3 Deficiency Attenuates Cardiac Inflammation in Mice with Experimental Autoimmune Myocarditis

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

第85回日本循環器学会学術集会, Mar 26, 2021
PD-L2 Protects Against Autoreactive CD4+ T-cell Expansion and Inflammation in Autoimmune Myocarditis in Mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Okabe, Yuta, Song, Zonghu, Shimoda, Yuzuno, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

CVMW2020, Mar 12, 2021
Isorhamnetin Reverses Angiotensin II-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice

Dong-Zhu , Xu, Aonuma, Kazuhiro, Murakoshi, Nobuyuki, Tajiri, Kazuko, Tominaga, Kenichi, Ieda, Masaki, Isoda, Hiroko

American Heart Association Scientific Sessions 2020, Nov 13, 2020
4E-BP3 deficiency protects against autoimmune myocarditis in mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

第24回日本心不全学会学術集会, Oct 15, 2020
4E-BP3 deficiency attenuates cardiac inflammation in mice with experimental autoimmune myocarditis.

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Tsukuba Global Science Week 2020, Sep 28, 2020
The role of immune checkpoints in the development of autoimmune myocarditis in mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Tsukuba Global Science Week 2020, Sep 28, 2020

Professional Memberships

Aug, 2012 - Present

日本心臓電気生理学会
2007 - Present

THE JAPANESE CIRCULATION SOCIETY
Aug, 2005 - Present

Japan Primary Care Association

Research Projects

AMED橋渡し研究戦略的推進プログラム(シーズA)

国立研究開発法人日本医療研究開発機構, Apr, 2021 - Mar, 2022
The role of Nicotinamide phosphoribosyltransferase (Nampt) in atrial fibrillation(Fostering Joint International Research)

Fund for the Promotion of Joint International Research : Fostering Joint International Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research), Ministry of Education, Culture, Sports, Science and Technology, Japan, 2016 - 2018

DONGZHU XU
Vulnerability of Atrial Fibrillation is Increased in a Rat Model of Metabolic Syndrome Via Phosphorylation of Calcium-Calmodulin-Dependent Protein Kinase II

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2012 - 2013

XU Dong-Zhu
不整脈の発症機序解明と治療