Xu Dong-Zhu - My portal

Profile Information

Affiliation: Associate Professor, Faculty of Medicine, University of Tsukuba

J-GLOBAL ID: 201801018488258197
researchmap Member ID: 7000024551

Research Interests

AMED橋渡し研究戦略的推進プログラム(シーズA)

Research Areas

Life sciences / Cardiology /

Research History

Jul, 2018 - Present

Faculty of Medicine, University of Tsukuba
Oct, 2015 - Jun, 2018

Research fellow, Krannert Institute of Cardiology, Indiana University School of Medicine
Apr, 2011 - Dec, 2017

University of Tsukuba
1999 - 2001

医師, 内科, 中国吉林省延吉市立病院

Education

Apr, 2007 - Mar, 2011

Cardiovascular Division Institute of Clinical Medicine, Graduate School, Division of Medicine, University of Tsukuba

Awards

2006

文部科学省国費留学生, 文部科学省

許東洙

Papers

Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Aonuma, Kazuhiro, Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Okabe, Yuta, Yuan, Zixun, Li, Siqi, Murakata, Yoshiko, Tominaga, Kenichi, Nogami, Akihiko, Aonuma, Kazutaka, Ieda, Masaki, Isoda, Hiroko

Clinical science (London, England : 1979), 136(24) 1831-1849, Dec 22, 2022
ASO Visual Abstract: Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation in Patients with Cancer: A Meta-analysis

Inoue, Keiko, Tajiri, Kazuko, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Annals of surgical oncology, 30(2) 723-724, Nov 17, 2022
Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation for Patients with Cancer: A Meta-Analysis

Inoue, Keiko, Tajiri, Kazuko, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Annals of surgical oncology, 30(2) 711-721, Oct 22, 2022 Peer-reviewed
Identification of potential dilated cardiomyopathy-related targets by meta-analysis and co-expression analysis of human RNA-sequencing datasets

Yuan, Zixun, Murakoshi, Nobuyuki, Xu, Dongzhu, Tajiri, Kazuko, Okabe, Yuta, Aonuma, Kazuhiro, Murakata, Yoshiko, Li, Siqi, Song, Zonghu, Shimoda, Yuzuno, Mori, Haruka, Aonuma, Kazutaka, Ieda, Masaki

Life sciences, 306 120807-120807, Jul 13, 2022
Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation

Shimoda, Yuzuno, Murakoshi, Nobuyuki, Mori, Haruka, Xu, DongZhu, Tajiri, Kazuko, Hemmi, Yasuko, Sato, Iori, Noguchi, Michiya, Nakamura, Yukio, Hayashi, Yohei, Ieda, Masaki

Stem Cell Research, 62 102793-102793, Apr 14, 2022
Right bundle branch block and risk of cardiovascular mortality: the Ibaraki Prefectural Health Study

Nakazawa, Naomi, Ishizu, Tomoko, Sairenchi, Toshimi, Yamagishi, Kazumasa, Murakoshi, Nobuyuki, Nakagawa, Daishi, Nakatsukasa, Tomofumi, Kawamatsu, Naoto, Sato, Kimi, Yamamoto, Masayoshi, Machino-Otsuka, Tomoko, Xu, DongZhu, Irie, Fujiko, Tomizawa, Takuji, Nogami, Akihiko, Aonuma, Kazutaka, Iso, Hiroyasu, Ieda, Masaki, Kawakami, Yasushi, Ota, Hitoshi

HEART AND VESSELS, Epub, Sep, 2021 Peer-reviewed
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Duo, Feng, Okabe, Yuta, Murakata, Yoshiko, Yuan, Zixun, Li, Siqi, Aonuma, Kazuhiro, Song, Zhonghu, Shimoda, Yuzuno, Mori, Haruka, Sato, Akira, Nogami, Akihiko, Aonuma, Kazutaka, Ieda, Masaki

Clinical science (London, England : 1979), 135(20) 2409-2422, Aug 13, 2021 Peer-reviewed
Loss of nocturnal dipping pattern of skin sympathetic nerve activity during and following an extended-duration work shift in residents in training

Chen, Mu, Sun, Jian, Chen, Tai-Zhong, Xu, Dong-Zhu, Wan, Juyi, Wang, Qunshan, Li, Yi-Gang

Journal of cardiology, 78(6) 509-516, Jul 16, 2021 Peer-reviewed
Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice

Li, Siqi, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, DongZhu, Yonebayashi, Saori, Okabe, Yuta, Yuan, Zixun, Feng, Duo, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zoughu, Mori, Haruka, Huang, Honglan, Aonuma, Kazutaka, Ieda, Masaki

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3), Feb, 2021 Peer-reviewed
Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice

Ogura, Yukino, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, DongZhu, Yonebayashi, Saori, Li, Siqi, Okabe, Yuta, Feng, Duo, Shimoda, Yuzuno, Song, Zoughu, Mori, Haruka, Yuan, Zixun, Aonuma, Kazutaka, Ieda, Masaki

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(2), Jan, 2021 Peer-reviewed
MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, Dongzhu, Li, Siqi, Feng, Duo, Okabe, Yuta, Yuan, Zixun, Song, Zonghu, Aonuma, Kazuhiro, Shibuya, Akira, Aonuma, Kazutaka, Ieda, Masaki

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24(24) 14481-14490, Nov, 2020 Peer-reviewed
Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells and Its Cardioprotective Effects

Aonuma, Kazuhiro, Ferdousi, Farhana, Xu, DongZhu, Tominaga, Kenichi, Isoda, Hiroko

Frontiers in cell and developmental biology, 8, Sep, 2020 Peer-reviewed
Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway

Feng, Duo, Xu, DongZhu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Qin, Rujie, Yonebayashi, Saori, Okabe, Yuta, Li, Siqi, Yuan, Zixun, Aonuma, Kazutaka, Ieda, Masaki

International journal of molecular sciences, 21(13), Jun, 2020 Peer-reviewed
Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes

Chen, Mu, Wang, Qunshan, Sun, Jian, Zhang, Peng-Pai, Li, Wei, Zhang, Rui, Mo, Bin-Feng, Chen, Tai-Zhong, Wan, Juyi, Xu, Dong-Zhu, Aonuma, Kazutaka, Li, Yi-Gang

Journal of interventional cardiology, 2020, Apr, 2020 Peer-reviewed
Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts

Yin, Dechun, Yang, Na, Tian, Zhipeng, Wu, Adonis Z, Xu, Dongzhu, Chen, Mu, Kamp, Nicholas J, Wang, Zhuo, Shen, Changyu, Chen, Zhenhui, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Chen, Peng-Sheng, Everett, Thomas H

Heart rhythm, 17(2) 332-340, Sep, 2019 Peer-reviewed
Concomitant SK current activation and sodium current inhibition cause J wave syndrome

Chen, Mu, Dong-Zhu, Xu, Wu, Adonis Z, Guo, Shuai, Wan, Juyi, Yin, Dechun, Lin, Shien-Fong, Chen, Zhenhui, Rubart-von der Lohe, Michael, Everett, Thomas H, Qu, Zhilin, Weiss, James N, Chen, Peng-Sheng

JCI Insight, 3(22), Nov, 2018 Peer-reviewed
Phospholamban regulates nuclear Ca2+ stores and inositol 1,4,5-trisphosphate mediated nuclear Ca2+ cycling in cardiomyocytes.

Dong-Zhu ,Xu

Journal of Molecular and Cellular Cardiology, Oct, 2018 Peer-reviewed
Sex-Specific Activation of SK Current by Isoproterenol Facilitates Action Potential Triangulation and Arrhythmogenesis in Rabbit Ventricles

Chen, Mu, Yin, Dechun, Guo, Shuai, Xu, Dong-Zhu, Wang, Zhuo, Chen, Zhenhui, Rubart-von der Lohe, Michael, Lin, Shien-Fong, Everett, Thomas H, Weiss, James N, Chen, Peng-Sheng

The Journal of physiology, 596(18) 4299-4322, Jun, 2018 Peer-reviewed
Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits

Dechun Yin, Mu Chen, Na Yang, Adonis Z. Wu, Dongzhu Xu, Wei-Chung Tsai, Yuan Yuan, Zhipeng Tian, Yi-Hsin Chan, Changyu Shen, Zhenhui Chen, Shien-Fong Lin, James N. Weiss, Peng-Sheng Chen, Thomas H. Everett

Heart Rhythm, 15(5) 761-769, May 1, 2018 Peer-reviewed
New Substrate-Guided Method of Predicting Slow Conducting Isthmuses of Ventricular Tachycardia: Preliminary Analysis to the Combined Use of Voltage Limit Adjustment and Fast-Fourier Transform Analysis.

kuorki, A, Nogami, M, Igarashi, M, Masuda, K, Kurosaki, Komatsu Y, Naruse Y, T, Machino, H, Yamasaki, D, Xu, N, Murakoshi, Y, Sekiguchi, K, Aonuma

Circ Arrhythm Electrophysiol., 11(4(e)005705), Apr, 2018 Peer-reviewed

Books and Other Publications

Atrial fibrillation rat model induced by transvenous catheter pacing and PPAR-γ activator as upstream therapy for age-related atrial fibrillation

Kyo,Tosyu

Mar, 2011

Presentations

LMNA遺伝子変異に起因する拡張型心筋症患者由来iPS細胞の樹立と病態モデルの作製

下田, 柚須乃, 村越, 伸行, 森, 遥香, 小林, 和真, 田尻, 和子, 許, 東洙, 佐藤, 伊織, 辺見, 康子, 林, 洋平, 家田, 真樹

第21回日本再生医療学会総会, Mar 17, 2022
Cardiomyopathy-Related Hub Genes and Upstream Regulators by Meta-analysis of RNA-Sequencing datasets

袁, 梓勛, 村越, 伸行, 許, 東洙, 田尻, 和子, 岡部, 雄太, 李, 思琪, 馮, 鐸, 米林, 沙織, 青沼, 和宏, 宋, 宗虎, 下田, 柚須乃, 家田, 真樹

第86回日本循環器学会学術集会, Mar 13, 2022
Establishment of induced pluripotent stem cell lines derived from dilated cardiomyopathic patients with LMNA mutations and generation of pathological models

Shimoda, Yuzuno, Murakoshi, Nobuyuki, Mori, Haruka, Kobayashi, Kazuma, Tajiri, Kazuko, Xu, DongZhu, Sato, Iori, Hemmi, Yasuko, Hayashi, Yohei, Ieda, Masaki

CiRA 2022 International Symposium, Feb 16, 2022
Natural compound Isorhamnetin Inhibits Angiotensin II-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice

Aonuma, Kazuhiro, Dong-Zhu , Xu, Murakoshi, Nobuyuki, Tajiri, Kazuko, Okabe, Yuta, Yonebayashi, Saori, Yuan, Zixun, Li, Siqi, Aonuma, Kazutaka, Ieda, Masaki, Isoda, Hiroko

THE 85TH ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, Mar 26, 2021
PD-L2 Immune Checkpoint Protein Protects Against Autoimmune Myocarditis in Mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

第85回日本循環器学会学術集会, Mar 26, 2021
4E-BP3 Deficiency Attenuates Cardiac Inflammation in Mice with Experimental Autoimmune Myocarditis

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

第85回日本循環器学会学術集会, Mar 26, 2021
PD-L2 Protects Against Autoreactive CD4+ T-cell Expansion and Inflammation in Autoimmune Myocarditis in Mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Okabe, Yuta, Song, Zonghu, Shimoda, Yuzuno, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

CVMW2020, Mar 12, 2021
Isorhamnetin Reverses Angiotensin II-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice

Dong-Zhu , Xu, Aonuma, Kazuhiro, Murakoshi, Nobuyuki, Tajiri, Kazuko, Tominaga, Kenichi, Ieda, Masaki, Isoda, Hiroko

American Heart Association Scientific Sessions 2020, Nov 13, 2020
4E-BP3 deficiency protects against autoimmune myocarditis in mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

第24回日本心不全学会学術集会, Oct 15, 2020
4E-BP3 deficiency attenuates cardiac inflammation in mice with experimental autoimmune myocarditis.

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Tsukuba Global Science Week 2020, Sep 28, 2020
The role of immune checkpoints in the development of autoimmune myocarditis in mice

Li, Siqi, Tajiri, Kazuko, Yonebayashi, Saori, Yuan, Zixun, Feng, Duo, Okabe, Yuta, Inoue, Keiko, Aonuma, Kazuhiro, Shimoda, Yuzuno, Song, Zonghu, Xu, DongZhu, Murakoshi, Nobuyuki, Ieda, Masaki

Tsukuba Global Science Week 2020, Sep 28, 2020
MAIR-II deficiency ameliorates cardiac remodeling post-myocardial infarction by suppressing TLR9-mediated pro-inflammatory macrophage activation

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, DongZhu, Okabe, Yuta, Li, Siqi, Yuan, Zixun, Feng, Duo, Shibuya, Akira, Aonuma, Kazutaka, Ieda, Masaki

Tsukuba Global Science Week 2020, Sep 28, 2020
翻訳開始制御分子EIF4EBP3はマウス自己免疫性心筋炎を増悪する

Li, Siqi, 田尻, 和子, 米林沙織, Zixun, Yuan, Duo, Feng, 岡部, 雄太, 井上慶子, 青沼和宏, 下田柚子乃, Zonghu, Song, 許, 東洙, 村越, 伸行, 家田, 真樹

第3回日本腫瘍循環器学会学術集会, Sep 11, 2020
4E-BP3 deficiency ameliorates autoimmune myocarditis in mice

Siqi, Li, 田尻, 和子, 米林沙織, Zixun, Yuan, 馮鐸, 岡部雄太, 東洙, 許, 村越伸行, 家田真樹

第6回日本心筋症研究会, Aug 21, 2020
Impaired Peripheral Immune Tolerance to Cardiac Myosin Leads to Chronic Myocardial Inflammation

Tajiri, Kazuko, Imanaka-Yoshida, Kyoko, Hiroe, Michiaki, Li, Siqi, Yonebayashi, Saori, Feng, Duo, Yuan, Zixun, Okabe, Yuta, Xu, DongZhu, Murakoshi, Nobuyuki, Aonuma, Kazutaka, Ieda, Masaki

第84回日本循環器学会学術集会, Jul 27, 2020
MAIR-II deficiency improves cardiac remodeling by suppressing TLR9-mediated pro-inflammatory macrophage activation post-myocardial infarction

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, Xu, DongZhu, Okabe, Yuta, Li, Siqi, Yuan, Zixun, Feng, Duo, Shibuya, Akira, Aonuma, Kazutaka, Ieda, Masaki

第84回日本循環器学会学術集会, Jul 27, 2020
MAIR-II deficiency ameliorates adverse cardiac remodeling post-myocardial infarction

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, 東洙, 許, Shibuya, Akira, Aonuma, Kazutaka, Ieda, Masaki

CVMW2019 心血管代謝週間, Dec 13, 2019
Deletion of the nicotinamide phosphoribosyltransferase (Nampt) and high-fat diet increases atrial fibrillation inducibility through altering calcium handling pathway

Duo, Feng, 東洙, 許, Murakoshi, Nobuyuki, Tajiri, Kazuko, Yonebayashi, Saori, Aonuma, Kazutaka, Ieda, Masaki

CVMW2019 心血管代謝週間, Dec 13, 2019
MAIR-II deficiency promotes favorable cardiac remodeling post-myocardial infarction

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, 東洙, 許, Okabe, Yuta, Li, Siqi, Yuan, Zi Xun, Shibuya, Akira, Aonuma, Kazutaka, Ieda, Masaki

Tsukuba Conference 2019, Oct 2, 2019
MAIR-II deficiency prevents exacerbated cardiac inflammation and fibrosis post-myocardial infarction

Yonebayashi, Saori, Tajiri, Kazuko, Murakoshi, Nobuyuki, 東洙, 許, Okabe, Yuta, Li, Siqi, Yuan, Zi Xun, Shibuya, Akira, Aonuma, Kazutaka, Ieda, Masaki

The 3rd JCS Council Forum on Basic CardioVasculr Research, Sep 6, 2019

Professional Memberships

Research Projects

AMED橋渡し研究戦略的推進プログラム(シーズA)

国立研究開発法人日本医療研究開発機構, Apr, 2021 - Mar, 2022
The role of Nicotinamide phosphoribosyltransferase (Nampt) in atrial fibrillation(Fostering Joint International Research)

Fund for the Promotion of Joint International Research : Fostering Joint International Research, 文部科学省, 2016 - 2018

DONGZHU XU
肥満による心房細動発症機序の解明

若手研究(B), 日本学術振興会, 2012 - 2013

許東洙
不整脈の発症機序解明と治療