宮原大貴 (Hiroki MIYAHARA) - マイポータル

基本情報

所属: 信州大学先鋭領域融合研究群　バイオメディカル研究所　ニューロヘルスイノベーション助教（特定雇用）

学位: 博士（医学）(2017年信州大学)

J-GLOBAL ID: 201801014473689285
researchmap会員ID: 7000024561

研究キーワード

アミロイドーシス

経歴

2018年

信州大学医学部医学科助教（特定雇用）

学歴

論文

Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene

Mori M, Liu C, Yoshizawa T, Miyahara H, Dai J, Igarashi Y, Cui X, Li Y, Kang X, Higuchi K

Mamm Genome 33(3) 451-464 2022年
Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner

Mori M, Dai J, Miyahara H, Li Y, Kang X, Yoshimi K, Mashimo T, Higuchi K, Mathumoto K

Exp Anim 72(2) 233-241 2022年
Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis

Miyahara H, Dai J, Li Y, Cui X, Takeuchi H, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K

Amyloid 30(2) 225-238 2022年筆頭著者責任著者
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway

Cui X, Sawashita J, Dai J, Liu C, Igarashi Y, Mori M, Miyahara H, Higuchi K

Dis Model Mech 15(3) dmm049327 2022年責任著者
Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-A mice

Yuichi Igarashi, Shiho Iida, Jian Dai, Jia Huo, Xiaoran Cui, Jinko Sawashita, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi

Biomedicine & Pharmacotherapy 2021年
Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway

Jian Dai, Ying Li, Fuyuki Kametani, Xiaoran Cui, Yuichi Igarashi, Jia Huo, Hiroki Miyahara, Masayuki Mori,Keiichi Higuchi

Elife 2020年
Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors

Dai J, Ding X, Miyahara H, Xu Z, Cui X, Igarashi Y, Sawashita J, Mori M, Higuchi K

Oxid Med Cell Longev Volume 2019 1263274 2019年
Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis

Miyahara H, Sawashita J, Ishikawa E, Yang M, Ding X, Liu Y, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K

J Proteomics 172(172) 111-121 2018年2月10日
Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells

Huo J, Xu Z, Hosoe K, Kubo H, Miyahara H, Dai J, Mori M, Sawashita J, Higuchi K

Oxid Med Cell Longev 3181759 2018年
Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis

Ding X, Liu Y, Yang M, Li L, Miyahara H, Dai J, Xu Z, Matsumoto, Mori M, Higuchi k, Sawashita J

Exp Anim 67(2) 105-115 2018年
Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure

Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H, Sawashita J, Higuchi K

Sci Rep (8) 5620 2018年
Apolipoprotein A-II accelerates reactive AA amyloidosis

Yang M, Liu Y, Li L, Miyahara H, Ding X, Dai J, Sawashita J, Mori M, Higuchi K

Amyloid 24((sup1)) 147-148 2017年3月
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis

Li L, Sawashita J, Ding X, Yang M, Xu Z, Miyahara H, Mori M, Higuchi K

PLoS ONE 12(2) e0172402 2017年2月
Distribution of transmissible amyloid proteins in the liver with apolipoprotein A-II amyloidosis

Liu Y, Sawashita J, Wang Y, Li L, Miyahara H, Ding X, Yang M, Higuchi K

Shinshu Med J 64((4)) 183-194 2016年
Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart

Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding X, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y, Higuchi K

Lab Invest 95(3) 320-333 2015年3月
Factors to preserve CpG-rich sequences in methylated CpG islands

Miyahara H, Hirose O, Satou K, Yamada Y

BMC Genomics 16(16) 144 2015年2月

講演・口頭発表等

CURCUMIN PROMOTES PROGRESSION OF AApoAII AMYLOIDOSIS IN MICE BY ACTIVATING THE PPARα SIGNALING PATHWAY

Dai Jian, Cui Xiaoran, Igarashi Yuichi, Li Ying, Miyahara Hiroki, Mori Masayuki, Higuchi Keiichi

The XVII International Symposium of Amyloidosis 2020年
A cellular model of amyloid degradation using macrophages cultured with mouse AApoAII amyloid fibrils

Hiroki Miyahara, Xiaoran Cui, Yuichi Igarashi, Ying Li, Jian Dai, Masayuki Mori, Keiichi Higuchi

The XVII International Symposium of Amyloidosis 2020年
Proteomic Analysis of Mouse AApoAII Amyloidosis

Miyahara H

The 10th Institute for Biomedical Sciences International Symposium 2018年
Comprehensive proteomic analysis of Mouse AApoAII amyloidosis

Miyahara H, Mori M, Higuchi K

Asian Pacific Prion Symposium 2018 (APPS2018) 2018年
Proteomic Profiles of Mouse AApoAII Amyloid Fibrils Provide Insights into the Involvement of Lipoproteins in the Pathology of Amyloidosis

Miyahara H, Mori M, Higuchi K

第18回日本蛋白科学会年会 2018年

所属学協会

共同研究・競争的資金等の研究課題

アミロイドーシス発症機構の分子生物学的研究