MISC

国際誌
2020年4月8日

Anaphylaxis caused by butylscopolamine bromide: a case report.

JA clinical reports
  • Toshie Shiraishi
  • ,
  • Mitsuyo Nakamura
  • ,
  • Tatsuo Horiuchi
  • ,
  • Tomonori Takazawa

6
1
開始ページ
26
終了ページ
26
記述言語
英語
掲載種別
DOI
10.1186/s40981-020-00331-w

BACKGROUND: There have been only few reports on butylscopolamine-induced anaphylaxis despite its global usage as an anticholinergic agent for approximately 70 years. We present a case of anaphylaxis caused by butylscopolamine. CASE PRESENTATION: A 63-year-old woman underwent gastrointestinal endoscopic examination. She developed facial cyanosis and hypoxia after intravenous administration of butylscopolamine 10 mg, and her blood pressure was unmeasurable. Her hemodynamic condition recovered after a total of 0.6 mg adrenaline and bolus administration of 100 mg hydrocortisone. One hour after the onset of hypotension, both plasma histamine and serum tryptase were remarkably elevated to 271.7 nmol/L and 174 μg/L, respectively. Skin tests performed 47 days after anaphylaxis showed a positive result only for butylscopolamine among the exposed agents, which was confirmed by basophil activation tests using CD203c and CD63 as markers. CONCLUSION: Butylscopolamine has the potential to cause severe anaphylaxis; hence, identification of the causative agent is important to prevent recurrence of anaphylaxis.

リンク情報
DOI
https://doi.org/10.1186/s40981-020-00331-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32270308
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142184
ID情報
  • DOI : 10.1186/s40981-020-00331-w
  • PubMed ID : 32270308
  • PubMed Central 記事ID : PMC7142184

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