論文

国際誌
2021年7月7日

Vagus Nerve Stimulation with Mild Stimulation Intensity Exerts Anti-Inflammatory and Neuroprotective Effects in Parkinson's Disease Model Rats.

Biomedicines
  • Ittetsu Kin
  • Tatsuya Sasaki
  • Takao Yasuhara
  • Masahiro Kameda
  • Takashi Agari
  • Mihoko Okazaki
  • Kakeru Hosomoto
  • Yosuke Okazaki
  • Satoru Yabuno
  • Satoshi Kawauchi
  • Ken Kuwahara
  • Jun Morimoto
  • Kyohei Kin
  • Michiari Umakoshi
  • Yousuke Tomita
  • Naoki Tajiri
  • Cesario V Borlongan
  • Isao Date
  • 全て表示

9
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/biomedicines9070789

BACKGROUND: The major surgical treatment for Parkinson's disease (PD) is deep brain stimulation (DBS), but a less invasive treatment is desired. Vagus nerve stimulation (VNS) is a relatively safe treatment without cerebral invasiveness. In this study, we developed a wireless controllable electrical stimulator to examine the efficacy of VNS on PD model rats. METHODS: Adult female Sprague-Dawley rats underwent placement of a cuff-type electrode and stimulator on the vagus nerve. Following which, 6-hydroxydopamine (6-OHDA) was administered into the left striatum to prepare a PD model. VNS was started immediately after 6-OHDA administration and continued for 14 days. We evaluated the therapeutic effects of VNS with behavioral and immunohistochemical outcome assays under different stimulation intensity (0.1, 0.25, 0.5 and 1 mA). RESULTS: VNS with 0.25-0.5 mA intensity remarkably improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. On the other hand, VNS with 0.1 mA and 1 mA intensity did not display significant therapeutic efficacy. CONCLUSIONS: VNS with 0.25-0.5 mA intensity has anti-inflammatory and neuroprotective effects on PD model rats induced by 6-OHDA administration. In addition, we were able to confirm the practicality and effectiveness of the new experimental device.

リンク情報
DOI
https://doi.org/10.3390/biomedicines9070789
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34356853
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301489
ID情報
  • DOI : 10.3390/biomedicines9070789
  • PubMed ID : 34356853
  • PubMed Central 記事ID : PMC8301489

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