Kazuhiro Okubo - My portal

Profile Information

Affiliation: Hospital, Ehime University

Degree: 医学（博士）(九州大学)

Researcher number: 60737576
J-GLOBAL ID: 201801010437764518
researchmap Member ID: 7000024913

Research Interests

Research History

Oct, 2018 - Present

Hospital, Ehime University
Apr, 2017 - Sep, 2018

Kyushu University
Oct, 2016 - Mar, 2017

Faculty of Medical Sciences, Kyushu University
Apr, 2014 - Sep, 2016

Kyushu University
Apr, 2008 - Mar, 2010

Kyushu University
Apr, 2007 - Mar, 2008

小児科医師, 九州厚生年金病院
Apr, 2005 - Mar, 2007

臨床研修医, 九州厚生年金病院

Education

Apr, 2010 - Mar, 2014

Faculty of Medical Sciences, Kyushu University
Apr, 1999 - Mar, 2005

School of Medicine, Kyushu University

Awards

Nov, 2017

第27回臨床内分泌代謝Update優秀ポスター賞, 日本内分泌学会

大久保一宏
Nov, 2015

第68回九州小児科学会優秀演題賞, 九州小児科学会

大久保一宏

Papers

Vascular pathomechanism in acute encephalopathy with biphasic seizures and late reduced diffusion.

Sanefuji M, Ichimiya Y, Kaku N, Sasazuki M, Yonemoto K, Torio M, Mizuguchi S, Motomura Y, Muraoka M, Lee S …

Journal of the neurological sciences, 395 141-146, Dec, 2018 Peer-reviewed
A pediatric case with prostaglandin I₂-associated thyrotoxicosis: Case report and the literature review.

Sonoda Y, Yamamura K, Ishii K, Ohkubo K, Ihara K, Sakai Y, Ohga S

Journal of clinical research in pediatric endocrinology, Oct, 2018 Peer-reviewed
Reappraising newborn screening for cobalamin C disorder.

Tocan V, Ohkubo K, Higashi K, Toda N, Kojima-Ishii K, Nishiyama K, Ishimura M, Takada H, Sakamoto O, Sasaki F …

Pediatrics and neonatology, 59(4) 415-417, Aug, 2018 Peer-reviewed
A male case with CDKL5-associated encephalopathy manifesting transient methylmalonic acidemia

Satoshi Akamine, Yoshito Ishizaki, Yasunari Sakai, Hiroyuki Torisu, Ryoko Fukai, Noriko Miyake, Kazuhiro Ohkubo, Hiroshi Koga, Masafumi Sanefuji, Ayumi Sakata …

European Journal of Medical Genetics, 61(8) 451-454, Aug 1, 2018 Peer-reviewed
Metabolic and immunological assessment of small-for-gestational-age children during one-year treatment with growth hormone: the clinical impact of apolipoproteins.

Kanako Kojima-Ishii, Naoko Toda, Kazuhiro Okubo, Vlad Tocan, Noriko Ohyama, Mika Makimura, Terumichi Matsuo, Masayuki Ochiai, Shouichi Ohga, Kenji Ihara

Endocrine journal, 65(4) 449-459, Apr 26, 2018 Peer-reviewed
Effective shunt closure for pulmonary hypertension and liver dysfunction in congenital portosystemic venous shunt

Kiyoshi Uike, Hazumu Nagata, Yuichiro Hirata, Kenichiro Yamamura, Eiko Terashi, Toshiharu Matsuura, Eiji Morihana, Kazuhiro Ohkubo, Kanako Ishii, Yasunari Sakai …

Pediatric Pulmonology, 53(4) 505-511, Apr 1, 2018 Peer-reviewed
Comprehensive screening for monogenic diabetes in 89 Japanese children with insulin-requiring antibody-negative type 1 diabetes.

Kikumi Ushijima, Maki Fukami, Tadayuki Ayabe, Satoshi Narumi, Misako Okuno, Akie Nakamura, Toshikazu Takahashi, Kenji Ihara, Kazuhiro Ohkubo, Emiko Tachikawa …

Pediatric diabetes, 19(2) 243-250, Mar, 2018 Peer-reviewed
Sustained endocrine profiles of a girl with WAGR syndrome

Yui Takada, Yasunari Sakai, Yuki Matsushita, Kazuhiro Ohkubo, Yuhki Koga, Satoshi Akamine, Michiko Torio, Yoshito Ishizaki, Masafumi Sanefuji, Hiroyuki Torisu …

BMC MEDICAL GENETICS, 18(1) 117, Oct, 2017 Peer-reviewed
Resolution of Hydronephrosis in a Patient With Mucopolysaccharidosis Type II With Enzyme Replacement Therapy

Kei Nishiyama, Takashi Imai, Kazuhiro Ohkubo, Masafumi Sanefuji, Hidetoshi Takada

UROLOGY, 101 163-165, Mar, 2017 Peer-reviewed
Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann, Sotos, and Kabuki syndromes: A nationwide survey in Japan

Naoko Toda, Kenji Ihara, Kanako Kojima-Ishii, Masayuki Ochiai, Kazuhiro Ohkubo, Yutaka Kawamoto, Yoshinori Kohno, Sakae Kumasaka, Akihiko Kawase, Yasuhisa Ueno …

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 173(2) 360-367, Feb, 2017 Peer-reviewed
The First Nationwide Survey and Genetic Analyses of Bardet-Biedl Syndrome in Japan

Makito Hirano, Wataru Satake, Kenji Ihara, Ikuya Tsuge, Shuji Kondo, Ken Saida, Hiroyuki Betsui, Kazuhiro Okubo, Hikaru Sakamoto, Shuichi Ueno …

PLOS ONE, 10(9) e0136317, Sep, 2015 Peer-reviewed
Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells

Kazuhiro Ohkubo, Yasunari Sakai, Hirosuke Inoue, Satoshi Akamine, Yoshito Ishizaki, Yuki Matsushita, Masafumi Sanefuji, Hiroyuki Torisu, Kenji Ihara, Marco Sardiello …

SCIENTIFIC REPORTS, 5 13191, Aug, 2015 Peer-reviewed
Thyroid follicular carcinoma in a fourteen-year-old girl with Graves' disease

Kanako Kojima-Ishii, Kenji Ihara, Kazuhiro Ohkubo, Terumichi Matsuo, Naoko Toda, Hiroyuki Yamashita, Shinji Kono, Toshiro Hara

Clinical Pediatric Endocrinology, 23(2) 59-64, 2014 Peer-reviewed
Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus

Yasunari Sakai, Kazuhiro Ohkubo, Yuki Matsushita, Satoshi Akamine, Yoshito Ishizaki, Hiroyuki Torisu, Kenji Ihara, Masafumi Sanefuji, Min-Seon Kim, Ki-Up Lee …

EUROPEAN JOURNAL OF MEDICAL GENETICS, 56(9) 475-483, Sep, 2013 Peer-reviewed
Hypothyroidism and levothyroxine-responsive liver dysfunction in a patient with ring chromosome 18 syndrome.

Ohkubo K, Ihara K, Ohga S, Ishimura M, Hara T

Thyroid : official journal of the American Thyroid Association, 22(10) 1080-1083, Oct, 2012 Peer-reviewed
The signal transducer and activator of transcription 5B gene polymorphism contributes to the cholesterol metabolism in Japanese children with growth hormone deficiency

Mika Makimura, Kenji Ihara, Kanako Kojima-Ishii, Takafumi Nozaki, Kazuhiro Ohkubo, Hitoshi Kohno, Junji Kishimoto, Toshiro Hara

CLINICAL ENDOCRINOLOGY, 74(5) 611-617, May, 2011 Peer-reviewed
Nephrolithiasis as an extra-intestinal presentation of pediatric inflammatory bowel disease unclassified

Michiko Torio, Masataka Ishimura, Shouichi Ohga, Takehiko Doi, Rina Utsunomiya, Kazuhiro Ohkubo, Naohiro Suga, Katsunori Tatsugami, Takayuki Matsumoto, Hidetoshi Takada …

JOURNAL OF CROHNS & COLITIS, 4(6) 674-678, Dec, 2010 Peer-reviewed

Professional Memberships

Research Projects

脂肪萎縮性糖尿病原因遺伝子POLD1の機能解析

科学研究費若手研究（B）, 文部科学省, Apr, 2016 - Mar, 2018

大久保一宏