長田秀斗 (Osada Hideto) - マイポータル

基本情報

所属: 慶應義塾医学部眼科学教室特任助教（有期）

研究者番号: 50748770
J-GLOBAL ID: 201801012354171275
researchmap会員ID: 7000025127

研究分野

ライフサイエンス / 眼科学 /

論文

Evaluation of Anti-VEGFR2 Specific Photoimmunotherapy for Targeted Regression of Neovascularization in an AMD Model.

Hideto Osada, Takashi Nishimura, Makoto Mitsunaga, Masayuki Saruta, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara, Norimitsu Ban

Investigative ophthalmology & visual science 66(6) 70-70 2025年6月2日査読有り筆頭著者
Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa

Yoko Ozawa, Eriko Toda, Kohei Homma, Hideto Osada, Norihiro Nagai, Kazuo Tsubota, Hideyuki Okano

Cells 11(9) 1497 2022年4月29日査読有り
Violet light modulates the central nervous system to regulate memory and mood

Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban …

2021年11月4日
Neuroprotective effect of 4-phenylbutyric acid against photo-stress in the retina

Mendoza N.A.G., Homma K., Osada H., Toda E., Ban N., Nagai N., Negishi K., Tsubota K., Ozawa Y.

Antioxidants 10(7) 2021年7月
ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss

Osada H, Toda E, Homma K, Guzman N.A, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, Ozawa Y

Cell Death and Disease 12(5) 2021年5月査読有り筆頭著者
Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium

Homma K., Toda E., Osada H., Nagai N., Era T., Tsubota K., Okano H., Ozawa Y.

Redox Biology 41 2021年5月
Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

Nagai N., Kawashima H., Toda E., Homma K., Osada H., Guzman N.A., Shibata S., Uchiyama Y., Okano H., Tsubota K. …

Communications Biology 3(1) 2020年12月
Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator.

Hirohiko Kawashima, Yoko Ozawa, Eriko Toda, Kohei Homma, Hideto Osada, Toshio Narimatsu, Norihiro Nagai, Kazuo Tsubota

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34(4) 5016-5026 2020年4月査読有り
Dietary spirulina supplementation protects visual function from photostress by suppressing retinal neurodegeneration in mice

Okamoto T., Kawashima H., Osada H., Toda E., Homma K., Nagai N., Imai Y., Tsubota K., Ozawa Y.

Translational Vision Science and Technology 8(6) 2019年11月
Aquaporin 4 suppresses neural hyperactivity and synaptic fatigue and fine-tunes neurotransmission to regulate visual function in the mouse retina.

Ozawa Y, Toda E, Kawashima H, Homma K, Osada H, Nagai N, Abe Y, Yasui M, Tsubota K

Mol. Neurobiol. 56 8124-8135 2019年査読有り
Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina

Hideto Osada, Tomohiro Okamoto, Hirohiko Kawashima, Eriko Toda, Seiji Miyake, Norihiro Nagai, Saori Kobayashi, Kazuo Tsubota, Yoko Ozawa

PLOS ONE 12(6) e0178627 2017年6月査読有り筆頭著者
Neuroprotective role of retinal SIRT3 against acute photo-stress.

Norimitsu Ban, Yoko Ozawa, Hideto Osada, Jonathan B Lin, Eriko Toda, Mitsuhiro Watanabe, Kenya Yuki, Shunsuke Kubota, Rajendra S Apte, Kazuo Tsubota

NPJ aging and mechanisms of disease 3 19-19 2017年
Lutein acts via multiple antioxidant pathways in the photo-stressed retina

Mamoru Kamoshita, Eriko Toda, Hideto Osada, Toshio Narimatsu, Saori Kobayashi, Kazuo Tsubota, Yoko Ozawa

SCIENTIFIC REPORTS 6 30226 2016年7月
Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.

Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y

The Journal of biological chemistry 291(14) 7373-7385 2016年4月査読有り
The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-kappa B Axis during Retinal Inflammation

Tomohiro Okamoto, Yoko Ozawa, Mamoru Kamoshita, Hideto Osada, Eriko Toda, Toshihide Kurihara, Norihiro Nagai, Kazuo Umezawa, Kazuo Tsubota

PLOS ONE 11(1) e0146517 2016年1月
Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo.

Narimatsu T, Negishi K, Miyake S, Hirasawa M, Osada H, Kurihara T, Tsubota K, Ozawa Y†

Experimental Eye Research 132 48-51 2015年3月査読有り
Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo.

Toshio Narimatsu, Kazuno Negishi, Seiji Miyake, Manabu Hirasawa, Hideto Osada, Toshihide Kurihara, Kazuo Tsubota, Yoko Ozawa

Experimental eye research 132 48-51 2015年3月
Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21

Toshihiro Banjo, Janin Grajcarek, Daisuke Yoshino, Hideto Osada, Kota Y. Miyasaka, Yasuyuki S. Kida, Yosuke Ueki, Kazuaki Nagayama, Koichi Kawakami, Takeo Matsumoto …

NATURE COMMUNICATIONS 4 1978 2013年6月

MISC

Aerobic exercise protects retinal function in type 2 diabetic mice

Mamoru Kamoshita, Hideto Osada, Eriko Toda, Kokoro Sano, Motoko Kawashima, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 57(12) 2016年9月
AMPK activation protects photoreceptors from light-induced degeneration.

Hirohiko Kawashima, Hideto Osada, Eriko Toda, Tomohiro Okamoto, Mamoru Kamoshita, Norihiro Nagai, Kazuo Tsubota, Yoko Ozawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 57(12) 2016年9月
The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-kappa B Axis during Retinal Inflammation

Tomohiro Okamoto, Mamoru Kamoshita, Hideto Osada, Eriko Toda, Norihiro Nagai, Kazuo Tsubota, Yoko Ozawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 57(12) 2016年9月
Light-induced retinal degeneration and AMPK

Hirohiko Kawashima, Hideto Osada, Tomohiro Okamoto, Norimitsu Ban, Mamoru Kamoshita, Toshihide Kurihara, Norihiro Nagai, Kazuo Tsubota, Yoko Ozawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 56(7) 2015年6月
Neuroprotective effect of rapamycin in the retina

Tomohiro Okamoto, Mamoru Kamoshita, Hideto Osada, Eriko Toda, Toshihide Kurihara, Norihiro Nagai, Kazuo Tsubota, Yoko Ozawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 56(7) 2015年6月

共同研究・競争的資金等の研究課題

非視覚型オプシンを介したバイオレットライトによる網膜血管制御機構の解明

科学研究費助成事業基盤研究(C) 2023年4月 - 2027年3月

長田秀斗
脂質の介する代謝異常による網膜変性機構の解明

文部科学省・日本学術振興会科学研究費助成事業若手研究 2019年4月 - 2021年3月

長田秀斗
AdipoR1シグナリングの網膜視細胞保護・失明予防の効果のメカニズム

日本学術振興会科学研究費助成事業若手研究(B) 2017年4月 - 2019年3月

長田秀斗, 小沢洋子