Shimpei Iikuni

J-GLOBAL         Last updated: Jun 17, 2019 at 13:04
Shimpei Iikuni
Kyoto University

Published Papers

Iikuni S, Tanimura K, Watanabe H, Shimizu Y, Saji H, Ono M
Molecular pharmaceutics   16(4) 1489-1497   Apr 2019   [Refereed]
Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Yoichi Shimizu, Kohei Sano, Hideo Saji
Theranostics   8 2992-3006   Apr 2018   [Refereed]
© Ivyspring International Publisher. Hypoxic cells dynamically translocate during tumor growth and after radiotherapy. The most desirable direction for therapy targeting hypoxic cells is combining imaging and therapy (theranostics), which may help...
Shimpei Iikuni, Masahiro Ono, Keiichi Tanimura, Hiroyuki Watanabe, Masashi Yoshimura, Hideo Saji
RSC Advances   7 20582-20590   Jan 2017   [Refereed]
© The Royal Society of Chemistry. The development of an imaging probe targeting β-amyloid (Aβ) plaques in Alzheimer's disease labeled with technetium-99m, the most commonly used radioisotope for clinical diagnoses, has been strongly anticipated. I...
Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Masashi Yoshimura, Hatsue Ishibashi-Ueda, Masafumi Ihara, Hideo Saji
PLoS ONE   11    Sep 2016   [Refereed]
© 2016 Iikuni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Kenji Matsumura, Masashi Yoshimura, Hiroyuki Kimura, Hatsue Ishibashi-Ueda, Yoko Okamoto, Masafumi Ihara, Hideo Saji
Scientific Reports   6    May 2016   [Refereed]
© 2016, Nature Publishing Group. All rights reserved. Cerebral amyloid angiopathy (CAA), characterized by the deposition of amyloid aggregates in the walls of cerebral vasculature, is a major factor in intracerebral hemorrhage and vascular cogniti...
Kenji Matsumura, Masahiro Ono, Ayane Kitada, Hiroyuki Watanabe, Masashi Yoshimura, Shimpei Iikuni, Hiroyuki Kimura, Yoko Okamoto, Masafumi Ihara, Hideo Saji
Journal of Medicinal Chemistry   58 7241-7257   Sep 2015   [Refereed]
© 2015 American Chemical Society. In order to explore novel tau-imaging agents that can selectively detect neurofibrillary tangles in Alzheimers disease (AD) brains, we designed and synthesized a series of heterocyclic phenylethenyl and (3-pyridin...
Hiroyuki Watanabe, Masahiro Ono, Shimpei Iikuni, Hiroyuki Kimura, Yoko Okamoto, Masafumi Ihara, Hideo Saji
RSC Advances   5 1009-1015   Jan 2015   [Refereed]
© The Royal Society of Chemistry 2015. In vivo imaging of β-amyloid (Aβ) plaques by non-invasive techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) may facilitate early diagnosis and drug d...
Hiroyuki Watanabe, Masahiro Ono, Shimpei Iikuni, Masashi Yoshimura, Kenji Matsumura, Hiroyuki Kimura, Hideo Saji
Bioorganic and Medicinal Chemistry Letters   24 4834-4837   Oct 2014   [Refereed]
© 2014 Elsevier Ltd. All rights reserved. Since the imaging of β-amyloid (Aβ) plaques in the brain is believed to be a useful tool for the early diagnosis of Alzheimer's disease (AD), a number of imaging probes to detect Aβ plaques have been devel...
Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Kenji Matsumura, Masashi Yoshimura, Naoya Harada, Hiroyuki Kimura, Morio Nakayama, Hideo Saji
Molecular Pharmaceutics   11 1132-1139   Apr 2014   [Refereed]
Deposition of amyloid aggregates has been regarded as an early stage of amyloidosis progression. An imaging probe that can image amyloid aggregates enables the early diagnosis of amyloidosis and contributes to the development of new medical therap...
Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Kenji Matsumura, Masashi Yoshimura, Shimpei Iikuni, Yoko Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hideo Saji
MedChemComm   5 82-85   Jan 2014   [Refereed]
We designed and synthesized a novel series of radioiodinated 3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridine (1,3,4-PODP) derivatives for imaging β-amyloid (Aβ) plaques in Alzheimer's disease (AD) brains using single photon emission computed tomography ...


Cancer radiotheranostics targeting carbonic anhydrase-IX with radiometallic chelate based on ureidosulfonamide
Shimpei Iikuni, Hiroyuki Watanabe, Yoichi Shimizu, Hideo Saji, Masahiro Ono
The 10th China-Japan-Korea Symposium on Radiopharmaceutical Science      Nov 2018   [Refereed]
Shimpei Iikuni, Masahiro Ono
第77回日本癌学会学術総会      Sep 2018   [Refereed]
放射性金属薬剤を用いた炭酸脱水酵素-IX 高発現腫瘍に対する Radiotheranostics
Shimpei Iikuni
第18回放射性医薬品・画像診断薬研究会/第2回日本核医学会分科会 放射性薬品科学研究会      Sep 2018   [Refereed]
飯國慎平, 小野正博, 渡邊裕之, 志水陽一, 佐治英郎
日本薬学会第138年会   138th(2) ROMBUNNO.28W‐am02S-243   Mar 2018   [Refereed]
Development of radiometallic chelate as cancer radiotheranostic agent targeting carbonic anhydrase-IX
Iikuni Shimpei, Ono Masahiro
CANCER SCIENCE   109 734   Jan 2018   [Refereed]
飯國 慎平, 小野 正博, 渡邊 裕之, 佐治 英郎
第57回日本核医学会学術総会   54(Suppl.) S198-S198   Sep 2017   [Refereed]
飯國 慎平, 小野 正博
第76回日本癌学会学術総会   76回 P-2329   Sep 2017   [Refereed]
炭酸脱水酵素-IX を標的とした放射性金属薬剤によるがんの Radiotheranostics
Shimpei Iikuni
第17回放射性医薬品・画像診断薬研究会/第1回日本核医学会分科会 放射性薬品科学研究会      Sep 2017   [Refereed]
Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Hideo Saji
The 10th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists      May 2017   [Refereed]
飯國慎平, 小野正博, 渡邊裕之, 佐治英郎
日本薬学会第137年会   137th(2) ROMBUNNO.27P‐am12S-256   Mar 2017   [Refereed]
谷村圭一, 小野正博, 飯國慎平, 渡邊裕之, 佐治英郎
日本薬学会137年会   137th(2) ROMBUNNO.26PA‐pm131S-281   Mar 2017   [Refereed]
土井雄貴, 小野正博, 吉村優志, 飯國慎平, 渡邊裕之, 佐治英郎
日本薬学会136年会   136th(2) ROMBUNNO.28AB‐AM405S-275   Mar 2016   [Refereed]
飯國慎平, 小野正博, 渡邊裕之, 北田彩音, 松吉康志, 佐治英郎
日本薬学会136年会   136th ROMBUNNO.27L‐AM03S   2016   [Refereed]
飯國慎平, 小野正博, 渡邊裕之, 木村寛之, 佐治英郎
第55回日本核医学会学術総会   52(3) 298   Sep 2015   [Refereed]
牧野顕, 森哲也, 飯國慎平, 小野正博, 佐治英郎, 岡沢秀彦, 清野泰
第55回日本核医学会学術総会   52(3) 273   Sep 2015   [Refereed]
飯國慎平, 小野正博, 渡邊裕之, 木村寛之, 佐治英郎
日本薬学会135年会   135th ROMBUNNO.26W-PM19S   2015   [Refereed]
飯國慎平, 小野正博, 渡邊裕之, 木村寛之, 佐治英郎
第54回日本核医学会学術総会   51(3) 335   Sep 2014   [Refereed]
2 価 99mTc 錯体を用いた脳アミロイドアンギオパチーの生体イメージング
Shimpei Iikuni
第12回次世代を担う若手のためのフィジカル・ファーマフォーラム      Jul 2014   [Refereed]
牧野顕, 森哲也, 飯國慎平, 小野正博, 佐治英郎, 清野泰
JSMI Rep   7(2) 123   May 2014
飯國 慎平, 小野 正博, 渡邊 裕之, 木村 寛之, 佐治 英郎
日本薬学会134年会   134年会(2) 255-255   Mar 2014   [Refereed]