三浦修 (Osamu Miura) - マイポータル

基本情報

所属: 東京医科歯科大学大学院医歯学総合研究科医歯学系専攻先端医療開発学講座血液内科学教授

学位: 医学博士

J-GLOBAL ID: 201801013918035276
researchmap会員ID: 7000025244

研究分野

ライフサイエンス / 血液、腫瘍内科学 /

経歴

2016年9月 - 現在

東京医科歯科大学, 大学院医歯学総合研究科医歯学系専攻先端医療開発学講座血液内科学, 主任教授
2000年4月 - 2016年8月

東京医科歯科大学, 大学院医歯学総合研究科医歯学系専攻先端医療開発学講座血液内科学, 教授

論文

172

FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM.

Daisuke Watanabe, Ayako Nogami, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miura

Cancers (Basel) 11(12) 2019年11月査読有り
Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma.

Kouhei Yamamoto, Shinya Abe, Ayaka Honda, Jun Hashimoto, Yuuki Aizawa, Sachiko Ishibashi, Taro Takemura, Nobutaka Hanagata, Masahide Yamamoto, Osamu Miura …

Lab. Invest. 2019年9月
Soluble Interleukin-2 Receptor Level at Diagnosis Predicts Prognosis of Patients With Follicular Lymphoma Irrespective of Initial Management Strategy.

Masahide Yamamoto, Keisuke Tanaka, Yoshihiro Umezawa, Toshikage Nagao, Shigeo Toyota, Osamu Miura

Anticancer Res. 39(9) 5115-5122 2019年9月査読有り
Methotrexate-associated Classical Hodgkin Lymphoma Shows Distinct Clinicopathological Features but Comparable Clinical Outcomes With Sporadic Cases.

Kota Yoshifuji, Yoshihiro Umezawa, Ayako Ichikawa, Ken Watanabe, Osamu Miura, Masahide Yamamoto

In Vivo 33(5) 1599-1604 2019年9月査読有り
TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferation.

Emi Uchida, Shihoko Suwa, Ryoto Yoshimoto, Ken Watanabe, Takeshi Kasama, Osamu Miura, Tetsuya Fukuda

Int. J. Oncol. 2019年5月査読有り
Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress.

Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida, Keigo Okada, Ayako Nogami, Osamu Miura

Cancer Lett. 453 84-94 2019年4月査読有り
CD79B mutations in primary vitreoretinal lymphoma: Diagnostic and prognostic potential.

Ichiro Yonese, Hiroshi Takase, Mayumi Yoshimori, Erika Onozawa, Akiho Tsuzura, Tohru Miki, Manabu Mochizuki, Osamu Miura, Ayako Arai

Eur. J. Haematol. 102(2) 191-196 2019年2月査読有り
Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway.

Ayako Nogami, Keigo Okada, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miura

Transl Oncol 12(2) 336-349 2019年2月査読有り
Tumor Identification of Less Aggressive or Indolent Lymphoma With Whole-Body 11C-Acetate PET/CT.

Junichi Tsuchiya, Masahide Yamamoto, Hyeyeol Bae, Takumi Oshima, Tomohiro Yoneyama, Osamu Miura, Ukihide Tateishi

Clin Nucl Med 44(4) 276-281 2019年1月査読有り
Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma.

Makoto Nakagawa, Shuhei Fujita, Takuo Katsumoto, Kazutsune Yamagata, Yoko Ogawara, Ayuna Hattori, Yuki Kagiyama, Daisuke Honma, Kazushi Araki, Tatsuya Inoue …

Cancer Sci. 110(1) 194-208 2019年1月査読有り
STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target.

Erika Onozawa, Haruna Shibayama, Honami Takada, Ken-Ichi Imadome, Sho Aoki, Mayumi Yoshimori, Norio Shimizu, Shigeyoshi Fujiwara, Takatoshi Koyama, Osamu Miura …

Oncotarget 9(57) 31077-31089 2018年7月査読有り
Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2

Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Ayako Nogami, Gaku Oshikawa, Toshikage Nagao, Osamu Miura

Oncotarget 9(42) 26834-26851 2018年6月1日査読有り
FDG-PET/CT findings of chronic active Epstein-Barr virus infection.

Akira Toriihara, Ayako Arai, Masashi Nakadate, Kouhei Yamamoto, Ken-Ichi Imadome, Osamu Miura, Ukihide Tateishi

Leuk. Lymphoma 59(6) 1470-1473 2018年6月査読有り
Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma

Yuko Kinowaki, Morito Kurata, Sachiko Ishibashi, Masumi Ikeda, Anna Tatsuzawa, Masahide Yamamoto, Osamu Miura, Masanobu Kitagawa, Kouhei Yamamoto

Laboratory Investigation 98(5) 609-619 2018年5月1日査読有り
[Cerebrospinal fluid findings in chronic active Epstein-Barr virus infection with central nervous system involvement].

Yoshimori M, Imadome KI, Tomii S, Yamamoto K, Miura O, Arai A

[Rinsho ketsueki] The Japanese journal of clinical hematology 59(4) 367-372 2018年
[Successful readministration of L-asparaginase after development of severe hypertriglyceridemia in a young adult with T-cell acute lymphoblastic leukemia].

Watanabe K, Yoshifuji K, Ohkawa R, Tozuka M, Miura O, Arai A

[Rinsho ketsueki] The Japanese journal of clinical hematology 59(12) 2555-2560 2018年
FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa, Osamu Miura

Oncotarget 9(10) 8870-8886 2018年査読有り
Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1)

Yoshihiro Umezawa, Hiroki Akiyama, Keigo Okada, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Tetsuya Kurosu, Osamu Miura

JOURNAL OF BIOLOGICAL CHEMISTRY 292(48) 19639-19655 2017年12月査読有り
Atypical chronic myeloid leukemia with isochromosome (X)(p10): A case report

Masahide Yamamoto, Sayaka Suzuki, Jun-Ichi Mukae, Keisuke Tanaka, Ken Watanabe, Gaku Oshikawa, Tetsuya Fukuda, Naomi Murakami, Osamu Miura

ONCOLOGY LETTERS 14(3) 3717-3721 2017年9月査読有り
Acute myeloid leukemia with t(3;21)(q26.2;q22) developing following low-dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case report

Keisuke Tanaka, Gaku Oshikawa, Hiroki Akiyama, Shinya Ishida, Toshikage Nagao, Masahide Yamamoto, Osamu Miura

ONCOLOGY LETTERS 14(1) 97-102 2017年7月

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