Mitsuhiro Enomoto - My portal

Profile Information

Affiliation: Visiting Lecturer, Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery, Tokyo Medical and Dental University

Researcher number: 90451971
J-GLOBAL ID: 201801010009701862
researchmap Member ID: 7000025300

Research Areas

Life sciences / Orthopedics /

Research History

May, 2020 - Present

Visiting Lecturer, Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery, Tokyo Medical and Dental University
May, 2019 - Present

Visiting Lecturer, Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery, Tokyo Medical and Dental University
Oct, 2014 - Present

Junior Associate Professor, Sports Science Organization Clinical Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University
May, 2019 - Mar, 2020

Visiting Lecturer, Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery, Tokyo Medical and Dental University
May, 2018 - Apr, 2019

Visiting Lecturer, Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery, Tokyo Medical and Dental University
May, 2017 - Mar, 2018

Visiting Lecturer, Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery, Tokyo Medical and Dental University
Nov, 2008 - Mar, 2017

Junior Associate Professor, Medical Hospital Central Clinical Facilities Sports Medicine Center, Tokyo Medical and Dental University
Jul, 2011 - Feb, 2016

Project Junior Associate Professor, Medical Hospital Central Clinical Facilities Hyperbaric Medical Center, Tokyo Medical and Dental University
Jan, 2014 - Sep, 2014

Junior Associate Professor, Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University

Education

Committee Memberships

Nov, 2013 - Present

幹事, 日本高気圧環境・潜水医学会

Awards

Papers

Multiple and early hyperbaric oxygen treatments enhance muscle healing after muscle contusion injury: a pilot study.

Naoki Yamamoto, Takuya Oyaizu, Kazuyoshi Yagishita, Mitsuhiro Enomoto, Masaki Horie, Atsushi Okawa

Undersea Hyperb Med, 48(3) 227-238, 2021 Peer-reviewed
DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models.

Hiroyuki Yokoyama, Takashi Hirai, Tetsuya Nagata, Mitsuhiro Enomoto, Hidetoshi Kaburagi, Li Leiyo, Takayuki Motoyoshi, Toshitaka Yoshii, Atsushi Okawa, Takanori Yokota

J Pain Res, 13 3031-3043, Nov, 2020
Hyperbaric Oxygen Therapy Promotes Muscle Recovery After Contusion Injury Via Angiogenesis By Reactive Nitrogen Species

Yamamoto Naoki, Oyaizu Takuya, Yagishita Kazuyoshi, Enomoto Mitsuhiro, Horie Masaki, Ohara Toshiyuki, Shioda Mikio, Takada Ryohei, Okawa Atsushi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 52(17) 929-929, Jul, 2020
Evaluation of neural activity by magnetospinography with 3D sensors.

Kyohei Sakaki, Yuko Hoshino, Shigenori Kawabata, Yoshiaki Adachi, Taishi Watanabe, Kensuke Sekihara, Senichi Ishii, Masaki Tomori, Shoji Tomizawa, Mitsuhiro Enomoto …

Clin Neurophysiol, 131(6) 1252-1266, Jun, 2020
Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair.

Leyang Li, Hiroyuki Yokoyama, Hidetoshi Kaburagi, Takashi Hirai, Kunikazu Tsuji, Mitsuhiro Enomoto, Yoshiaki Wakabayashi, Atsushi Okawa

Neural Regen Res, 15(4) 731-738, Apr, 2020
VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration.

Naoki Yamamoto, Takuya Oyaizu, Mitsuhiro Enomoto, Masaki Horie, Masato Yuasa, Atsushi Okawa, Kazuyoshi Yagishita

Sci Rep, 10(1) 2744-2744, Feb, 2020
Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation

Takuya Oyaizu, Mitsuhiro Enomoto, Naoki Yamamoto, Kunikazu Tsuji, Masaki Horie, Takeshi Muneta, Ichiro Sekiya, Atsushi Okawa, Kazuyoshi Yagishita

Scientific Reports, 8(1) 1288-1288, Dec 1, 2018
A multi-train electrical stimulation protocol facilitates transcranial electrical motor evoked potentials and increases induction rate and reproducibility even in patients with preoperative neurological deficits

Shuta Ushio, Shigenori Kawabata, Satoshi Sumiya, Tsuyoshi Kato, Toshitaka Yoshii, Tsuyoshi Yamada, Mitsuhiro Enomoto, Atsushi Okawa

Journal of Clinical Monitoring and Computing, 32(3) 549-558, Jun 1, 2018
Anterior cervical corpectomy and fusion using a synthetic hydroxyapatite graft for ossification of the posterior longitudinal ligament

Toshitaka Yoshii, Takashi Hirai, Kenichiro Sakai, Shinichi Sotome, Mitsuhiro Enomoto, Tsuyoshi Yamada, Hiroyuki Inose, Tsuyoshi Kato, Shigenori Kawabata, Atsushi Okawa

Orthopedics, 40(2) e334-e339, Mar 1, 2017 Peer-reviewed
Elimination of CT-detected gas bubbles derived from decompression illness with abdominal symptoms after a short hyperbaric oxygen treatment in a monoplace chamber: a case report.

Takuya Oyaizu, Mitsuhiro Enomoto, Toshihide Tsujimoto, Yasushi Kojima, Atsushi Okawa, Kazuyoshi Yagishita

Undersea Hyperb Med, 44(2) 167-171, Mar, 2017
Hyperbaric oxygen therapy for a refractory skin ulcer after radical mastectomy and radiation therapy: a case report.

Mitsuhiro Enomoto, Kazuyoshi Yagishita, Kae Okuma, Takuya Oyaizu, Yasushi Kojima, Atsushi Okubo, Takuma Maeda, Satoko Miyamoto, Atsushi Okawa

J Med Case Rep, 11(1) 5-5, Jan, 2017
Shorter sleep onset latency in patients undergoing hyperbaric oxygen treatment

Akihito Uezato, Mitsuhiro Enomoto, Meiyo Tamaoka, Mizue Hobo, Shusuke Inukai, Masayuki Hideshima, Yasunari Miyazaki, Toru Nishikawa, Kazuyoshi Yagishita

Psychiatry and Clinical Neurosciences, 71(1) 73-74, Jan 1, 2017 Peer-reviewed
The Effect of Teeth Clenching on Dynamic Balance at Jump-Landing: A Pilot Study.

Tomomasa Nakamura, Yuriko Yoshida, Hiroshi Churei, Junya Aizawa, Kenji Hirohata, Takehiro Ohmi, Shunsuke Ohji, Toshiyuki Takahashi, Mitsuhiro Enomoto, Toshiaki Ueno …

J Appl Biomech, 1-19, Dec, 2016 Peer-reviewed
Anterior decompression with fusion versus posterior decompression with fusion for massive cervical ossification of the posterior longitudinal ligament with a ≥50% canal occupying ratio: a multicenter retrospective study

Toshitaka Yoshii, Kenichiro Sakai, Takashi Hirai, Tsuyoshi Yamada, Hiroyuki Inose, Tsuyoshi Kato, Mitsuhiro Enomoto, Shoji Tomizawa, Shigenori Kawabata, Yoshiyasu Arai …

Spine Journal, 16(11) 1351-1357, Nov 1, 2016 Peer-reviewed
Otological complications associated with hyperbaric oxygen therapy

Yoko Yamamoto, Yoshihiro Noguchi, Mitsuhiro Enomoto, Kazuyoshi Yagishita, Ken Kitamura

European Archives of Oto-Rhino-Laryngology, 273(9) 2487-2493, Sep 1, 2016
What is the optimal management of decompression illness?: Treatment at Medical Hospital of Tokyo Medical and Dental University

YASUSHI KOJIMA, MITSUHIRO ENOMOTO, TAKUYA OYAIZU, KAZUYOSHI YAGISHITA

The Japanese Journal of Hyperbaric and Undersea Medicine, 51(1) 14-18, Mar, 2016 Peer-reviewedInvited
The facilitatory effects of hyperbaric oxygen treatment on membrane bone wound healing in a rat calvarial defect model.

Kairi Hayashi, Toshiyuki Takahashi, Mai Ikegawa, Masaki Horie, Takuya Oyaizu, Mitsuhiro Enomoto, Shunichi Shibata, Kazuyoshi Yagishita, Toshiaki Ueno

Undersea Hyperb Med, 43(2) 135-142, 2016 Peer-reviewed
Efficient Gene Suppression in Dorsal Root Ganglia and Spinal Cord Using Adeno-Associated Virus Vectors Encoding Short-Hairpin RNA.

Mitsuhiro Enomoto, Takashi Hirai, Hidetoshi Kaburagi, Takanori Yokota

Methods Mol. Biol., 1364 277-290, 2016 Invited
The effects of delayed recompression treatment over 7 days after the onset of symptoms in patients with mild decompression illness

YASUSHI KOJIMA, MITSUHIRO ENOMOTO, TAKUYA OYAIZU, KAZUYOSHI YAGISHITA

The Japanese Journal of Hyperbaric and Undersea Medicine, 50(3) 129-134, Sep, 2015 Peer-reviewed
Bone marrow stromal cells combined with a honeycomb collagen sponge facilitate neurite elongation in vitro and neural restoration in the hemisected rat spinal cord

Madoka Onuma-Ukegawa, Kush Bhatt, Takashi Hirai, Hidetoshi Kaburagi, Shinichi Sotome, Yoshiaki Wakabayashi, Shizuko Ichinose, Kenichi Shinomiya, Atsushi Okawa, Mitsuhiro Enomoto

Cell Transplantation, 24(7) 1283-1297, Jul 15, 2015 Peer-reviewed

Misc.

【腰痛治療の革新-慢性腰痛・神経障害性疼痛に対する治療のbreakthrough】神経障害性疼痛のメカニズム探索と分子標的による新規治療戦略

平井高志, 榎本光弘, 鏑木秀俊, 横山裕之, 永田哲也, 横田隆徳, 大川淳

Journal of Spine Research, 9(6) 1022-1030, Jun, 2018
Therapeutic effects of neurotrophic factors in experimental spinal cord injury models

Mitsuhiro Enomoto

Journal of Neurorestoratology, (4) 15-22, 2016 Peer-reviewedInvited
【成人脊柱変形へのアプローチ】腰椎後彎変形患者の腰背筋評価

榎本光裕, 大川淳

臨床整形外科, 50(11) 1053-1058, Nov, 2015 Invited
spinal cord and peripheral nerve disorders

50(2) 101-105, Jun, 2015 Invited
【腰椎変性後側彎症-病態から治療まで-】脊柱後彎変形に伴う腰背筋筋活動の変化

榎本光裕, 大川淳

Orthopaedics, 28(2) 15-21, Feb, 2015 Invited
骨格筋損傷に対する高気圧酸素治療効果とその分子メカニズム

堀江正樹, 榎本光裕, 下田学, 柳下和慶

日本整形外科スポーツ医学会雑誌, 34(1) 18-22, Mar, 2014 Invited
整形トピックスハニカムコラーゲンスポンジと細胞移植を併用した損傷脊髄の再建

榎本光裕

整形外科, 64(13) 1382-1382, Dec, 2013
【脊柱変形A to Z】成人の脊柱変形変性後側彎表面筋電計を用いた腰椎後彎症患者の腰背筋活動の特徴

榎本光裕, 請川大, 加藤剛, 吉井俊貴, 川端茂徳, 大川淳

整形外科, 64(8) 887-892, Jul, 2013 Invited
【表面筋電図】表面筋電計を用いた腰椎変性疾患を有する高齢者の腰背筋活動

榎本光裕, 榊経平, 富澤將司, 新井嘉容, 川端茂徳, 加藤剛, 大川淳, 四宮謙一

臨床脳波, 52(8) 417-423, Aug, 2010 Invited
An effectiveness of a lumbar corset for patients with low back pain estimated by surface electromyography

OKAWA Atsushi

The Journal of Japanese Society of Lumber Spine Disorders, 15(1) 52-57, Oct, 2009
Vocabulary Rho family small G protein

榎本光裕

整形外科, 55(1) 66-66, Jan, 2004 Invited
脊髄再生医療の現状と展望

榎本光裕, 若林良明, 四宮謙一

日本腰痛学会雑誌, 8(1) 16-20, Oct, 2002

Books and Other Publications

Neuroprotection and Regeneration of the Spinal Cord

(Role: Contributor, Transplantation of mesenchymal stem cell transduced neurotrophic factors to improve function following spinal cord injury)

Springer, Jan, 2014
Spinal Cord Injuries: Causes, Risk Factors and Management

Mitsuhiro Enomoto, Aldric T. Hama (Role: Contributor, PAIN MANAGEMENT FOLLOWING SPINAL CORD INJURY: CLINICAL AND BASIC SCIENCE PERSPECTIVES)

Nova Science Publishers, Inc, Nov, 2012
復帰をめざすスポーツ整形外科

榎本光裕, 大川淳 (Role: Contributor, テニススイングにおける動作解析と腰部疾患の関連)

Medical View社, Mar, 2011

Presentations

骨格筋圧挫損傷急性期において高気圧高酸素環境は低酸素誘導因子の増加を介して筋新生に至る過程を促進する

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 柳下和慶, 大川淳

第35回日本整形外科学会基礎学術集会, Oct 15, 2020, 日本整形外科学会
DNAマイクロアレイを用いたマウス腰部後根神経節における神経障害性疼痛関連遺伝子の調査

横山裕之, 平井高志, 榎本光裕, 鏑木秀俊, 吉井俊貴, 永田哲也, 横田隆徳, 大川淳

第35回日本整形外科学会基礎学術集会, Oct 15, 2020, 日本整形外科学会
骨格筋圧挫損傷急性期において早期の高気圧高酸素治療は筋再生促進に有用である

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 柳下和慶, 大川淳

第93回日本整形外科学会学術総会, Jun 11, 2020, 日本整形外科学会
Hyperbaric oxygen therapy promotes muscle regeneration via angiogenesis by reactive nitrogen species in muscle contusion injury of rat.

Naoki Yamamoto, Takuya Oyaizu, Masaki Horie, Mitsuhiro Enomoto, Masato Yuasa, Ryohei Takada, Kazuyoshi Yagishita

The 4th conference of Asia-pasific Undersea and Hyperbaric Medical Society, Oct 25, 2019, Asia-pasific Undersea and Hyperbaric Medical Society
骨格筋圧挫損傷急性期において高気圧高酸素環境は筋内血管新生を促進する

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 柳下和慶

第34回日本整形外科学会基礎学術集会, Oct 17, 2019, 日本整形外科学会
骨格筋圧挫損傷後に高気圧酸素治療が筋力回復与える影響

山本尚輝, 小柳津卓哉, 榎本光裕, 大原敏之, 塩田幹夫, 柳下和慶

第68回東日本整形災害外科学会, Sep 5, 2019
骨格筋圧挫損傷急性期において早期の高気圧高酸素治療は筋再生促進に有用である

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 柳下和慶

第45回日本整形外科スポーツ医学会学術集会, Aug 30, 2019, 日本整形外科スポーツ医学会
Hyperbalic Oxygen treatment promotes muscle regeneration via angiogenesis by triggering increased RNS in acute skeletal muscle injury

Naoki Yamamoto, Takuya Oyaizu, Masaki Horie, Mitsuhiro Enomoto, Masato Yuasa, Ryohei Takada, Kazuyoshi Yagishita

52th Undersea & Hyperbaric Medical Society Annual scientific meeting 2019, Jun 27, 2019, Undersea & Hyperbaric Medical Society
当院における放射線性出血性直腸炎・膀胱炎の合併症の検討

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 柳下和慶

第19回日本高気圧環境・潜水医学会関東地方会, Jun 22, 2019, 日本高気圧環境・潜水医学会
骨格筋圧挫損傷急性期においてHBOは活性窒素種を介して筋内血管新生・筋再生を促進する

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 柳下和慶

第16回日本臨床高気圧酸素・潜水医学会第54回日本高気圧環境・潜水医学会合同学術集会2019, Jun 15, 2019
高気圧酸素治療は圧挫損傷骨格筋内のNFκBを抑制し、IL-10の分泌を促進する

小柳津卓哉, 山本尚輝, 榎本光裕, 大川淳, 柳下和慶

第53回日本高気圧環境・潜水医学会学術総会, Nov 30, 2018, 日本高気圧環境・潜水医学会
当院における放射線出血性直腸炎・膀胱炎の治療成績

山本尚輝, 小柳津卓哉, 榎本光裕, 堀江正樹, 大原敏之, 塩田幹夫, 大川淳, 柳下和慶

第53回日本高気圧環境・潜水医学会学術総会, Nov 30, 2018, 日本高気圧環境・潜水医学会
高圧・高酸素環境はラット下腿筋圧挫損傷モデルにおいて損傷筋内IL-6/STAT3系を活性化させる

小柳津卓哉, 山本尚輝, 榎本光裕, 大川淳, 柳下和慶

第33回日本整形外科学会基礎学術集会, Oct 11, 2018, 日本整形外科学会
DNAマイクロアレイを用いた神経障害性疼痛関連分子の調査

横山裕之, 平井高志, 榎本光裕, 永田哲也, 横田隆徳, 大川淳

第33回日本整形外科学会基礎学術集会, Oct 11, 2018, 日本整形外科学会
マウス腓骨神経損傷慢性期での神経再建後の再生様式と機能回復再建方法による違い

李楽陽, 榎本光裕, 横山裕之, 鏑木秀俊, 平井高志, 若林良明, 大川淳

第33回日本整形外科学会基礎学術集会, Oct 11, 2018, 日本整形外科学会
遅発性放射線障害を有する患者の臨床的特徴と高気圧酸素治療に伴う合併症

榎本光裕, 前田卓馬, 小栁津卓哉, 大久保淳, 宮本聡子, 山本素希, 後藤啓吾, 小島泰史, 大川淳, 柳下和慶

第51回日本高気圧環境・潜水医学会学術総会, Dec 4, 2016, 日本高気圧環境・潜水医学会学
Role of voltage-gated sodium channels and calcium channel subunit alpha-2/delta-1 in the lumbar dorsal root ganglions of persistent peripheral neuropathic pain model mice.

Hidetoshi Kaburagi, Takashi Hirai, Takanori Yokota, Atsushi Okawa, Mitsuhiro Enomoto

Neuroscience2016, Nov 15, 2016
大規模調査からみえる女性アスリート、指導者の現状とAMED研究班の今年度の取り組み下肢疲労骨折のリスクファクター・バイオメカニクス因子の検索

柳下和慶, 相澤純也, 大見武弘, 中村香織, 廣幡健二, 大路駿介, 榎本光裕

第27回日本臨床スポーツ医学会学術集会, Nov 5, 2016
当院における膝内側側副靱帯損傷に対する高気圧酸素治療(HBO)の効果

榎本光裕, 柳下和慶, 小柳津卓哉, 相澤純也, 大路駿介, 加地真也, 中村智祐, 廣幡健二, 大見武弘, 宗田大

第27回日本臨床スポーツ医学会学術集会, Nov 5, 2016, 日本臨床スポーツ医学会
神経障害性疼痛モデルにおける腰部後根神経節での電位依存性ナトリウムおよびカルシウムチャネルα2δサブユニットの役割

鷲見晶, 鏑木秀俊, 平井高志, 大川淳, 榎本光裕

第31回日本整形外科学会基礎学術集会, Oct 13, 2016, 日本整形外科学会

Teaching Experience

修士課程・医歯学総合概論・整形外科学 (東京医科歯科大学)

Research Projects

生体骨を模した新しい複層型人工骨の開発とdrug delivery

基盤研究(C), 文部科学省/日本学術振興会, 2016 - 2018

吉井俊貴, 早乙女進一, 大川淳, 吉井俊貴, 榎本光裕
末梢神経損傷に応答する疼痛慢性化分子の探索と治療開発

基盤研究(C), 文部科学省/日本学術振興会, 2016 - 2018

榎本光裕, 辻邦和, 早乙女進一, 大川淳, 榎本光裕
高圧・高酸素による軟部組織外傷の治癒促進と作用機序の解明

基盤研究(C), 文部科学省/日本学術振興会, 2015 - 2017

柳下和慶, 柳下和慶, 加藤剛, 榎本光裕
神経筋接合部を標的にした末梢神経再生

基盤研究(C), 文部科学省/日本学術振興会, 2014 - 2016

若林良明, 若林良明, 早乙女進一, 大川淳, 榎本光裕
骨格筋損傷に対する高気圧酸素治療の作用機序の解明

基盤研究(C), 文部科学省/日本学術振興会, 2012 - 2014

柳下和慶, 柳下和慶, 加藤剛, 榎本光裕
慢性期損傷脊髄への細胞移植治療の確立とリハビリテーションの併用効果

基盤研究(C), 文部科学省/日本学術振興会, 2012 - 2014

榎本光裕, 若林良明, 早乙女進一, 大川淳, 榎本光裕
難治性疼痛
spine surgery
神経障害性疼痛における後根神経節での非神経細胞の役割と治療開発

基盤研究(C), 文部科学省/日本学術振興会

榎本光裕, 辻邦和, 大川淳, 平井高志, 榎本光裕
hyperbaric medicine
神経再生