論文

2017年1月

Hyperbaric oxygen therapy for a refractory skin ulcer after radical mastectomy and radiation therapy: a case report.

J Med Case Rep
  • Mitsuhiro Enomoto
  • ,
  • Kazuyoshi Yagishita
  • ,
  • Kae Okuma
  • ,
  • Takuya Oyaizu
  • ,
  • Yasushi Kojima
  • ,
  • Atsushi Okubo
  • ,
  • Takuma Maeda
  • ,
  • Satoko Miyamoto
  • ,
  • Atsushi Okawa

11
1
開始ページ
5
終了ページ
5
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s13256-016-1168-0

Radiation therapy is performed as an adjuvant therapy when indicated following surgical resection of malignant tumors. However, radiation exposure induces acute or chronic dermatitis, depending on the radiation dose, interval, tissue volume, or irradiated area of the body. Radiation-induced skin ulcers and osteomyelitis of the underlying bone are intractable late-stage complications of radiation therapy, and often require reconstructive surgery to cover exposed tissue. Hyperbaric oxygen therapy has been suggested as a treatment for delayed radiation injury with soft tissue and bony necrosis.<br />
A 74-year-old Japanese female underwent left radical mastectomy for breast cancer (T3N3M0, stage IIIB) in 1987. Radiation therapy was initiated 6 weeks after the surgery. She received telecobalt-60 in a total dose of 50 Gy with 25 fractions to the left supraclavicular, parasternal and left axillary regions, and electron treatment (9 MeV) in a total dose of 50 Gy in 25 fractions to the left chest wall. After irradiation, her skin became thinner and more fragile on the left chest wall, but no severe infections were observed. She noticed a small ulcer that repeatedly healed and recurred in 2000. S

リンク情報
DOI
https://doi.org/10.1186/s13256-016-1168-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28049509