論文

査読有り
2016年

The facilitatory effects of hyperbaric oxygen treatment on membrane bone wound healing in a rat calvarial defect model.

Undersea Hyperb Med
  • Kairi Hayashi
  • ,
  • Toshiyuki Takahashi
  • ,
  • Mai Ikegawa
  • ,
  • Masaki Horie
  • ,
  • Takuya Oyaizu
  • ,
  • Mitsuhiro Enomoto
  • ,
  • Shunichi Shibata
  • ,
  • Kazuyoshi Yagishita
  • ,
  • Toshiaki Ueno

43
2
開始ページ
135
終了ページ
142
記述言語
英語
掲載種別
研究論文(学術雑誌)

We examined the effect of hyperbaric oxygen (HBO2) treatment on bone wound healing in a rat calvarial defect. Critical-sized defects were created in the calvaria of adult Wistar rats. The animals were divided into four groups--HBO2, normobaric oxygen, hyperbaric air, and no treatment. Treatments were performed five days a week, for two weeks. Micro-computerized tomography and histological analysis were used to evaluate the bone defects. Regenerated bone areas were calculated as the percentage of new bone in the cross-sectional area of defect. The new bone cross-sectional area was significantly greater in the HBO2 group than in the other groups. There were no significant differences in the numbers of nucleated cells in the new bone areas. Although new bone volume per defect volume was significantly greater in the HBO2 group than in the other groups, no significant differences in bone mineral density in the new bone area were observed. These findings indicate the facilitatory role of HBO2 treatment on bone wound healing in the rat calvarial bone defect, and it does not appear to have any negative effects on bone maturity. We propose that HBO2 treatment would be useful in promoting bo

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27265990
ID情報
  • ISSN : 1066-2936
  • PubMed ID : 27265990

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