OSAKA Mizuko

J-GLOBAL         Last updated: May 21, 2019 at 02:44
 
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Name
OSAKA Mizuko
E-mail
mizu.vasctmd.ac.jp
Affiliation
Tokyo Medical and Dental University
Section
Institute of Research Research Facility Cluster Life Science and Bioethics Research Center
Job title
Assistant Professor
Degree
PhD(Tokyo Medical and Dental University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2011
 - 
Today
Assistant Professor, Graduate School of Medical and Dental Sciences Medical and Dental Sciences Public Health Life Sciences and Bioethics, Tokyo Medical and Dental University
 
Apr 2010
 - 
Mar 2011
Project Assistant Professor, Joint Institutes for Education and Research Life Science and Bioethics Research Center Department of Life Sciences and Medical Ethics, Tokyo Medical and Dental University
 
Oct 2014
 - 
Mar 2017
Assistant Professor, Research and Industry-University Alliance Organization Life Science and Bioethics Research Center, Tokyo Medical and Dental University
 
May 2017
 - 
Today
Assistant Professor, Institute of Research Research Facility Cluster Life Science and Bioethics Research Center, Tokyo Medical and Dental University
 
Apr 2017
 - 
Apr 2017
Assistant Professor, Institute of Research Research Facility Cluster Life Science and Bioethics Research Center, Tokyo Medical and Dental University
 

Education

 
Apr 1989
 - 
Mar 1994
biological science and technology, Faculty of Engineering Science, Tokyo University of Science
 

Published Papers

 
Mizuko Osaka, Shunsuke Ito, Masaki Honda, Yukihiro Inomata, Kensuke Egashira, Masayuki Yoshida
Scientific Reports   6 21391-21391   Feb 2016   [Refereed]
Exceed and chronic high-fat diet (HFD) contributes to the diagnosis and development of atherosclerosis, obesity, and metabolic syndrome. However, the key molecular component(s) triggered by HFD responsible for initiating vascular inflammation rema...
Tani M, Kamata Y, Deushi M, Osaka M, Yoshida M.
PLoS One   13(7) e0200499   Jun 2018   [Refereed]
Miyachi Y, Tsuchiya K, Komiya C, Shiba K, Shimazu N, Yamaguchi S, Deushi M, Osaka M, Inoue K, Sato Y, Matsumoto S, Kikuta J, Wake K, Yoshida M, Ishii M, Ogawa Y.
Cell Reports   18(11) 2766-2779   May 2017   [Refereed]
Michiyo Deushi, Mizuko Osaka, Kaku Nakano, Kyoichi Osada, Kensuke Egashira, Masayuki Yoshida
FEBS Open Bio   6(10) 1008-1015   Oct 2016   [Refereed]
Oxidized cholesterol (oxysterols) plays an important and multifaceted role in lipid metabolism. Here we examined whether dietary oxysterols accelerate hepatic lipid accumulation and inflammation in nonhuman primates. We also examined the effect of...
Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation.
Ito S, Osaka M, Edamatsu T, Itoh Y, Yoshida M.
Journal of Atherosclerosis Thrombosis      Feb 2016   [Refereed]

Conference Activities & Talks

 
Neutrophil extracellular traps (NETs) triggers atherosclerotic lesion development in high fat diet fed mice.
Osaka M, Deushi M, Yoshida M
The 20th International Vascular Biology Meeting 2018   3 Jun 2018   
[Background] An excess of fatty diet and hyperlipidemia contribute to atherosclerosis via a vascular inflammation. We reported that high-fat diet (HFD) induce vascular inflammation in wild-type mice and LDL receptor-deficient (LDLR-/-) mice which ...
High fat diet-triggered neutrophil activation initiates leukocyte adhesion to murine artery in vivo.
Osaka M, Yoshida M
23rd Annual Scientific meeting of ISCP 2018   26 May 2018   International Society of Cardiovascular Pharmacotherapy (ISCP)
[Background] Though high fat diet is suggested as a risk factor for atherosclerosis and cardiovascular diseases, its effect on vascular inflammation is not completely understood. Therefore, we put a high-fat diet (HFD) on wild-type mice and carefu...
Citrullinated neutrophil plays a key role in high fat diet-induced atherosclerotic plaque formation in LDL receptor null mice
Osaka M, Deushi M, Yoshida M
1st JCS Council Forum on Basic CardioVascular Research   6 Jan 2018   
[Background] Exceed fat intake has been shown to trigger the development of atherosclerosis. Previously, we reported a dominant role of neutrophil activation in high-fat diet (HFD)-induced vascular inflammation (Osaka et al. Sci Rep 2016). In this...
Neutrophil plays an important role on the development of atherosclerosis.
Mizuko Osaka, Michiyo Deushi, Hiromi Tsuru, Masayuki Yoshida
49th Annual Scientific Meeting of the Japan Atherosclerosis Society   6 Jul 2017   Japan Atherosclerosis Society
Neutrophil plays an important role on the formation of atherosclerotic lesion.
Mizuko Osaka, Michiyo Deushi, Hiromi Tsuru, Masayuki Yoshida
17 Jun 2017   Japan Section for International Society of Cardiovascular Pharmacotherapy