論文

査読有り
2017年8月

Reduced Mastication Impairs Memory Function

JOURNAL OF DENTAL RESEARCH
  • Y. Fukushima-Nakayama
  • ,
  • Takehito Ono
  • ,
  • M. Hayashi
  • ,
  • M. Inoue
  • ,
  • H. Wake
  • ,
  • Takashi Ono
  • ,
  • T. Nakashima

96
9
開始ページ
1058
終了ページ
1066
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0022034517708771
出版者・発行元
SAGE PUBLICATIONS INC

Mastication is an indispensable oral function related to physical, mental, and social health throughout life. The elderly tend to have a masticatory dysfunction due to tooth loss and fragility in the masticatory muscles with aging, potentially resulting in impaired cognitive function. Masticatory stimulation has influence on the development of the central nervous system (CNS) as well as the growth of maxillofacial tissue in children. Although the relationship between mastication and cognitive function is potentially important in the growth period, the cellular and molecular mechanisms have not been sufficiently elucidated. Here, we show that the reduced mastication resulted in impaired spatial memory and learning function owing to the morphological change and decreased activity in the hippocampus. We used an in vivo model for reduced masticatory stimuli, in which juvenile mice were fed with powder diet and found that masticatory stimulation during the growth period positively regulated long-term spatial memory to promote cognitive function. The functional linkage between mastication and brain was validated by the decrease in neurons, neurogenesis, neuronal activity, and brain-derived neurotrophic factor (BDNF) expression in the hippocampus. These findings taken together provide in vivo evidence for a functional linkage between mastication and cognitive function in the growth period, suggesting a need for novel therapeutic strategies in masticatory function-related cognitive dysfunction.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1177/0022034517708771
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28621563
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406054800013&DestApp=WOS_CPL

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