2018年3月7日
Dram1 regulates DNA damage-induced alternative autophagy.
Cell stress
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 2
- 号
- 3
- 開始ページ
- 55
- 終了ページ
- 65
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.15698/cst2018.03.127
Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 was sufficient to induce alternative autophagy. In the mechanism of alternative autophagy, Dram1 functions in the closure of isolation membranes downstream of p53. These findings indicate that Dram1 plays a pivotal role in genotoxic stress-induced alternative autophagy.
- リンク情報
- ID情報
-
- DOI : 10.15698/cst2018.03.127
- ISSN : 2523-0204
- PubMed ID : 31225467
- PubMed Central 記事ID : PMC6558930