Takahiro Mochizuki

Profile Information

Affiliation: College of Science and Engineering Department of Chemistry and Biological Science, Aoyama Gakuin University

Degree: 博士（理学）(青山学院大学)

Researcher number: 40783387
J-GLOBAL ID: 201801014966187564
researchmap Member ID: 7000026993

Research Interests

Research Areas

Research History

Apr, 2022 - Present

博士研究員, 青山学院大学理工学部化学・生命科学科
Sep, 2020 - Mar, 2022

Tohoku Medical and Pharmaceutical University
Apr, 2017 - Aug, 2020

Aoyama Gakuin University Assistant Professor
Apr, 2016 - Mar, 2017

College of Science and Engineering College of Science and Engineering Department of Chemistry and Biological Science Research Associate

Education

Apr, 2013 - Mar, 2016

Aoyama Gakuin University
Apr, 2011 - Mar, 2013

Department of Science and Engineering, Graduate School of Science and Engineering, Aoyama Gakuin University
Apr, 2007 - Mar, 2011

Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University

Papers

Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance.

Satoshi Uemura, Takahiro Mochizuki, Yusuke Kato, Tetsuo Mioka, Riseko Watanabe, Mai Fuchita, Mao Yamada, Yoichi Noda, Takashi Moriguchi, Fumiyoshi Abe

Journal of biochemistry, Apr 15, 2024
Activation of CWI pathway through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae.

Takahiro Mochizuki, Toshiki Tanigawa, Seiya Shindo, Momoka Suematsu, Yuki Oguchi, Tetsuo Mioka, Yusuke Kato, Mina Fujiyama, Eri Hatano, Masashi Yamaguchi …

Molecular biology of the cell, mbcE23030086, Jun 28, 2023
Substrate-induced differential degradation and partitioning of the two tryptophan permeases Tat1 and Tat2 into eisosomes in Saccharomyces cerevisiae.

Ryoga Ishii, Ayu Fukui, Yuri Sakihama, Shoko Kitsukawa, Ayami Futami, Takahiro Mochizuki, Makoto Nagano, Jiro Toshima, Fumiyoshi Abe

Biochimica et biophysica acta. Biomembranes, 1864(4) 183858-183858, Jan 11, 2022
Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.

N Dobriyal, P Sagarika, A Shrivastava, A K Verma, Z Islam, P Gupta, T Mochizuki, F Abe, C Sahi

Biochimica et biophysica acta. Biomembranes, 1862(11) 183435-183435, Nov 1, 2020 Peer-reviewed
Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure.

Satoshi Uemura, Takahiro Mochizuki, Kengo Amemiya, Goyu Kurosaka, Miho Yazawa, Keiko Nakamoto, Yu Ishikawa, Shingo Izawa, Fumiyoshi Abe

Journal of cell science, 133(17), Sep 9, 2020 Peer-reviewed
A novel ER membrane protein Ehg1/May24 plays a critical role in maintaining multiple nutrient permeases in yeast under high-pressure perturbation.

Goyu Kurosaka, Satoshi Uemura, Takahiro Mochizuki, Yuri Kozaki, Akiko Hozumi, Sayuri Suwa, Ryoga Ishii, Yusuke Kato, Saki Imura, Natsuho Ishida …

Scientific reports, 9(1) 18341-18341, Dec 4, 2019 Peer-reviewed
Hyperactive mutation occurs adjacent to the essential glutamate 286 for transport in the yeast tryptophan permease Tat2.

Kaori Amano, Ryoga Ishii, Takahiro Mochizuki, Shiori Takatsu, Fumiyoshi Abe

Biochemical and biophysical research communications, 509(4) 1047-1052, Feb 19, 2019 Peer-reviewed
Identification of a regulatory element for yeast tryptophan permease Tat2 ubiquitination using high hydrostatic pressure.

Ishii R, Aramaki M, Mochizuki T, Abe F

HIGH PRESSURE RESEARCH, 39(2) 258-266, Jan, 2019 Peer-reviewed
Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae.

Satoshi Uemura, Takahiro Mochizuki, Goyu Kurosaka, Takanori Hashimoto, Yuki Masukawa, Fumiyoshi Abe

Biochimica et biophysica acta. Biomembranes, 1859(10) 2076-2085, Oct, 2017 Peer-reviewed
Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae.

Takahiro Mochizuki, Yukio Kimata, Satoshi Uemura, Fumiyoshi Abe

FEMS yeast research, 15(5) fov044, Aug, 2015 Peer-reviewed
Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae.

Satoshi Uemura, Fumi Shishido, Motohiro Tani, Takahiro Mochizuki, Fumiyoshi Abe, Jin-Ichi Inokuchi

Journal of lipid research, 55(7) 1343-56, Jul, 2014 Peer-reviewed
Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2.

Yuki Usami, Satsohi Uemura, Takahiro Mochizuki, Asami Morita, Fumi Shishido, Jin-ichi Inokuchi, Fumiyoshi Abe

Biochimica et biophysica acta, 1838(7) 1719-29, Jul, 2014 Peer-reviewed
High-pressure induced degradation of the yeast tryptophan permease Tat1: quality control of membrane proteins

Abe, F, Mochizuki, T, Suzuki, A, Uemura, S

Proceedings of the 18 th Symposium for Japanese Research Group of High pressure Bioscience and Biotechnology, 122-128, 2014 Peer-reviewed
Pressure-induced endocytic degradation of the Saccharomyces cerevisiae low-affinity tryptophan permease Tat1 is mediated by Rsp5 ubiquitin ligase and functionally redundant PPxY motif proteins.

Asaha Suzuki, Takahiro Mochizuki, Satoshi Uemura, Toshiki Hiraki, Fumiyoshi Abe

Eukaryotic cell, 12(7) 990-7, Jul, 2013 Peer-reviewed

Misc.

出芽酵母の新規小胞体タンパク質Ehg1は高水圧下でアミノ酸輸送体を制御する

加藤祐介, 黒坂豪祐, 望月貴博, 伊村咲希, 石田夏穂, 石井凌賀, 上村聡志, 阿部文快

日本農芸化学会大会講演要旨集(Web), 2019, 2019
出芽酵母の静水圧ストレス耐性に関連する機能未知遺伝子EHG2/MTC6の機能解析

上村聡志, 望月貴博, 渡辺理世子, 淵田真衣, 山田真緒, 野田陽一, 阿部文快

日本生化学会大会(Web), 92nd, 2019
出芽酵母の静水圧ストレス適応におけるEGO複合体-TOR複合体1シグナル経路の意義

上村聡志, 雨宮賢吾, 望月貴博, 阿部文快

日本生化学会大会(Web), 91st, 2018
Rsp5-Bul1複合体を介した酵母トリプトファン輸送体Tat2の分解

石井凌賀, 天野香織, 荒牧真理, 野際佳奈, 上村聡志, 望月貴博, 阿部文快

日本農芸化学会大会講演要旨集(Web), 2017, 2017
出芽酵母を用いたヒト-芳香族アミノ酸輸送体(hMCT10/SLC16A10)の機能評価系の構築

上村聡志, 望月貴博, 阿部文快

日本生化学会大会(Web), 89th, 2016
高温・高圧ストレス下における酵母トリプトファン輸送体Tat1の安定性に関する解析

望月貴博, 持田和範, 上村聡志, 阿部文快, 阿部文快

日本農芸化学会大会講演要旨集(Web), 2014, 2014
出芽酵母のロイシン輸送体Bap2における機能部位の同定

宇佐美佑紀, 望月貴博, 上村聡志, 阿部文快

日本農芸化学会大会講演要旨集(Web), 2014, 2014
高圧力による酵母トリプトファン輸送体Tat1の分解促進

望月貴博, 鈴木麻葉, 上村聡志, 阿部文快

高圧討論会講演要旨集, 55th, 2014
出芽酵母の低親和性トリプトファン輸送体Tat1のユビキチン化による制御

望月貴博, 鈴木麻葉, 上村聡志, 阿部文快, 阿部文快

日本農芸化学会大会講演要旨集(Web), 2013, 2013

Books and Other Publications

高圧による酵母トリプトファン輸送体Tat1の分解と膜タンパク質の品質管理

阿部文快, 望月貴博, 鈴木麻葉, 上村聡志

高圧バイオサイエンスとバイオテクノロジー, 2015

Presentations

出芽酵母の圧力適応に重要なシグナル伝達経路の探索

酵母遺伝学フォーラム第52回研究報告会, Sep, 2019
出芽酵母の圧力適応に重要な細胞内シグナル伝達経路の探索

日本農芸化学会2019年度大会, Mar, 2019
Phosphorylation of the yeast tryptophan permease Tat1 mediates its ubiquitin-dependent degradation in response to high pressure.

10th International Conference on High Pressure Bioscience and Biotechnology, Sep, 2018
Exploration of high-pressure sensor proteins in the yeast saccharomyces cerevisiae

10th International Conference on High Pressure Bioscience and Biotechnology, Sep, 2018
出芽酵母における圧力適応機構の解明

日本農芸化学会2018年度大会, Mar, 2018
出芽酵母に圧力センサーはあるのか？

酵母遺伝学フォーラム第50回研究報告会, Sep, 2017
酵母トリプトファン輸送体Tat1の分解における細胞質末端リン酸化の関与

日本農芸化学会2017年度大会, Mar, 2017
小胞体に蓄積したTat2-Gap1キメラタンパク質は小胞体ストレス応答を引き起こす

酵母遺伝学フォーラム第48回研究報告会, Sep, 2015

Professional Memberships

酵母遺伝学フォーラム

Research Projects

細胞の圧力適応機構の解明〜酵母を用いたアプローチ〜

アーリーイーグル研究支援制度「新領域創成型若手研究」, アーリーイーグル研究助成制度, 青山学院大学, Jul, 2018 - Mar, 2019

望月貴博
A new regulatory mechanism of the yeast amino acid permease by phosphorylation

Oct, 2016 - Mar, 2018

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

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