2019年4月
Thioureas as Highly Active Catalysts for Biomimetic Bromocyclization of Geranyl Derivatives
ORGANIC LETTERS
- ,
- ,
- ,
- 巻
- 21
- 号
- 7
- 開始ページ
- 2073
- 終了ページ
- 2076
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.9b00352
- 出版者・発行元
- AMER CHEMICAL SOC
Thioureas bearing electron-deficient aryl groups show high catalytic activity in the biomimetic bromocyclization of geranyl derivatives. The reaction of geranyl derivatives with N-bromosuccinimide (NBS) proceeds rapidly in CH2Cl2 to give the corresponding bromocyclization products in high yields as a ca. 1:1 mixture of endo- and exo-isomers. The reactivity of geranyl derivatives highly depends on the terminal substituent: electron-donating substituents increase the reactivity, while electron-withdrawing substituents decrease the reactivity.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.orglett.9b00352
- ISSN : 1523-7060
- eISSN : 1523-7052
- Web of Science ID : WOS:000464247500029