論文

国際誌
2013年1月4日

Central and peripheral des-acyl ghrelin regulates body temperature in rats.

Biochemical and biophysical research communications
  • Yoshiyuki Inoue
  • ,
  • Keiko Nakahara
  • ,
  • Keisuke Maruyama
  • ,
  • Yoshiharu Suzuki
  • ,
  • Yujiro Hayashi
  • ,
  • Kenji Kangawa
  • ,
  • Noboru Murakami

430
1
開始ページ
278
終了ページ
83
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2012.10.137

In the present study using rats, we demonstrated that central and peripheral administration of des-acyl ghrelin induced a decrease in the surface temperature of the back, and an increase in the surface temperature of the tail, although the effect of peripheral administration was less marked than that of central administration. Furthermore, these effects of centrally administered des-acyl ghrelin could not be prevented by pretreatment with [D-Lys3]-GHRP-6 GH secretagogue receptor 1a (GHS-R1a) antagonists. Moreover, these actions of des-acyl ghrelin on body temperature were inhibited by the parasympathetic nerve blocker methylscopolamine but not by the sympathetic nerve blocker timolol. Using immunohistochemistry, we confirmed that des-acyl ghrelin induced an increase of cFos expression in the median preoptic nucleus (MnPO). Additionally, we found that des-acyl ghrelin dilated the aorta and tail artery in vitro. These results indicate that centrally administered des-acyl ghrelin regulates body temperature via the parasympathetic nervous system by activating neurons in the MnPO through interactions with a specific receptor distinct from the GHS-R1a, and that peripherally administered des-acyl ghrelin acts on the central nervous system by passing through the blood-brain barrier, whereas it exerts a direct action on the peripheral vascular system.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2012.10.137
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23159626
ID情報
  • DOI : 10.1016/j.bbrc.2012.10.137
  • PubMed ID : 23159626

エクスポート
BibTeX RIS