論文

国際誌
2017年12月28日

Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1.

World journal of hepatology
  • Yoshinori Ozono
  • Kenji Nagata
  • Satoru Hasuike
  • Hisayoshi Iwakiri
  • Kenichi Nakamura
  • Mai Tsuchimochi
  • Yuri Yamada
  • Yuka Takaishi
  • Mitsue Sueta
  • Tadashi Miike
  • Yoshihiro Tahara
  • Shojiro Yamamoto
  • Kotaro Shide
  • Tomonori Hidaka
  • Yoko Kubuki
  • Kazunori Kusumoto
  • Toshimasa Ochiai
  • Junya Kato
  • Naoto Komada
  • Shuichi Hirono
  • Kazuo Kuroki
  • Masafumi Shigehira
  • Kazuya Shimoda
  • 全て表示

9
36
開始ページ
1340
終了ページ
1345
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.4254/wjh.v9.i36.1340

AIM: To evaluate the efficacy and safety of a regimen containing sofosbuvir (SOF) and ledipasvir (LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype 1. METHODS: This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects (AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger (aged < 75 years) and elderly (aged ≥ 75 years). Virological data and AEs were analyzed by age group. RESULTS: The sustained virological response (SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION: Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

リンク情報
DOI
https://doi.org/10.4254/wjh.v9.i36.1340
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29359017
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756723
ID情報
  • DOI : 10.4254/wjh.v9.i36.1340
  • PubMed ID : 29359017
  • PubMed Central 記事ID : PMC5756723

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