Kazumi Kawata

Profile Information

Affiliation: Assistant Professor, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Degree: 博士(歯学）(Mar, 2007, 岡山大学)

J-GLOBAL ID: 201801014467093133
researchmap Member ID: 7000028155

Research Interests

細胞生物学

Research Areas

Life sciences / Oral medicine /

Research History

Apr, 2015 - Present

助教, 岡山大学医歯薬学総合研究科
Apr, 2012 - Mar, 2015

Department of Research Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Apr, 2010 - Mar, 2012

博士研究員, 岡山大学医歯薬学総合研究科
Jun, 2009 - Mar, 2010

助教, 岡山大学医歯薬学総合研究科

Awards

Nov, 2016

優秀ディスカッション賞, Skeletal Science Retreat 2016
May, 2013

優秀演題賞, 日本骨代謝学会

河田かずみ
May, 2013

ANZBMS 2013 Travel Award, 日本骨代謝学会
Nov, 2011

奨励論文賞, 岡山歯学会

河田かずみ
Aug, 2011

若手国際学術奨励賞, 日本CCNファミリー研究会

河田かずみ
Jun, 2011

優秀演題賞, 日本結合組織学会

河田かずみ

Papers

Expression and function of CCN2-derived circRNAs in chondrocytes

Soma Kato, Kazumi Kawata, Takashi Nishida, Tomomi Mizukawa, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of Cell Communication and Signaling, Sep 11, 2023
Do not overwork: cellular communication network factor 3 for life in cartilage

Kubota S, Kawaki H, Perbal B, Takigawa M, Kawata K, Hattori T, Nishida T.,

J Cell Commun Signal., 17(2) 353-359, 2023
Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration

Satoshi Kubota, Kazumi Kawata, Takako Hattori, Takashi Nishida

International journal of molecular sciences, 23(11), Feb, 2022 Peer-reviewed
Odontoblast differentiation is regulated by an interplay between primary cilia and the canonical Wnt pathway

Kazumi Kawata, Keishi Narita, Ayako Washio, Chiaki Kitamura, Tatsuji Nishihara, Satoshi Kubota, Sen Takeda

Bone, 150 116001-116001, Sep, 2021 Peer-reviewedLead authorCorresponding author
Cellular communication network factor 3 in cartilage development and maintenance

Satoshi Kubota, Harumi Kawaki, Bernard Perbal, Kazumi Kawata, Takako Hattori, Takashi Nishida

Journal of Cell Communication and Signaling, Jun 14, 2021 Peer-reviewed
RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions

Tomomi Mizukawa, Takashi Nishida, Sho Akashi, Kazumi Kawata, Sumire Kikuchi, Harumi Kawaki, Masaharu Takigawa, Hiroshi Kamioka, Satoshi Kubota

Journal of Cellular Physiology, 236(10) 6884-6896, Mar 3, 2021 Peer-reviewed
Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1

Abdellatif Elseoudi, Takashi Nishida, Tomomi Mizukawa, Takako Hattori, Kazumi Kawata, Eman A. Taha, Masaharu Takigawa, Satoshi Kubota

Journal of Cell Communication and Signaling, 15(1) 81-91, Mar, 2021 Peer-reviewed
Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis

Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of Oral Biosciences, 62(3) 280-288, Sep, 2020 Peer-reviewed
Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes.

Satoshi Kubota, Takanori Ishikawa, Kazumi Kawata, Takako Hattori, Takashi Nishida

International journal of molecular sciences, 21(5), Feb 25, 2020 Peer-reviewed
Regulatory Roles of HSP90-Rich Extracellular Vesicles

Takanori Eguchi, Kisho Ono, Kazumi Kawata, Kuniaki Okamoto, Stuart K. Calderwood

Heat Shock Proteins, 3-17, 2019
A Tumor Suppressor Gene Product, Platelet-Derived Growth Factor Receptor-Like Protein Controls Chondrocyte Proliferation and Differentiation

Kazumi Kawata, Satoshi Kubota, Takanori Eguchi, Eriko Aoyama, Norifumi H. Moritani, Morihiko Oka, Harumi Kawaki, Masaharu Takigawa

JOURNAL OF CELLULAR BIOCHEMISTRY, 118(11) 4033-4044, Nov, 2017 Peer-reviewedLead author
CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes

Aya Maeda-Uematsu, Satoshi Kubota, Harumi Kawaki, Kazumi Kawata, Yoshiaki Miyake, Takako Hattori, Takashi Nishida, Norifumi Moritani, Karen M. Lyons, Seiji Iida …

JOURNAL OF CELLULAR BIOCHEMISTRY, 115(5) 854-865, May, 2014 Peer-reviewed
Novel role of miR-181a in cartilage metabolism.

Kumi Sumiyoshi, Satoshi Kubota, Toshihiro Ohgawara, Kazumi Kawata, Tarek Abd El Kader, Takashi Nishida, Nao Ikeda, Tsuyoshi Shimo, Takashi Yamashiro, Masaharu Takigawa

Journal of cellular biochemistry, 114(9) 2094-100, Sep, 2013 Peer-reviewed
Role of LRP1 in transport of CCN2 protein in chondrocytes

Kazumi Kawata, Satoshi Kubota, Takanori Eguchi, Eriko Aoyama, Norifumi H. Moritani, Seiji Kondo, Takashi Nishida, Masaharu Takigawa

JOURNAL OF CELL SCIENCE, 125(12) 2965-2972, Jun, 2012 Peer-reviewedLead author
Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes

Kawata., K, Kubota, S, Eguchi, T, Aoyama, E, Moritani, N, Kondo, S, Nishida, T, Takigawa, M

J Cell Sci, 15 2965-2972, 2012
Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells

Yoshiaki Miyake, Takayuki Furumatsu, Satoshi Kubota, Kazumi Kawata, Toshifumi Ozaki, Masaharu Takigawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 409(2) 247-252, Jun, 2011 Peer-reviewed
Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells

Kumi Sumiyoshi, Satoshi Kubota, Toshihiro Ohgawara, Kazumi Kawata, Takashi Nishida, Tsuyoshi Shimo, Takashi Yamashiro, Masaharu Takigawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 402(2) 286-290, Nov, 2010 Peer-reviewed
Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN2

Kumi Sumiyoshi, Satoshi Kubota, Rika A. Furuta, Kazuta Yasui, Eriko Aoyama, Harumi Kawaki, Kazumi Kawata, Toshihiro Ohgawara, Takashi Yamashiro, Masaharu Takigawa

JOURNAL OF CELL COMMUNICATION AND SIGNALING, 4(1) 5-14, Mar, 2010 Peer-reviewed
学生のリアルタイム評価を応用した授業内容改善FDシステムの開発

原哲也, 児玉(島津)千恵, 河田かずみ, 白嶋章, 皆木省吾

日本歯科医学教育学会雑誌, 26(1), 2010 Peer-reviewed
Role of the Low-Density Lipoprotein Receptor-Related Protein-1 in Regulation of Chondrocyte Differentiation

Kazumi Kawata, Satoshi Kubota, Takanori Eguchi, Norifumi H. Moritani, Tsuyoshi Shimo, Seiji Kondo, Takashi Nishida, Shogo Minagi, Masaharu Takigawa

JOURNAL OF CELLULAR PHYSIOLOGY, 222(1) 138-148, Jan, 2010 Peer-reviewedLead author

Misc.

骨・軟骨組織における一次繊毛

河田かずみ

腎と透析, 87(5), Nov 25, 2019 Lead author
マルチに働く硬組織の一次繊毛ー一次繊毛は細胞を並べている？

河田かずみ

実験医学, 2018 Lead author
CCN2/CTGFのシグナル/トランスサイトーシス受容体としてのLRP1

河田かずみ, 久保田聡, 滝川正春

生体の科学, 2013 Lead author

Books and Other Publications

Gene Expression Analysis of CCNs Along with Odontoblastic Differentiation In Vivo

Springer, 2023
Regulatory Roles Of HSP90-rich Extracellular Vesicles. in Heat Shock Protein 90 in Human Diseases and Disorders

Eguchi T, Ono K, Kazumi Kawata K, Okamoto K, Calderwood SK

Springer Nature Switzerland AG, 2019
Analysis of transcytosis of CCN2 by chondrocytes. in Methods in Molecular Biology: CCN Proteins: Methods and Protocols

Kawata K, Kubota S, Takigawa M

Springer, 2016

Presentations

139

軟骨細胞分化においてPPARγが機能する可能性

畚野里紗、河田かずみ、滝川正春、上岡寛、久保田聡

第36回日本軟骨代謝学会, Feb 16, 2024
軟骨細胞分化におけるPPARｇの機能の解明への挑戦

畚野里紗, 河田かずみ, 滝川正春, 上岡寛, 久保田聡

第44回岡山歯学会総会・学術集会, Dec 10, 2023
Intraflagellar transport protein 88によるHippo経路を介した象牙芽前駆細胞増殖制御機構

河田かずみ, 青山絵理子, 滝川正春, 久保田聡

第46回日本分子生物学会年会, Dec 7, 2023
軟⾻細胞におけるCCN2由来circRNAの発現とその⽣成メカニズム‧機能の考察

加藤壮真, 河田かずみ, 田崇, 滝川正春, 飯田征二, 久保田聡

第46回日本分子生物学会年会, Dec 6, 2023
軟骨細胞におけるCCN2由来circRNAの発現とその機能の可能性

加藤壮真, 河田かずみ, 西田崇, 滝川正春, 久保田聡

第65回歯科基礎医学会学術大会, Sep 18, 2023
Intraflagellar transport protein88によるHippo経路と古典的WNT経路を介した象牙芽前駆細胞増殖制御の可能性

河田かずみ, 青山絵理子, 滝川正春, 久保田聡

第65回歯科基礎医学会学術大会, Sep, 2023
軟骨細胞増殖・分化におけるHippo pathwayを介したCCNsとPDGFRLの関与

河田かずみ, 青山絵理子, 滝川正春, 久保田聡

第14回日本CCNファミリー研究会, Sep 2, 2023
軟骨細胞における CCN2 由来環状 RNA の発現とその機能の検証

加藤壮真、河田かずみ、西田崇、水川朋美、滝川正春、飯田征二、久保田聡

第14回日本CCNファミリー研究会, Sep 2, 2023
軟骨細胞での生物学的作用におけるHippo pathwayを介したCCNsとPDGFRLの関与

河田かずみ, 青山絵理子, 滝川正春, 久保田聡

第41回日本骨代謝学会学術集会, Jul 28, 2023
軟骨細胞における CCN2 由来環状 RNA の発現とその機能の探索

加藤壮真、河田かずみ、西田崇、水川朋美、滝川正春、飯田征二、久保田聡

第41回日本骨代謝学会学術集会, Jul 28, 2023
軟骨細胞におけるCCN2由来環状RNAの探索とその機能

加藤壮真, 河田かずみ, 水川朋美, 西田崇, 久保田聡

第35回日本軟骨代謝学会, Mar 4, 2023
軟骨細胞におけるCCN2由来環状RNAの発現

加藤壮真, 河田かずみ, 西田崇, 水川朋美, 久保田聡

第64回歯科基礎医学会学術大会, Sep 19, 2022
Intraflagellar transport protein 88による象牙芽前駆細胞増殖制御機構

河田かずみ, 青山絵理子, 久保田聡

第64回歯科基礎医学会学術大会, Sep 18, 2022
軟骨細胞における CCN2 由来環状 RNA の発現とその機能の探索

加藤壮真, 河田かずみ, 西田崇, 水川朋美, 飯田征二, 久保田聡

第13回日本CCNファミリー研究会, Sep 3, 2022
象牙芽前駆細胞におけるIFT88の機能 -CCNsの関与の可能性-

河田かずみ, 成田啓之, 青山絵理子, 北村知昭, 西原達次, 滝川正春, 竹田扇, 久保田聡

第13回日本CCNファミリー研究会, Sep 3, 2022
軟骨細胞における転写因子RFX1を介したCCN3の発現制御機構とその役割

水川朋美, 西田崇, 明石翔, 河田かずみ, 菊池菫, 川木晴美, 滝川正春, 上岡寛, 久保田聡

第34回日本軟骨代謝学会, Feb, 2022
軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与

河田かずみ, 青山絵理子, 滝川正春, 久保田聡

第44回日本分子生物学会年会, Dec 2, 2021
軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明

水川朋美, 西田崇, 明石翔, 河田かずみ, 菊池菫, 川木晴美, 滝川正春, 上岡寛, 久保田聡

第94回日本生化学会大会, Nov, 2021
飢餓状態の軟骨細胞におけるRFX1を介したCCN3の誘導機構とその意義

水川朋美, 西田崇, 河田かずみ, 川木晴美, 滝川正春, 久保田聡

第39回日本骨代謝学会学術集会, Oct, 2021
CCN2、CCN3とPDGFRLの軟骨細胞への作用におけるHippo pathwayの関与

河田かずみ, 青山絵理子, 滝川正春, 久保田, 聡

第12回日本CCNファミリー研究会, Sep, 2021

Teaching Experience

Research Projects

Development of dropletomics that clarifies transcriptional regulation under liquid-liquid phase separation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Jun, 2023 - Mar, 2027
象牙芽細胞の表面に突き出た細胞小器官の機能解析と象牙質再生への応用

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

高江洲かずみ, 服部高子, 青山絵理子, 滝川正春, 西田崇, 久保田聡
Regulation of skeletogenesis by long noncoding RNAs through CCN2

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
長鎖非コードRNAによる骨細胞メカニカルストレス応答制御機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

石川崇典, 宮脇正一, 前田綾, 大賀泰彦, 久保田聡, 西田崇, 服部高子, 高江洲かずみ
新規軟骨老化促進因子CCN3の加齢に伴った発現誘導と細胞周期停止機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

服部高子, 久保田聡, 西田崇, 高江洲かずみ
Inverse genetics: A new methodology for the identification of key genes of somatic cell differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2023
CCN２の転写因子様機能を介した線維症のキープレイヤー筋線維芽細胞分化機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

西田崇, 滝川正春, 久保田聡, 服部高子, 青山絵理子, 高江洲かずみ
細胞アンテナによる象牙質再生への道を拓く基礎研究

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

高江洲かずみ, 服部高子, 青山絵理子, 滝川正春, 西田崇, 久保田聡
Regulation of CCN2 by an endogenous UTR blocker and its biological significance

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Kubota Satoshi
象牙芽前駆細胞におけるIFT88を介した細胞増殖制御機構の解明

女性教員支援助成金【研究費配分型】, 岡山大学ダイバーシティ推進本部男女共同参画室, 2021
Mechanism of onset of osteoarthritis caused by obesity and regulatory effects of CCN2

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Nishida Takashi
New potential of CCN2: Functional evaluation as a Warburg effector

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Kubota Satoshi
Role of Sox9 and its ubiquitin ligase on the Circadian growth rhythm in chondrocytes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Hattori Takako
The investigation of the mechanism of regular arrangement of odontoblasts via extracellular environment sensing sensors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Takaesu Kazumi
The presence and its significance of non-canonical action of decoy receptors

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

TAKIGAWA MASAHARU, KUBOTA SATOSHI, AOYAMA ERIKO, NISHIDA TAKASHI, HATTORI TAKAKO, TAKAESU KAZUMI
Development of a new regenerative treatment for teeth through cellular antennas

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KAWATA Kazumi
細胞「外」小器官を介した象牙芽細胞の規則的配列機構の解明

復職支援助成金, 2015

河田かずみ
変形性関節症発症に於ける一次繊毛の役割 -新規治療法の開発に向けて -

第28回基礎医学医療研究助成金, 公益財団法人金原一郎記念医学医療振興財団, 2013

河田かずみ
Prevention of dementia by the recovery of the mastication

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

HARA Tetsuya, NAKANISHI Tohru, KODAMA Chie, KAWATA Kazumi, MINAGI Shogo
Function of the low-density lipoprotein receptor related protein 1 (LRP1) as a transporter of CCN2/connective tissue growth factor (CTGF) in chondrocytes

特別教育研究経費「口腔からQOL向上を目指す連携研究」国際学会等派遣, 2011

河田かずみ

Media Coverage

ヒューマニエンス～40億年のたくらみ～ミクロの毛細胞を指揮する司令塔

NHK BSP/BS4K, Nov, 2022 TV or radio program

Profile Information

Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Research Projects

Media Coverage

Menu

Coauthors