論文

2006年6月

Possible role of LRP1, a CCN2 receptor, in chondrocytes

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • K Kawata
  • ,
  • T Eguchi
  • ,
  • S Kubota
  • ,
  • H Kawaki
  • ,
  • M Oka
  • ,
  • S Minagi
  • ,
  • M Takigawa

345
2
開始ページ
552
終了ページ
559
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2006.04.109
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Low density lipoprotein receptor (LDLR)-related protein 1 (LRP1/CD91) is one of the receptors of CCN2 that conducts endochondral ossification and cartilage repair. LRP1 is a well-known endocytic receptor, but its distribution among chondrocytes remains to be elucidated. We herein demonstrate for the first time that the distribution of LRP1 in chondrocytes except for hypertrophic chondrocytes in vivo and in vitro. Interestingly, the LRP1 levels were higher in mature chondrocytic HCS-2/8 and osteoblastic SaOS-2 than in other cells, whereas the other LDLR family members involved in ossification were detected at lower levels in HCS-2/8. It was interesting to note that in HCS-2/8, LRP1 was observed not only on the cell surface and in the cytoplasm, but also in the nucleus. Exogenously added CCN2 was incorporated into HCS-2/8, which was partially co-localized with LRP1, and targeted to the recycling endosomes and nucleus as well as the lysosomes. These findings suggest specific roles of LRP1 in cartilage biology. (c) 2006 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 30

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2006.04.109
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000238001600002&DestApp=WOS_CPL

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