論文

査読有り
2010年11月

Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Kumi Sumiyoshi
  • ,
  • Satoshi Kubota
  • ,
  • Toshihiro Ohgawara
  • ,
  • Kazumi Kawata
  • ,
  • Takashi Nishida
  • ,
  • Tsuyoshi Shimo
  • ,
  • Takashi Yamashiro
  • ,
  • Masaharu Takigawa

402
2
開始ページ
286
終了ページ
290
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2010.10.016
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

The process of endochondral ossification is strictly regulated by a variety of extracellular and intracellular factors. Recently, it has become recognized that specific miRNAs are involved in this process by regulating the expression of the relevant genes at the post-transcriptional level. In this present study we obtained the first evidence of the involvement of a specific micro RNA (miRNA) in the regulation of the chondrocyte phenotype during late stages of differentiation. By use of the microarray technique, miR-1 was identified as this miRNA, the expression of which was most repressed upon hypertrophic differentiation. Transfection of human chondrocytic HCS-2/8 cells and chicken normal chondrocytes with miR-1 led to repressed expression of aggrecan, the major cartilaginous proteoglycan gene. Therefore, miR-1 was found to be involved in the regulation of the chondrocytic phenotype and thus to play an important role in chondrocytes during the late stage of the differentiation process, maintaining the integrity of the cartilage tissue. (C) 2010 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 29

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2010.10.016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20937250
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000284862300021&DestApp=WOS_CPL

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