論文

査読有り
2011年6月

Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Yoshiaki Miyake
  • ,
  • Takayuki Furumatsu
  • ,
  • Satoshi Kubota
  • ,
  • Kazumi Kawata
  • ,
  • Toshifumi Ozaki
  • ,
  • Masaharu Takigawa

409
2
開始ページ
247
終了ページ
252
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2011.04.138
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Anterior cruciate ligament (ACL)-to-bone interface serves to minimize the stress concentrations that would arise between two different tissues. Mechanical stretch plays an important role in maintaining cell-specific features by inducing CCN family 2/connective tissue growth factor (CCN2/CTGF). We previously reported that cyclic tensile strain (CTS) stimulates alpha 1(I) collagen (COL1A1) expression in human ACL-derived cells. However, the biological function and stress-related response of CCN2/CTGF were still unclear in ACL fibroblasts. In the present study, CCN2/CTGF was observed in ACL-to-bone interface, but was not in the midsubstance region by immunohistochemical analyses. CTS treatments induced higher increase of CCN2/CTGF expression and secretion in interface cells compared with midsubstance cells. COL1A1 expression was not influenced by CCN2/CTGF treatment in interface cells despite CCN2/CTGF stimulated COL1A1 expression in midsubstance cells. However, CCN2/CTGF stimulated the proliferation of interface cells. Our results suggest that distinct biological function of stretch-induced CCN2/CTGF might regulate region-specific phenotypes of ACL-derived cells. (C) 2011 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 14

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2011.04.138
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21569762
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000291779100017&DestApp=WOS_CPL

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