論文

2006年5月

Recent advances in mammalian RFamide peptides: The discovery and functional analyses of PrRP, RFRPs and QRFP

Peptides
  • Shoji Fukusumi
  • ,
  • Ryo Fujii
  • ,
  • Shuji Hinuma

27
5
開始ページ
1073
終了ページ
1086
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.peptides.2005.06.031

Since the first discovery of a peptide with RFamide structure at its C-terminus (i.e., an RFamide peptide) from an invertebrate in 1977, numerous studies on RFamide peptides have been conducted, and a variety have been identified in various phyla throughout the animal kingdom. The first reported mammalian RFamide peptides were neuropeptide FF (NPFF) and neuropeptide AF (NPAF) in 1985. However, for many years after this, no new novel RFamide peptides were identified in mammals. A breakthrough in discovering mammalian RFamide peptides was made possible by reverse pharmacology on the basis of orphan G protein-coupled receptor (GPCR) research. The first report of an RFamide peptide identified from orphan GPCR research was prolactin (PRL)-releasing peptide (PrRP) in 1998. To date, a total of five RFamide peptide genes have been discovered in mammals. Orphan GPCR research has contributed considerably to the identification of these peptides and their receptor genes. This paper examines these mammalian RFamide peptides focusing especially on PrRP, RFamide-related peptides (RFRPs) and, the most recently identified, pyroglutamylated RFamide peptide (QRFP), the discovery of all of which the authors were at least partly involved in. We review here the strategies employed for the identification of these peptides and examine their characteristics, tissue distribution, receptors and functions. © 2006 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.peptides.2005.06.031
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16500002
ID情報
  • DOI : 10.1016/j.peptides.2005.06.031
  • ISSN : 0196-9781
  • PubMed ID : 16500002
  • SCOPUS ID : 33646132535

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