KAZUNORI KUME

Profile Information

Affiliation: Associate Professor, Graduate School of Integrated Scieces for Life, Hiroshima University

Researcher number: 80452613
ORCID ID: https://orcid.org/0000-0002-0613-8081
J-GLOBAL ID: 201801000962706272
researchmap Member ID: 7000028287

Our research goal is to understand the control mechanisms of cell structure that guarantees the functions of eukaryotic cells. Research topics we focus on are the control mechanism of nuclear size and the control mechanism of cell morphology.

Research Areas

Research History

Apr, 2019 - Present

Hiroshima University
Apr, 2007 - Mar, 2019

Graduate School of Advanced Sciences of Matter, Hiroshima University
Jan, 2012 - Dec, 2014

客員研究員, 英国癌研究所

Education

Apr, 2004 - Mar, 2007

Hiroshima University
Apr, 2000 - Mar, 2004

Hiroshima University

Awards

Mar, 2019

農芸化学奨励賞, 日本農芸化学会

Papers

Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast.

Takayuki Koyano, Takahiro Fujimoto, Kaori Onishi, Makoto Matsuyama, Masaki Fukushima, Kazunori Kume

Genes to cells : devoted to molecular & cellular mechanisms, Sep 18, 2023
Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast

Scotchman, Elizabeth, Kume, Kazunori, Navarro, Francisco J., Nurse, Paul

JOURNAL OF CELL SCIENCE, 134(3), Feb, 2021 Peer-reviewed
Cellulose Nanofiber and Magnetic Nanoparticles as Building Blocks Constructing Biomass-Based Porous Structured Particles and Their Protein Adsorption Performance

Rahmatika, Annie M., Toyoda, Youhei, Nguyen, Tue T., Goi, Yohsuke, Kitamura, Takeo, Morita, Yuko, Kume, Kazunori, Ogi, Takashi

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8(50) 18686-18695, Dec 21, 2020 Peer-reviewed
Control of cellular organization and its coordination with the cell cycle

Kume, Kazunori

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84(5) 869-875, May 3, 2020 Peer-reviewed
SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae.

Koji Masumura, Sachi Matsukami, Kumiko Yonekita, Muneyoshi Kanai, Kazunori Kume, Dai Hirata, Masaki Mizunuma

Bioscience, biotechnology, and biochemistry, 83(8) 1473-1476, Aug, 2019 Peer-reviewed
Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast

Kume, Kazunori, Kaneko, Sayuri, Nishikawa, Kenji, Mizunuma, Masaki, Hirata, Dai

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503(2) 1160-1167, Sep 5, 2018 Peer-reviewed
A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast

Masashi Yukawa, Tomoki Kawakami, Masaki Okazaki, Kazunori Kume, Ngang Heok Tang, Takashi Toda

MOLECULAR BIOLOGY OF THE CELL, 28(25) 3647-3659, Dec, 2017 Peer-reviewed
Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast

Kazunori Kume, Tomoyo Hashimoto, Masashi Suzuki, Masaki Mizunuma, Takashi Toda, Dai Hirata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 491(4) 883-889, Sep, 2017 Peer-reviewed
A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control

Kazunori Kume, Helena Cantwell, Frank R. Neumann, Andrew W. Jones, Ambrosius P. Snijders, Paul Nurse

PLOS GENETICS, 13(5), May, 2017 Peer-reviewed
Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK

Takafumi Ogawa, Ryohei Tsubakiyama, Muneyoshi Kanai, Tetsuya Koyama, Tsutomu Fujii, Haruyuki Iefuji, Tomoyoshi Soga, Kazunori Kume, Tokichi Miyakawa, Dai Hirata …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(42) 11913-11918, Oct, 2016 Peer-reviewed
Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801

Tetsuya Goshima, Ryo Nakamura, Kazunori Kume, Hiroki Okada, Eri Ichikawa, Hiroyasu Tamura, Hirokazu Hasuda, Masaaki Inahashi, Naoto Okazaki, Takeshi Akao …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(8) 1657-1662, Aug, 2016 Peer-reviewed
Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

Illyce Nunez, Marbelys Rodriguez Pino, David J. Wiley, Maitreyi Das, Chuan Chen, Tetsuya Goshima, Kazunori Kume, Dai Hirata, Takashi Toda, Fulvia Verde

ELIFE, 5, Jul, 2016 Peer-reviewed
Elutriation for Cell Cycle Synchronization in Fission Yeast.

Kazunori Kume

Methods in molecular biology (Clifton, N.J.), 1342 149-55, 2016
Casein kinase 1 gamma acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast

Takayuki Koyano, Karin Barnouin, Ambrosius P. Snijders, Kazunori Kume, Dai Hirata, Takashi Toda

GENES TO CELLS, 20(12) 1046-1058, Dec, 2015 Peer-reviewed
The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts

Kun Wan, Haruka Kawara, Tomoyuki Yamamoto, Kazunori Kume, Yukari Yabuki, Tetsuya Goshima, Kenji Kitamura, Masaru Ueno, Muneyoshi Kanai, Dai Hirata …

YEAST, 32(9) 607-614, Sep, 2015 Peer-reviewed
Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity

Hiroyasu Tamura, Hiroki Okada, Kazunori Kume, Takayuki Koyano, Tetsuya Goshima, Ryo Nakamura, Takeshi Akao, Hitoshi Shimoi, Masaki Mizunuma, Yoshikazu Ohya …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(7) 1191-1199, Jul, 2015 Peer-reviewed
Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin

Kazunori Kume, Takayuki Koyano, Junpei Takata, Ko Wakabayashi, Masaki Mizunuma, Tokichi Miyakawa, Dai Hirata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(5) 790-794, May, 2015 Peer-reviewed
Casein Kinase 1 gamma Ensures Monopolar Growth Polarity under Incomplete DNA Replication Downstream of Cds1 and Calcineurin in Fission Yeast

Takayuki Koyano, Manabu Konishi, Sophie G. Martin, Yoshikazu Ohya, Dai Hirata, Takashi Toda, Kazunori Kume

MOLECULAR AND CELLULAR BIOLOGY, 35(9) 1533-1542, May, 2015 Peer-reviewed
A Method for Rapid Identification of the Sake Yeast with High Ethyl Caproate-producing Ability

TAMURA Hiroyasu, HIRATA Dai, KURIBAYASHI Takashi, KUME Kazunori, GOSHIMA Tetsuya, NAKAMURA Ryo, WATANABE Ken-ichi, AKAO Ken, SHIMOI Hitoshi, MIZINUMA Masaki

JOURNAL OF THE BREWING SOCIETY OF JAPAN, 110(12) 820-826, 2015
Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing

Yoshihiko Anzawa, Kenji Satoh, Yuko Satoh, Satomi Ohno, Tsutomu Watanabe, Kazuaki Katsumata, Kazunori Kume, Ken-ichi Watanabe, Masaki Mizunuma, Dai Hirata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78(11) 1954-1962, Nov, 2014 Peer-reviewed
Isolation of a Non-Urea-Producing Sake Yeast Strain Carrying a Discriminable Molecular Marker

Takashi Kuribayashi, Hiroyasu Tamura, Keigo Sato, Yoshihito Nabekura, Toshio Aoki, Yoshihiko Anzawa, Kazuaki Katsumata, Shunji Ohdaira, Susumu Yamashita, Kazunori Kume …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(12) 2505-2509, Dec, 2013 Peer-reviewed
Polishing Properties of Sake Rice Koshitanrei for High-Quality Sake Brewing

Yoshihiko Anzawa, Yoshihito Nabekura, Kenji Satoh, Yuko Satoh, Satomi Ohno, Tsutomu Watanabe, Mitsuoki Kaneoke, Kazunori Kume, Masaki Mizunuma, Ken-ichi Watanabe …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(10) 2160-2165, Oct, 2013 Peer-reviewed
Fission Yeast Leucine-Rich Repeat Protein Lrp1 Is Essential for Cell Morphogenesis as a Component of the Morphogenesis Orb6 Network (MOR)

Kazunori Kume, Shunsuke Kubota, Takayuki Koyano, Muneyoshi Kanai, Masaki Mizunuma, Takashi Toda, Dai Hirata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(5) 1086-1091, May, 2013 Peer-reviewed
Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast.

Masaki Mizunuma, Ryohei Tsubakiyama, Takafumi Ogawa, Atsunori Shitamukai, Yoshifumi Kobayashi, Tomomi Inai, Kazunori Kume, Dai Hirata

The Journal of biological chemistry, 288(15) 10558-66, Apr 12, 2013 Peer-reviewed
Evidence of antagonistic regulation of restart from G(1) delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast.

Masaki Mizunuma, Takafumi Ogawa, Tetsuya Koyama, Atsunori Shitamukai, Ryohei Tsubakiyama, Tadamasa Komaruyama, Toshinaga Yamaguchi, Kazunori Kume, Dai Hirata

Bioscience, biotechnology, and biochemistry, 77(10) 2002-7, 2013 Peer-reviewed
Implication of Ca2+ in the Regulation of Replicative Life Span of Budding Yeast

Ryohei Tsubakiyama, Masaki Mizunuma, Anri Gengyo, Josuke Yamamoto, Kazunori Kume, Tokichi Miyakawa, Dai Hirata

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(33) 28681-28687, Aug, 2011 Peer-reviewed
Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation

Seiji Kawamoto, Mitsuoki Kaneoke, Kayo Ohkouchi, Yuichi Amano, Yuki Takaoka, Kazunori Kume, Tsunehiro Aki, Susumu Yamashita, Ken-ichi Watanabe, Motoni Kadowaki …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75(1) 140-144, Jan, 2011 Peer-reviewed
Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.

Kume Kazunori, Koyano Takayuki, Kanai Muneyoshi, Toda Takashi, Hirata Dai

Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth., 13(3) 234-U357, 2011 Peer-reviewed
Fission Yeast Germinal Center (GC) Kinase Ppk11 Interacts with Pmo25 and Plays an Auxiliary Role in Concert with the Morphogenesis Orb6 Network (MOR) in Cell Morphogenesis

Tetsuya Goshima, Kazunori Kume, Takayuki Koyano, Yoshikazu Ohya, Takashi Toda, Dai Hirata

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(45) 35196-35205, Nov, 2010 Peer-reviewed
The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe

Samriddha Ray, Kazunori Kume, Sneha Gupta, Wanzhong Ge, Mohan Balasubramanian, Dai Hirata, Dannel McCollum

JOURNAL OF CELL BIOLOGY, 190(5) 793-805, Sep, 2010 Peer-reviewed
Search for Kinases Related to Transition of Growth Polarity in Fission Yeast

Takayuki Koyano, Kazunori Kume, Manabu Konishi, Takashi Toda, Dai Hirata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(5) 1129-1133, May, 2010 Peer-reviewed
A method for Pmo25-associated kinase assay in fission yeast: The activity is dependent on two GC kinases Nak1 and Sid1

Kazunori Kume, Tetsuya Goshima, Kohji Miyahara, Takashi Toda, Dai Hirata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(2) 615-617, Feb, 2007 Peer-reviewed
The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint

K Asakawa, K Kume, M Kanai, T Goshima, K Miyahara, S Dhut, WW Tee, D Hirata, T Toda

MOLECULAR BIOLOGY OF THE CELL, 17(3) 1421-1435, Mar, 2006 Peer-reviewed
Mal3, the fission yeast EB1 homologue, cooperates with Bub1 spindle checkpoint to prevent monopolar attachment

K Asakawa, M Toya, M Sato, M Kanai, K Kume, T Goshima, MA Garcia, D Hirata, T Toda

EMBO REPORTS, 6(12) 1194-1200, Dec, 2005 Peer-reviewed
Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis

M Kanai, K Kume, K Miyahara, K Sakai, K Nakamura, K Leonhard, DJ Wiley, F Verde, T Toda, D Hirata

EMBO JOURNAL, 24(17) 3012-3025, Sep, 2005 Peer-reviewed
Effect of ethanol on cell growth of budding yeast: Genes that are important for cell growth in the presence of ethanol

S Kubota, Takeo, I, K Kume, M Kanai, A Shitamukai, M Mizunuma, T Miyakawa, H Shimoi, H Iefuji, D Hirata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(4) 968-972, Apr, 2004 Peer-reviewed

Misc.

Nuclear Size Control in Eukaryotic Cells: What is the Mechanism That Senses Cell Size and Controls Nuclear Size?

久米一規, 久米一規

化学と生物, 60(8), 2022
Nuclear size control in fission yeast and its application to nuclear size operation

藤本尭玄, 久米一規, 久米一規

月刊細胞, 54(8), 2022
Cell-size-coordinated nuclear size control mechanism and its application to nuclear size manipulation technology

藤本尭玄, 久米一規, 久米一規

アグリバイオ, 6(13), 2022
1P-151 Isolation of a spontaneous cerulenin-resistant sake yeast with high ethyl caproate-producing ability

Tamura Hiroyasu, Kuribayashi Takashi, Kume Kazunori, Goshima Tetsuya, Nakamura Ryo, Ichikawa Eri, Watanabe Ken-ichi, Akao Takeshi, Shimoi Hitoshi, Mizunuma Masaki …

67 126-126, 2015
DNA複製と細胞極性をつなぐ経路:癌細胞の異常な形を理解するヒント!

久米一規, 平田大

細胞工学, 30(8), 2011

Professional Memberships

Research Projects

進化上保存された核サイズ恒常性維持機構の全容解明とその生理学的意義の検証

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2024

久米一規, 原裕貴
オルガネラ間サイズネットワーク機構の実験的検証

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2024

原裕貴, 木村健二, 久米一規
核サイズの人為的操作法の開発

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2020 - Mar, 2023

久米一規
進化上保存された細胞極性形成ネットワークによる新規の微小管制御機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2017 - Mar, 2020

久米一規
Study on nuclear size control

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kume Kazunori, Nurse Paul
Cell morphogenesis network regulates coordination between cell morphogenesis and cell growth

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2011

KUME Kazunori
Basic and applied research on cell polarity control yeast

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2011

HIRATA Dai, MIZUNUMA Masaki, KUME Kazunori
細胞形態形成と細胞増殖とを連携制御する細胞極性ネットワーク

科学研究費助成事業若手研究(スタートアップ), 若手研究(スタートアップ), 日本学術振興会, 2007 - 2008

久米一規
細胞の形態形成と増殖とを連携制御する細胞極性ネットワーク

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2006 - 2008

久米一規