論文

査読有り
2013年5月

Fission Yeast Leucine-Rich Repeat Protein Lrp1 Is Essential for Cell Morphogenesis as a Component of the Morphogenesis Orb6 Network (MOR)

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  • Kazunori Kume
  • ,
  • Shunsuke Kubota
  • ,
  • Takayuki Koyano
  • ,
  • Muneyoshi Kanai
  • ,
  • Masaki Mizunuma
  • ,
  • Takashi Toda
  • ,
  • Dai Hirata

77
5
開始ページ
1086
終了ページ
1091
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1271/bbb.130064
出版者・発行元
TAYLOR & FRANCIS LTD

In eukaryotes, cell morphogenesis is regulated coordinately with the cell cycle. In fission yeast, the morphogenesis network MOR (morphogenesis Orb6 network) consists of 5 conserved proteins, Pmo25, Nak1, Mor2, Orb6, and Mob2, and is essential for cell polarity control and cell separation following cytokinesis. Here we show that the conserved leucine-rich repeat protein Lrp1 is required for cell morphogenesis as a newly recognized component of MOR. Lrp1 has 4 leucine-rich repeats in its N-terminus and is a homolog of the budding yeast Sog2, which is a component of the RAM network (regulation of Ace2 activity and cellular morphogenesis). Lrp1 was essential for both cell growth and cell morphogenesis as were the other MOR components. Lrp1 was localized to the SPBs (spindle pole bodies, the yeast equivalent of the animal centrosome) throughout the cell cycle and to the medial ring during cytokinesis. Lrp1 interacted with Nak1 and was important for Orb6 kinase activity. Thus Lrp1 proved to function upstream of Orb6 in cell morphogenesis.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1271/bbb.130064
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000320414900031&DestApp=WOS_CPL
ID情報
  • DOI : 10.1271/bbb.130064
  • ISSN : 0916-8451
  • eISSN : 1347-6947
  • Web of Science ID : WOS:000320414900031

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