Apr, 2014 - Mar, 2017
Study on nuclear size control
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
- Grant number
- 26660089
- Japan Grant Number (JGN)
- JP26660089
- Grant amount
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- (Total)
- 3,900,000 Japanese Yen
- (Direct funding)
- 3,000,000 Japanese Yen
- (Indirect funding)
- 900,000 Japanese Yen
Nucleus is one of membrane-bound organelles and important for maintenance of genome DNA in eukaryotic cells. Nuclear size, required for nuclear function, is proportional to cell size, resulting in a constant ratio between nuclear and cellular volumes (N/C ratio). However, how this is achieved remains elusive. To understand molecular mechanisms of nuclear size control in eukaryotic cells, we studied N/C ratio mutants using fission yeast, a model organism of eukaryotic cell. We found that properly regulated nucleocytoplasmic transport and membrane growth are critical for appropriate nuclear size control in growing cells. This finding may contribute to understanding a cause of cancer, because cancer cells have enlarged nucleus.
- Link information
- ID information
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- Grant number : 26660089
- Japan Grant Number (JGN) : JP26660089