論文

査読有り 国際誌
2019年9月19日

A Survey of Vaccine-Induced Measles IgG Antibody Titer to Verify Temporal Changes in Response to Measles Vaccination in Young Adults.

Vaccines
  • Hiraku Sasaki
  • ,
  • Tomoko Fukunaga
  • ,
  • Ai Asano
  • ,
  • Yoshio Suzuki
  • ,
  • Yuko Nakanishi
  • ,
  • Junzi Kondo
  • ,
  • Hiroki Ishikawa
  • ,
  • Nobuto Shibata

7
3
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/vaccines7030118

In Japan, sporadic measles cases increased rapidly in 2019 compared to the past six years. To clarify the persistence of immunity against measles in young adults, this study explored the persistence of immunoglobulin G (IgG) antibody titers against the measles virus in 17- to 24-year-old young participants who reside in the Chiba prefecture of Japan. Measles-specific IgG antibody titers, determined by enzyme immunoassay in serum samples collected from 506 participants, were assessed through statistical analyses. Multivariable regression analysis revealed that the distribution of measles IgG antibody titers was significantly correlated with a medical history of measles (P < 0.05), while there was no significant correlation between the number of vaccinations related to measles IgG titers. Furthermore, measles IgG titers tended to decrease, as revealed by the temporal change in IgG titers, during the elapsed period after the last vaccination (P = 0.08). These results indicate that periodic vaccination against measles is required to prevent sporadic measles infection in young and older adults.

リンク情報
DOI
https://doi.org/10.3390/vaccines7030118
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31546797
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789707
ID情報
  • DOI : 10.3390/vaccines7030118
  • PubMed ID : 31546797
  • PubMed Central 記事ID : PMC6789707

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