Hiroaki Hirata

Profile Information

Affiliation: Professor, College of Bioscience and Chemistry Department of Life Science and Biotechnology, Kanazawa Institute of Technology

Researcher number: 90414028
ORCID iD: https://orcid.org/0000-0002-2604-9158
J-GLOBAL ID: 201901014136336343
researchmap Member ID: 7000028580

External link: https://pressio-neurobrain.org

Research Areas

Research Interests

Awards

Apr, 2014

APSselect, American Physiological Society

Papers

Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus.

Madoka Suzuki, Keiko Kawauchi, Hiroaki Machiyama, Hiroaki Hirata, Shin'ichi Ishiwata, Hideaki Fujita

Biotechnology and Bioengineering, Apr 24, 2025 Peer-reviewed
Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse

Kishio Furuya, Hiroaki Hirata, Takeshi Kobayashi, Hiroshi Ishiguro, Masahiro Sokabe

Frontiers in Cell and Developmental Biology, 12 1519642-1519642, Jan 15, 2025 Peer-reviewed
Bioinformatic Analysis of Actin-Binding Proteins in the Nucleolus During Heat Shock

Shinya Taniguchi, Takeru Torii, Toshiyuki Goto, Kohei Takeuchi, Rine Katsumi, Mako Sumida, Sunmin Lee, Sugimoto Wataru, Masaya Gessho, Katsuhiko Itoh …

Genes, 15(12) 1580-1580, Dec 9, 2024 Peer-reviewed
From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission

Hiroki Katsuta, Masahiro Sokabe, Hiroaki Hirata

Frontiers in Cell and Developmental Biology, 12 1444827-1444827, Aug 13, 2024 Peer-reviewedCorresponding author
Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments.

Takeru Torii, Wataru Sugimoto, Katsuhiko Itoh, Natsuki Kinoshita, Masaya Gessho, Toshiyuki Goto, Ikuno Uehara, Wataru Nakajima, Yemima Budirahardja, Daisuke Miyoshi …

Cell Death & Disease, 14(11) 766-766, Nov 25, 2023 Peer-reviewedCorresponding author
Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers

Hiroki Katsuta, Satoru Okuda, Kazuaki Nagayama, Hiroaki Machiyama, Satoru Kidoaki, Masashi Kato, Masahiro Sokabe, Takaki Miyata, Hiroaki Hirata

iScience, 26(3) 106090-106090, Mar, 2023 Peer-reviewedCorresponding author
Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells

Oleg Dobrokhotov, Masaki Sunagawa, Takeru Torii, Shinji Mii, Keiko Kawauchi, Atsushi Enomoto, Masahiro Sokabe, Hiroaki Hirata

Frontiers in Cell and Developmental Biology, 9 728383-728383, Nov 11, 2021 Peer-reviewedCorresponding author
Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines

Kishio Furuya, Hiroaki Hirata, Takeshi Kobayashi, Masahiro Sokabe

Life, 11(8) 851-851, Aug 19, 2021 Peer-reviewed
Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1

Hiroaki Hirata, Oleg Dobrokhotov, Masahiro Sokabe

iScience, 23(11) 101729-101729, Nov, 2020 Peer-reviewedCorresponding author
MMP24 as a Target of YAP Is a Potential Prognostic Factor in Cancer Patients

Wataru Sugimoto, Katsuhiko Itoh, Hiroaki Hirata, Yoshinori Abe, Takeru Torii, Yasumasa Mitsui, Yemima Budirahardja, Nobuyuki Tanaka, Keiko Kawauchi

Bioengineering, 7(1) 18-18, Feb 20, 2020 Peer-reviewed
Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity

T. Miyazaki, Z. Zhao, Y. Ichihara, D. Yoshino, T. Imamura, K. Sawada, S. Hayano, H. Kamioka, S. Mori, H. Hirata …

Science Advances, 5(9) eaau7802-eaau7802, Sep, 2019 Peer-reviewed
DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death

Katsuhiko Itoh, Takahiro Ebata, Hiroaki Hirata, Takeru Torii, Wataru Sugimoto, Keigo Onodera, Wataru Nakajima, Ikuno Uehara, Daisuke Okuzaki, Shota Yamauchi …

Molecules, 24(17) 3175, Sep 1, 2019 Peer-reviewed
Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation

Kimihide Hayakawa, Hiroaki Hirata, Mikhail Samsonov, Masahiro Sokabe

Biochemical and Biophysical Research Communications, Nov, 2018 Peer-reviewed
Dopamine and Serotonin Receptors Cooperatively Modulate Pacemaker Activity of Intestinal Cells of Cajal.

Liu HN, Hirata H, Okuno Y, Okabe M, Furukawa K

The Chinese journal of physiology, 61(5) 302-312, Oct, 2018 Peer-reviewed
Tensile Loads on Tethered Actin Filaments Induce Accumulation of Cell Adhesion-Associated Proteins in Vitro

Daisuke Kiyoshima, Hitoshi Tatsumi, Hiroaki Hirata, Masahiro Sokabe

Langmuir, Sep, 2018 Peer-reviewedCorresponding author
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Oleg Dobrokhotov, Mikhail Samsonov, Masahiro Sokabe, Hiroaki Hirata

Clinical and Translational Medicine, 7(1), Aug, 2018 Peer-reviewedCorresponding author
Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2

Wataru Sugimoto, Katsuhiko Itoh, Yasumasa Mitsui, Takahiro Ebata, Hideaki Fujita, Hiroaki Hirata, Keiko Kawauchi

Cell Adhesion and Migration, 12(2) 101-108, Mar 4, 2018 Peer-reviewed
Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes

Hiroaki Hirata, Mikhail Samsonov, Masahiro Sokabe

Scientific Reports, 7, Apr 13, 2017 Peer-reviewedCorresponding author
Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression

Takahiro Ebata, Yasumasa Mitsui, Wataru Sugimoto, Miho Maeda, Keigo Araki, Hiroaki Machiyama, Ichiro Harada, Yasuhiro Sawada, Hideaki Fujita, Hiroaki Hirata …

BioMed Research International, 2017, 2017 Peer-reviewed
Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration

Zhihai Zhao, Song Hui Tan, Hiroaki Machiyama, Keiko Kawauchi, Keigo Araki, Hiroaki Hirata, Yasuhiro Sawada

Biology Open, 5(4) 499-506, Apr 15, 2016 Peer-reviewed

Misc.

Editorial: Multicellularity: Views from cellular signaling and mechanics

Hiroaki Hirata, Naotaka Nakazawa, Tsuyoshi Hirashima, Andrea Ravasio

Frontiers in Cell and Developmental Biology, 11 1172921-1172921, Mar 13, 2023
Chapter 4. Measurement and Manipulation of Cellular Forces Using Silicone Elastomers

Hiroaki Hirata, Masahiro Sokabe

Biomaterials Science Series, 64-84, 2022
【疾患に挑むメカノバイオロジー循環器、運動器、がん、再生・発生に生体内の力はどうかかわるのか】(第1章)メカニカルストレスが関わる疾患がんのメカノバイオロジー細胞増殖の接触阻害における物理的因子の役割

平田宏聡, Dobrokhotov Oleg, 曽我部正博

実験医学, 38(7) 1153-1159, May, 2020
アクトミオシンファイバーは張力依存的なシグナルを生成するプラットフォームとして機能する

平田宏聡, 曽我部正博

生物物理, 60(2) 089-093, Mar, 2020
Cell mechanosensing underlies homeostasis of multicellular systems

Keiko Nonomura, Hiroaki Hirata

Biophysics and Physicobiology, 17 100-102, 2020
Quantifying tensile force and ERK phosphorylation on actin stress fibers

Hiroaki Hirata, Mukund Gupta, Sri Ram Krishna Vedula, Chwee Teck Lim, Benoit Ladoux, Masahiro Sokabe

Methods in Molecular Biology, 1487 223-234, 2017
Cell and Molecular Mechanics in Health and Disease

Keiko Kawauchi, Hideaki Fujita, Daisuke Miyoshi, Evelyn K. F. Yim, Hiroaki Hirata

BioMed Research International, 2017, 2017
p130Cas-Mediated Regulation of Mechanical Functions of Cells

Sawada, Y., Hirata, H.

Clinical calcium, 26(12) 1743-1749, Nov, 2016
【メカノバイオロジーからメカノメディシンへ】メカノセンシング/シグナリング機構伸展・圧縮センシング

平田宏聡, 曽我部正博

医学のあゆみ, 257(10) 1001-1007, Jun, 2016
生命機能を支えるメカノセンシング接着構造/細胞骨格のメカノセンシング

平田宏聡, 曽我部正博

血管医学, 17(1) 77-85, Mar, 2016
【知る・見る・活かす!シグナリング研究2015 シグナル伝達の要素発見から時空間ダイナミクスへ】(第2章)シグナリングから見た生命現象その破綻と疾患の理解「緊張型」と「緩和型」のメカニカルストレスによる生体恒常性維持

澤田泰宏, 原田伊知郎, 市原克則, 吉野大輔, 吉村耕一, 平田宏聡

実験医学, 33(10) 1617-1625, Jun, 2015
A novel role of actomyosin bundles in ERK signaling

Hiroaki Hirata, Masahiro Sokabe

Communicative and Integrative Biology, 8(2) 1-3, 2015
【新メカノトランスダクション:工学との融合が明らかにする力学刺激センサーの動作とシグナル伝達】細胞-基質間接着のメカノトランスダクション

澤田泰宏, 平田宏聡, 原田伊知郎

細胞工学, 33(9) 950-954, Aug, 2014
Molecular mechanisms underlying the force-dependent regulation of actin-to-ECM linkage at the focal adhesions

Hiroaki Hirata, Masahiro Sokabe, Chwee Teck Lim

Progress in Molecular Biology and Translational Science, 126 135-154, 2014
Zyxin emerges as a key player in the mechanotransduction at cell adhesive structures

Hiroaki Hirata, Hitoshi Tatsumi, Masahiro Sokabe

Communicative & Integrative Biology, 1(2) 192-195, Oct, 2008
細胞内骨格分子の力学的な制御の可視化技術による分析

辰巳仁史, 平田宏聡, 早川公英, 曽我部正博

バイオイメージング, 16(2) 71-72, Oct 5, 2007
Biophysical mechanisms of tension-dependent formation of stress fibers from actin meshwork

H. Hirata, H. Tatsumi, M. Sokabe

Biomechanics at Micro- and Nanoscale Levels, 7281, Jan 1, 2007

Books and Other Publications

細胞のマルチスケールメカノバイオロジー

佐藤, 正明( 工学), 安達, 泰治, 松下, 慎二, 井上, 康博, 平田, 宏聡, 曽我部, 正博, 出口, 真次, 安藤, 譲二, 山本, 希美子, 谷下, 一夫, 須藤, 亮 (Role: Joint author)

森北出版, 2017 (ISBN: 9784627691414)
メカノバイオロジー : 細胞が力を感じ応答する仕組み

曽我部正博 (Role: Contributor)

化学同人, 2015 (ISBN: 9784759817218)

Research Projects

がん細胞塊と３次元細胞外基質との力学相互作用パラドックスと細胞塊成長への効果

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2025 - Mar, 2028

平田宏聡
細胞間引張力の人為操作による表皮がん細胞の増殖抑制・分化誘導法の開拓と分子機序の解明

第38回北國がん基金研究活動助成, 公益財団法人北國がん基金, Sep, 2024 - Mar, 2025

平田宏聡
プレッシオ脳神経科学の促進・発展

科学研究費助成事業, 学術変革領域研究(B), 日本学術振興会, Aug, 2021 - Mar, 2024

野々村恵子, 森松賢順, 平田宏聡, 中澤直高
Compressive stress against brain tumors: its effect on tumor cell growth and the underlying molecular mechanism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, Aug, 2021 - Mar, 2024
Tissue deformation-dependent regulation of cell proliferation: distinct roles of cell-substrate and cell-cell adhesions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
細胞間接着構造に働く力の操作により表皮癌細胞の増殖を抑制する

Grant for Basic Science Research Projects, The Sumitomo Foundation, Nov, 2019 - Mar, 2021
Mechanism for coordination of cell motility and proliferation in epithelial cells: role of intercellular mechanical interaction

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, Aug, 2019 - Mar, 2021

Hirata Hiroaki
細胞-基質間接着蛋白質インテグリン1分子の直接観察・操作による動的特性の研究

Grant-in-Aid for JSPS Fellows, Apr, 2000 - Mar, 2003

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Awards

Papers

Misc.

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