論文

査読有り
2021年11月11日

Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells

Frontiers in Cell and Developmental Biology
  • Oleg Dobrokhotov
  • ,
  • Masaki Sunagawa
  • ,
  • Takeru Torii
  • ,
  • Shinji Mii
  • ,
  • Keiko Kawauchi
  • ,
  • Atsushi Enomoto
  • ,
  • Masahiro Sokabe
  • ,
  • Hiroaki Hirata

9
開始ページ
728383
終了ページ
728383
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fcell.2021.728383
出版者・発行元
Frontiers Media {SA}

<jats:p>Actomyosin contractility regulates various cellular processes including proliferation and differentiation while dysregulation of actomyosin activity contributes to cancer development and progression. Previously, we have reported that actomyosin-generated tension at adherens junctions is required for cell density-dependent inhibition of proliferation of normal skin keratinocytes. However, it remains unclear how actomyosin contractility affects the hyperproliferation ability of cutaneous squamous cell carcinoma (cSCC) cells. In this study, we find that actomyosin activity is impaired in cSCC cells both <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. External application of tensile loads to adherens junctions by sustained mechanical stretch attenuates the proliferation of cSCC cells, which depends on intact adherens junctions. Forced activation of actomyosin of cSCC cells also inhibits their proliferation in a cell-cell contact-dependent manner. Furthermore, the cell cycle arrest induced by tensile loading to adherens junctions is accompanied by epidermal differentiation in cSCC cells. Our results show that the degree of malignant properties of cSCC cells can be reduced by applying tensile loads to adherens junctions, which implies that the mechanical status of adherens junctions may serve as a novel therapeutic target for cSCC.</jats:p>

リンク情報
DOI
https://doi.org/10.3389/fcell.2021.728383
ID情報
  • DOI : 10.3389/fcell.2021.728383
  • ISSN : 2296-634X
  • ORCIDのPut Code : 103167607

エクスポート
BibTeX RIS