2021年5月
Eosinophilic esophagitis and asymptomatic esophageal eosinophilia display similar immunohistological profiles(和訳中)
(一社)日本酸化ストレス学会 Journal of Clinical Biochemistry and Nutrition
- 巻
- 68
- 号
- 3
- 開始ページ
- 246
- 終了ページ
- 252
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3164/jcbn.20-49
<p>Patients with asymptomatic esophageal eosinophilia (aEE) do not exhibit clinical symptoms because of esophageal dysfunction, although they have endoscopic and histological findings similar to those of eosinophilic esophagitis (EoE). The cause of the symptoms and the differences between aEE and EoE are unclear. The aim of this study is to determine whether aEE and EoE are same disease entities by comparing immune-related tissue biomarkers using immunohistological staining. Esophageal biopsy specimens from 61 patients, including 18 with aEE and 43 with EoE, were analyzed. Immunofluorescence staining was performed to quantify the immune-related tissue biomarkers such as major basic protein, eosinophil-derived neurotoxin, eotaxin-3, and immunoglobulin G4. Data are presented as median (interquartile range). There were no significant differences in clinical, endoscopic, or histological features, between patients with aEE and EoE, with the exception of body mass index. There were no significant differences in all immune-related tissue biomarkers between both groups. In conclusions, EoE and aEE displayed similar immunohistological profiles. Hence, they may be similar disease entities with some common pathogenic mechanisms. Our findings suggest that patients with aEE also have histopathological esophageal inflammation.</p>
- リンク情報
-
- DOI
- https://doi.org/10.3164/jcbn.20-49
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/34025028
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129976
- URL
- https://search.jamas.or.jp/index.php?module=Default&action=Link&type=opac&sid=1&sidx=4&config_id=1&bookid=V705180007&doc_id=20210705180007&icon=https%3A%2F%2Fsfx10.usaco.co.jp%2Focu%2Fsfx.gif
- ID情報
-
- DOI : 10.3164/jcbn.20-49
- ISSN : 0912-0009
- PubMed ID : 34025028
- PubMed Central 記事ID : PMC8129976