Kazuhide Takada

Profile Information

Affiliation: Assistant Professor, School of Medicine Department of Medicine, Nihon University

Degree: 博士（医学）(日本大学)

Researcher number: 60848711
J-GLOBAL ID: 201901009356977770
researchmap Member ID: 7000029015

Research Interests

Research Areas

Research History

Apr, 2019 - Present

助教, 病態病理学系微生物学分野, 日本大学医学部

Education

Apr, 2015 - Mar, 2019

病理系感染制御科学, 医学研究科, Nihon University
Apr, 2007 - Mar, 2013

医学科, 医学部, St.Marianna University School of Medicine

Committee Memberships

Dec, 2024 - Present

評議員, 日本生殖免疫学会
Jan, 2024 - Present

U45委員会, 日本臨床免疫学会

Awards

Sep, 2024

Best Oral Presentation Award, Modulation of immune tolerance at the maternal-fetal interface by endometrial microbiota, Asian Congress for Reproductive Immunology 2024
Aug, 2024

The Japan Society for Immunology of Reproduction Young Investigator Award, Modulation of immune tolerance at the maternal-fetal interface by endometrial microbiota

Kazuhide Takada
Mar, 2024

Top Downloaded Article 2022, The association of three doses of the BNT162b2 mRNA vaccine with abnormal bleeding and an irregular menstrual cycle among premenopausal females: A single institute observation study, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Takahiro Namiki, Shihoko Komine-Aizawa, Kazuhide Takada, Chika Takano, Quang Duy Trinh, Satoshi Hayakawa
Feb, 2023

Top Cited Article 2021-2022, Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Satoshi Hayakawa, Shihoko Komine-Aizawa, Kazuhide Takada, Tadashi Kimura, Hideto Yamada
Sep, 2022

大島賞, ヒト不死化腸管上皮細胞株を用いた SARS-CoV-2 複製に対する Lactobacillus の影響の検討, 第 25 回日本臨床腸内微生物学会学術集会

髙田和秀
Apr, 2022

シーサー（best discussant）賞, 日本臨床免疫学会 MWS2022

髙田和秀
Mar, 2022

Top Cited Article 2020-2021, Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Satoshi Hayakawa, Shihoko Komine-Aizawa, Kazuhide Takada, Tadashi Kimura, Hideto Yamada
Apr, 2020

Top Downloaded Paper 2018-2019, Lactobacillus crispatus accelerates re‐epithelialization in vaginal epithelial cell line MS74, American Journal of Reproductive Immunology

Takada K, Komine-Aizawa S, Kuramochi T, Ito S, Trinh QD, Pham NTK, Sasano M, Hayakawa S.
Apr, 2019

2018 JOGR Best Reviewer Award, Journal of Gynecology and Obstetrics Research

Papers

Comparison of adverse events following the second/third dose of BNT162b2 in a medical institute in Japan

Takahiro Namiki, Kazuhide Takada, Satoshi Hayakawa, Shihoko Komine-Aizawa

Heliyon, 10(14) e34347-e34347, Jul, 2024 Peer-reviewedLead author
産婦人科における感染症学～プロからの伝承女性生殖器における細菌叢とその役割

高田和秀, 松田恵里那, 早川智, 川名敬, 相澤志保子[小峯]

日本産婦人科感染症学会誌, 8(1) 72-72, May, 2024
【母子感染の最新知識】総論胎児・胎盤の感染防御機構母子感染の成り立ち

相澤志保子[小峯], 高田和秀, Trinh Duy Quang, 早川智

周産期医学, 54(5) 533-537, May, 2024
Editorial (JSIR2021 Special issue)

Kei Kawana, Atsushi Fukui, Fumihisa Chishima, Kazuhide Takada, Masahiro Itoh

Journal of Reproductive Immunology, 158 103976, Aug, 2023 Invited
Roles of TGF-β1 in Viral Infection during Pregnancy: Research Update and Perspectives.

Quang Duy Trinh, Ngan Thi Kim Pham, Kazuhide Takada, Hiroshi Ushijima, Shihoko Komine-Aizawa, Satoshi Hayakawa

International journal of molecular sciences, 24(7), Mar 30, 2023 Peer-reviewed
Female reproductive tract-organ axes

Takada K, Melnikov GV, Kobayashi R, Komine-Aizawa S, Tsuji MN, Hayakawa S

Frontiers in Immunology, 14 1110001, Jan 31, 2023 Peer-reviewedLead authorCorresponding author
Pathological roles of antimicrobial peptides and pro-inflammatory factors secreted from the cervical epithelium in Gardnerella vaginalis-abundant vaginal flora in pregnancy

Erina Matsuda, Kazuhide Takada, Osamu Kobayashi, Takahiro Nakajima, Yuji Ikeda, Mikiko Asai-Sato, Kaori Kawakami, Atsushi Komatsu, Fumihisa Chishima, Shihoko Komine-Aizawa …

Journal of Reproductive Immunology, 156 103797-103797, Jan 6, 2023 Peer-reviewedInvited
Anti-tumor effects of perampanel in malignant glioma cells

Juri Tatsuoka, Emiko Sano, Yuya Hanashima, Chihiro Yagi, Shun Yamamuro, Koichiro Sumi, Hiroyuki Hara, Kazuhide Takada, Kazunori Kanemaru, Shihoko Komine-Aizawa …

Oncology Letters, 24(6) 421, Oct 7, 2022 Peer-reviewed
TGF-β1 Promotes Zika Virus Infection in Immortalized Human First-Trimester Trophoblasts via the Smad Pathway.

Quang Duy Trinh, Ngan Thi Kim Pham, Kazuhide Takada, Chika Takano, Shihoko Komine-Aizawa, Satoshi Hayakawa

Cells, 11(19), Sep 27, 2022 Peer-reviewed
The association of three doses of the BNT162b2 mRNA vaccine with abnormal bleeding and an irregular menstrual cycle among premenopausal females: A single institute observation study

Takahiro Namiki, Shihoko Komine-Aizawa, Kazuhide Takada, Chika Takano, Quang Duy Trinh, Satoshi Hayakawa

The Journal of Obstetrics and Gynaecology Research, 48(11) 2903-2910, Sep, 2022 Peer-reviewed
Adverse events after BNT162b2 mRNA COVID-19 vaccination in health care workers and medical students in Japan

Takahiro Namiki, Shihoko Komine-Aizawa, Kazuhide Takada, Chika Takano, Quang Duy Trinh, Satoshi Hayakawa

Journal of Infection and Chemotherapy, 28(8) 1220-1224, Aug, 2022 Peer-reviewed
Restriction of SARS-CoV-2 replication in the human placenta

Kazuhide Takada, Sayaka Shimodai-Yamada, Mayumi Suzuki, Quang Duy Trinh, Chika Takano, Kaori Kawakami, Mikiko Asai-Sato, Atsushi Komatsu, Aya Okahashi, Nobuhiko Nagano …

Placenta, 127 73-76, Jul 19, 2022 Peer-reviewedLead author
Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike protein

Daichi Fujimoto, Minako Fukuya, Sachie Terao, Isao Irei, Takashi Akiyama, Anna Watanabe, Yuri Yasuda, Daisuke Yoshioka, Kazuhide Takada, Satoshi Hayakawa …

Medical Molecular Morphology, 55(4) 316-322, Jun 18, 2022 Peer-reviewed
Low Susceptibility of Rubella Virus in First-Trimester Trophoblast Cell Lines.

Ngan Thi Kim Pham, Quang Duy Trinh, Kazuhide Takada, Shihoko Komine-Aizawa, Satoshi Hayakawa

Viruses, 14(6), May 27, 2022
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus

Shingo Hayashida, Kazuhide Takada, Vyacheslav G. Melnikov, Shihoko Komine-Aizawa, Noriko M. Tsuji, Satoshi Hayakawa

Medical Hypotheses, 163 110858, Apr 18, 2022 Peer-reviewedLead authorCorresponding author
Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions.

Quang Duy Trinh, Kazuhide Takada, Ngan Thi Kim Pham, Chika Takano, Takahiro Namiki, Ryo Ikuta, Shingo Hayashida, Shoko Okitsu, Hiroshi Ushijima, Shihoko Komine-Aizawa …

Frontiers in microbiology, 13 904189-904189, 2022
Lactobacillus crispatus promotes invasion of the HTR-8/SVneo trophoblast cell line

Tomoaki Yoshida, Kazuhide Takada, Shihoko Komine-Aizawa, Yoshimasa Kamei, Osamu Ishihara, Satoshi Hayakawa

Placenta, 111 76-81, Aug, 2021 Peer-reviewedLead authorCorresponding author
S-layer protein 2 of vaginal Lactobacillus crispatus 2029 enhances growth, differentiation, VEGF production and barrier functions in intestinal epithelial cell line Caco-2

Abramov Vyacheslav M, Kosarev Igor V, Priputnevich Tatiana V, Machulin Andrey V, Abashina Tatiana N, Chikileva Irina O, Donetskova Almira D, Takada Kazuhide, Melnikov Vyacheslav G, Vasilenko Raisa N …

International Journal of Biological Macromolecules, 189 410-419, Aug, 2021 Peer-reviewed
The Epithelial-to-Mesenchymal Transition-Like Process Induced by TGF-β1 Enhances Rubella Virus Binding and Infection in A549 Cells via the Smad Pathway.

Ngan Thi Kim Pham, Quang Duy Trinh, Kazuhide Takada, Chika Takano, Mari Sasano, Shoko Okitsu, Hiroshi Ushijima, Shihoko Komine-Aizawa, Satoshi Hayakawa

Microorganisms, 9(3), Mar 23, 2021
Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan

Hayakawa S, Komine-Aizawa S, Takada K, Kimura T, Yamada H.

Journal of Obstetrics and Gynaecology Research, 47 1958-1964, Mar 23, 2021 Peer-reviewedInvited

Misc.

ARTに関わるマイクロバイオーム

髙田和秀, 竹田善紀, 相澤(小峯)志保子

日本IVF学会雑誌, 27(2) 23-27, Sep, 2024 Peer-reviewedInvitedLead authorCorresponding author
新型コロナウイルス感染症

相澤(小峯) 志保子, 髙田和秀, 早川智

臨床婦人科産科, 78(1) 86-91, Jan 10, 2024 Invited
女性生殖器の常在菌と粘膜免疫

髙田和秀, 相澤(小峯)志保子, 早川智

臨床婦人科産科, 78(1) 12-21, Jan 10, 2024 InvitedLead author
胎盤の感染のメカニズムはどこまでわかっているか

相澤(小峯)志保子, 髙田和秀, Quang Duy Trinh, 早川智

周産期医学増刊号周産期診療のための病態生理, 53 256-259, Dec 28, 2023 Invited
妊娠時の腸内細菌叢はどこまでわっているか

髙田和秀, 相澤(小峯) 志保子, 早川智

周産期医学増刊号周産期診療のための病態生理, 53 21-23, Dec 28, 2023 InvitedLead author
産科医療への影響 SARS-CoV-2感染症での胎盤の変化

髙田和秀, 相澤(小峯)志保子, 早川智

周産期医学, 53(10) 1454-1458, Oct 10, 2023 InvitedLead author
日本大学医学部資料室に収蔵される 4 点のはしか絵の解析,─本文の読み下し文に見る幕末庶民の医学思想

山本憧, 並木貴宏, 髙田和秀, 相澤(小峯) 志保子, 早川智

日大医学雑誌, 81(5) 293-298, Oct 1, 2022 Peer-reviewed
妊娠とコロナウイルス感染症

早川智, 相澤(小峯)志保子, 髙田和秀

日大医学雑誌, 80(4) 157-159, Aug 1, 2021 Peer-reviewedInvited
医学英語ライティング教育7：比較のパラグラフ

高橋良子,ジェーゴエリックハジメ, 野田直紀,飯島淳,髙田和秀,日臺智明

日大医学雑誌, 79(5) 249-253, Oct 1, 2020 Peer-reviewedInvited
医学英語ライティング教育6：パラグラフ・ライティングの推敲過程

高橋良子,野田直紀,飯島淳,髙田和秀,ジェーゴエリックハジメ, 日臺智明

日大医学雑誌, 79(4) 191-196, Aug 1, 2020 Peer-reviewedInvited
医学英語ライティング教育5：パラグラフ・ライティングによる生理学実験レポート

高橋良子,野田直紀,飯島淳,髙田和秀,日臺智明

日大医学雑誌, 79(3) 121-124, Jun 1, 2020 Peer-reviewedInvited
医学英語ライティング教育4：パラグラフ・ライティングによる微生物学実験レポート

高橋良子,髙田和秀,飯島淳,野田直紀,日臺智明

日大医学雑誌, 79(2) 59-61, Apr 1, 2020 Peer-reviewedInvited
医学英語ライティング教育3：パラグラフ・ライティングによる生物実験レポート

高橋良子,野田直紀,飯島淳,髙田和秀,日臺智明

日大医学雑誌, 79(1) 3-6, Feb 1, 2020 Peer-reviewedInvited
医学英語ライティング教育2：パラグラフ・ライティングによる化学実験レポート

高橋良子,飯島淳,野田直紀,髙田和秀,日臺智明

日大医学雑誌, 78(6) 337-340, Dec 1, 2019 Peer-reviewedInvited
医学英語ライティング教育1：パラグラフ・ライティング

高橋良子,飯島淳,野田直紀,髙田和秀,日臺智明

日大医学雑誌, 78(5) 281-284, Oct 1, 2019 Peer-reviewedInvited
Ethical issues on Genome-edited baby for prevention of vertical HIV transmission.

髙田和秀

Journal of Nihon University Medical Association, 78(4) 267-268, Aug 1, 2019 Peer-reviewedInvitedLead author
Enhanced vaginal re-epithelialization in vitro by Lactobacillus crispatus

Kazuhide Takada, Shihoko Komine-Aizawa, Quang Duy Trinh, Satoshi Hayakawa

JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124 84-84, Nov, 2017

Books and Other Publications

Reproductive Immunology 1st Edition Basic Concepts.

Takada Kazuhide, Komine-Aizawa Shihoko, Tsuji Noriko, Hayakawa Satoshi (Role: Contributor, Chapter 20: Interactions between the epithelial barrier and the microbiota in the reproductive tract.) (Original Author(s): Takada Kazuhide, Komine-Aizawa Shihoko, Tsuji Noriko, Hayakawa Satoshi)

Academic Press, Feb 26, 2021
ヒト常在菌叢と生理機能・全身疾患

髙田和秀, 早川智 (Role: Contributor, 第六章女性生殖器常在菌・感染微生物と周産期疾患) (Original Author(s): 髙田和秀、早川智)

シーエムシー出版, Aug 31, 2020

Presentations

妊娠中期SARS-CoV-2感染胎盤におけるG3BP1の胎盤バリア因子としての検証

髙田和秀, 平田雄一郎, Quang Duy Trinh, 竹田善紀, 富永大介, 辻典子, 鈴木忠樹, 山田秀人, 荒木慶彦, 相澤(小峯) 志保子, 早川智

第39回日本生殖免疫学会総会･学術集会, Dec 13, 2024
産婦人科における感染症予防の啓発―特にHPV、梅毒、COVID-19に焦点を当てて（シンポジウム2 性感染症の予防・診断・治療のUptoDate）

早川智, 相澤(小峯)志保子, 髙田和秀, 福田充

第73回日本感染症学会東日本地方会学術集会, Oct 17, 2024 Invited
子宮内細菌叢がmaternal-fetal interfaceにおける免疫寛容機序に与える影響

髙田和秀, 竹田善紀, Jonghyun Bae, Quang Duy Trinh, Dong Wook Kim, 早川智, 相澤(小峯)志保子

第52回日本臨床免疫学会総会, Oct 11, 2024
Modulation of immune tolerance at the maternal-fetal interface by endometrial microbiota

Kazuhide Takada, Yoshinori Takeda, Jonghyun Bae, Quang Duy Trinh, Dong Wook Kim, Satoshi Hayakawa, Shihoko Komine-Aizawa

Asian Congress for Reproductive Immunology 2024, Sep 7, 2024
腟内常在菌のLactbacillusは健常な腟内環境の維持に重要である

相澤(小峯)志保子, 髙田和秀, 林田真吾, 早川智

第97回日本細菌学会総会, Aug 7, 2024
妊娠中期SARS-CoV-2感染胎盤におけるG3BP1の胎盤バリア因子としての役割

髙田和秀, 平田雄一, Quang Duy Tri, 富永大介, 辻, 鈴木忠樹, 山田秀人, 荒木慶彦, 相澤(小峯)志保子, 早川智

第40回日本産婦人科感染症学会学術集会, May 26, 2024
女性生殖器における細菌叢とその役割（ワークショップ1 産婦人科における感染症学～プロからの伝承）

髙田和秀, 松田恵里那, 早川智, 川名敬, 相澤(小峯)志保子

第40回日本産婦人科感染症学会学術集会, May 25, 2024 Invited
Effects of endometrial microbiota on immune tolerance at the maternal-fetal interface

Kazuhide Takada, Jonghyun Bae, Quang Duy Trinh, Shihoko Komine-Aizawa, Dong Wook Kim, Satoshi Hayakawa

May 22, 2024
Restriction of SARS-CoV-2 replication in the human placenta

Shihoko Komine-Aizawa, Kazuhide Takada, Sayaka Shimodai-Yamada, Mayumi Suzuki, Quang Duy Trinh, Chika Takano, Tadaki Suzuki, Kei Kawana, Hideto Yamada, Satoshi Hayakawa, Hiroyuki Hao

May 20, 2024
子宮内細菌叢がmaternal-fetal interfaceにおける免疫寛容機序に与える影響の研究（学会賞候補演題）

髙田和秀, Jonghyun Bae, Quang Duy Trinh, 相澤(小峯)志保子, Dong Wook Kim, 早川智

第38回日本生殖免疫学会総会・学術集会, Nov 25, 2023
女性生殖器の常在菌と粘膜免疫（シンポジウム：ヒトの生殖と免疫）

髙田和秀

第68回日本生殖医学会学術講演会・総会, Nov 9, 2023 Invited
子宮内細菌叢がmaternal-fetal interfaceにおける免疫寛容機序に与える影響の研究

髙田和秀, Jonghyun Bae, Quang Duy Trinh, 相澤(小峯) 志保子, 早川智

第31回日本胎盤学会学術集会, Nov 4, 2023
Tandem mass tag system によるSARS-CoV-2感染胎盤のプロテオーム解析

髙田和秀, Quang Duy Trinh, 相澤(小峯)志保子, 富永大介, 辻典子, 山田秀人, 早川智

第31回日本胎盤学会学術集会, Nov 4, 2023
SARS-CoV-2感染妊婦における胎盤関門の研究 (若手研究者シンポジウム)

髙田和秀

第72回日本感染症学会東日本地方会学術集会, Oct 26, 2023 Invited
The severity of pediatric appendicitis is related to specific bacteria in the oral cavity and appendix

Ryo Ikuta, Shihoko Komine-Aizawa, Kazuhide Takada, Chika Takano, Shuichiro Uehara, Satoshi Hayakawa

36th International symposium on pediatric surgical research, Oct 7, 2023
口腔細菌は虫垂細菌叢の改変を介して小児急性虫垂炎の病態に関与する

生田稜, 髙田和秀, 高野智圭, 相澤志保子, 上原秀一郎, 早川智

第51回日本臨床免疫学会総会, Oct 6, 2023
Tandem mass tag system によるSARS-CoV-2感染における胎盤感受性影響因子の探索 (研究奨励賞候補演題)

髙田和秀, トリンズイクアン, 相澤(小峯, 志保子, 富永大介, 辻典子, 山田秀人, 早川智

第51回日本臨床免疫学会総会, Oct 6, 2023
Tandem mass tag system によるSARS-CoV-2感染胎盤のプロテオミクス解析

髙田和秀, Quang Duy Trinh, 相澤(小峯)志保子, 富永大介, 辻典子, 山田秀人, 早川智

第39回日本産婦人科感染症学会, May 20, 2023
Evaluation of protein expression and phosphorylation of SARS-CoV-2-infected placental tissue in the second trimester by tandem mass tag system.

Kazuhide Takada, Quang Duy Trinh, Shihoko Komine-Aizawa, Daisuke Tominaga, Noriko M Tsuji, Hideto Yamada, Satoshi Hayakawa

The 2nd International Symposium of Clinical Immunology, May 19, 2023
Evaluation of protein expression and phosphorylation of SARS-CoV-2-infected placental tissue in the second trimester by tandem mass tag system.

Kazuhide Takada, Quang Duy Trinh, Shihoko Komine-Aizawa, Daisuke Tominaga, Noriko M Tsuji, Hideto Yamada, Satoshi Hayakawa

Asian Congress for Reproductive Immunology 2023, Apr 9, 2023

Teaching Experience

Sep, 2024 - Present

細胞生物学 (日本大学大学院医学研究科)
Sep, 2020 - Present

実験医学序論I (日本大学大学院医学研究科)
Apr, 2020 - Present

病態生物学 (日本大学大学院医学研究科)
Apr, 2019 - Present

免疫学 (日本大学医学部)
Apr, 2019 - Present

微生物学 (日本大学医学部)
Apr, 2018 - Present

微生物学 (日本大学医学部付属看護専門学校)

Professional Memberships

Mar, 2024 - Present

The American Society for Reproductive Immunology
Aug, 2023 - Present

日本免疫学会
Dec, 2022 - Present

日本医学教育学会
Jan, 2022 - Present

日本産婦人科感染症学会
Sep, 2021 - Present

日本食品免疫学会
Jul, 2021 - Present

日本胎盤学会
Oct, 2020 - Present

日本感染症学会
Sep, 2020 - Present

日本臨床腸内微生物学会
Jul, 2017 - Present

日本生殖免疫学会
May, 2015 - Present

日本臨床免疫学会

Research Projects

Experimental study of pregnancy with periodontal disease using immune response visualization mouse

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2027
Study on mechanisms of transplacental infection of Zika virus, SARS-CoV-2, rubella virus, and possible factors affecting these virus infections in pregnancy

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2027

TRINH DUYQUANG, 早川智, 相澤志保子, 高田和秀
Analysis of COVID-19 infection in pregnant women.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
免疫細胞可視化マウスを用いた妊娠免疫応答の解明

若手研究者助成金, 日本大学, Apr, 2024 - Mar, 2025

髙田和秀
腟細菌叢による腟内恒常性維持機構の解明

科学研究費助成事業若手, Apr, 2020 - Mar, 2024

髙田和秀
子宮内細菌叢のトロホブラスト浸潤に及ぼす役割の検討

研究助成, 公益財団法人今井精一記念財団, Jan, 2022 - Dec, 2022
プロバイオティクスは腸管上皮細胞でのSARS-CoV-2感染を阻害するか？

一般研究助成, 公益財団法人ヤクルト・バイオサイエンス研究財団, Apr, 2021 - Mar, 2022

髙田和秀
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研究助成, 公益財団法人赤枝医学研究財団, Apr, 2021 - Mar, 2022

髙田和秀
ヒト胎盤におけるSARS-CoV-2複製阻害因子の探求

同窓会60周年記念医学奨励研究助成金, 日本大学医学部同窓会, Apr, 2021 - Mar, 2022

髙田和秀

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