論文

査読有り
2002年7月

Cadherin regulates dendritic spine morphogenesis

NEURON
  • H Togashi
  • ,
  • K Abe
  • ,
  • A Mizoguchi
  • ,
  • K Takaoka
  • ,
  • O Chisaka
  • ,
  • M Takeichi

35
1
開始ページ
77
終了ページ
89
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0896-6273(02)00748-1
出版者・発行元
CELL PRESS

Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spine morphology, such as filopodia-like elongation of the spine and bifurcation of its head structure, along with concomitant disruption of the distribution of postsynaptic proteins. The accumulation of synapsin at presynaptic sites and synaptic vesicle recycling were also perturbed, although these synaptic responses to the cadherin blockade became less evident upon the maturation of the synapses. These findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts.

リンク情報
DOI
https://doi.org/10.1016/S0896-6273(02)00748-1
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000176601800012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0896-6273(02)00748-1
  • ISSN : 0896-6273
  • Web of Science ID : WOS:000176601800012

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