1997年11月
Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993)
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- 巻
- 19
- 号
- 8
- 開始ページ
- 1179
- 終了ページ
- 91
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.
- リンク情報
- ID情報
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- ISSN : 1064-1963
- PubMed ID : 9385469