論文

査読有り 国際誌
2020年8月6日

Functional Roles of B-Vitamins in the Gut and Gut Microbiome.

Molecular nutrition & food research
  • Takashi Uebanso
  • ,
  • Takaaki Shimohata
  • ,
  • Kazuaki Mawatari
  • ,
  • Akira Takahashi

64
18
開始ページ
e2000426
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/mnfr.202000426

The gut microbiota produce hundreds of bioactive compounds, including B-vitamins, which play significant physiological roles in hosts by supporting the fitness of symbiotic species and suppressing the growth of competitive species. B-vitamins are also essential to the host and certain gut bacterium. Although dietary B-vitamins are mainly absorbed from the small intestine, excess B-vitamins unable to be absorbed in the small intestine are supplied to the distal gut. In addition, B-vitamins are supplied from biosynthesis by distal gut microbiota. B-vitamins in the distal colon may perform many important functions in the body; they act as (1) nutrients for a host and their microbiota, (2) regulators of immune cell activity, (3) mediators of drug efficacy, (4) supporters of survival, or the fitness of certain bacterium, (5) suppressors of colonization by pathogenic bacteria, and (6) modulators of colitis. Insights into basic biophysical principles, including the bioavailability of B-vitamins and their derivatives in the distal gut are still not fully elucidated. Here we briefly review the function of single B-vitamin in the distal gut including their roles in relation to bacteria. The prospect of extending analytical methods to better understand the role of B-vitamins in the gut is also explored. This article is protected by copyright. All rights reserved.

リンク情報
DOI
https://doi.org/10.1002/mnfr.202000426
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32761878
ID情報
  • DOI : 10.1002/mnfr.202000426
  • PubMed ID : 32761878

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