吉野孝之 (Takayuki Yoshino) - マイポータル

基本情報

所属: 国立研究開発法人国立がん研究センター東病院医薬品開発推進部門長消化管内科医長
: 岐阜大学大学院医学系研究科医科学専攻外科学講座消化器外科・小児外科学特任教授

学位: 博士（医学）(2017年7月香川大学)

J-GLOBAL ID: 201801001183144086
researchmap会員ID: B000306097

研究分野

ライフサイエンス / 腫瘍診断、治療学 /

論文

373

cfDNA-inferred putative clonal hematopoiesis during first-line platinum-to-PARP inhibitor maintenance in ovarian cancer.

Mika Okazawa-Sakai, Takao Fujisawa, Tatsuyuki Chiyoda, Hiroshi Yagi, Ichinosuke Hyodo, Shogen Boku, Yoh Hayasaki, Masanori Isobe, Daisuke Shintani, Kosei Hasegawa …

Journal of gynecologic oncology 2026年7月27日
Comprehensive Genomic and Transcriptomic Characterization of MTAP Loss Across Advanced Solid Tumors.

Kyosuke Seguchi, Takao Fujisawa, Sadakatsu Ikeda, Yu Oyama, Norio Nonomura, Chigusa Morizane, Hiroji Iwata, Susumu Okano, Hidemichi Watari, Kenjiro Namikawa …

Clinical cancer research : an official journal of the American Association for Cancer Research 2026年5月18日
Survival outcomes with matched targeted therapy in advanced biliary tract cancer: a large global cohort analysis.

Binbin Zheng-Lin, Taro Shibuki, Heidi E Kosiorek, Oluseyi Abidoye, Cody R Eslinger, Yasuyuki Kawamoto, Ryne C Ramaker, Shinji Itoh, Tadayoshi Hashimoto, Takao Fujisawa …

NPJ precision oncology 2026年5月5日
Molecular Residual Disease and Recurrence in Rectal Cancer Patients Undergoing Upfront Surgery A Prospective Cohort Study: Erratum.

Koji Ando, Atsushi Hamabe, Yoshiaki Nakamura, Jun Watanabe, Keiji Hirata, Kozo Kataoka, Masaaki Miyo, Kentaro Kato, Naoya Akazawa, Yoshinori Kagawa …

Annals of surgery 283(5) e7 2026年5月1日
Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI).

Taro Shibuki, Riu Yamashita, Tadayoshi Hashimoto, Takao Fujisawa, Mitsuho Imai, Junichiro Yuda, Takeshi Kuwata, Toshihiro Misumi, Yoshiaki Nakamura, Hideaki Bando …

International journal of clinical oncology 31(5) 843-850 2026年5月
Preoperative ctDNA and tumor volume predict colorectal cancer recurrence after metastasis resection

Hidekazu Oyoshi, Hideaki Bando, Riu Yamashita, Shun-Ichiro Kageyama, Yoshiaki Nakamura, Satoshi Horasawa, Masaki Nakamura, Takeshi Fujisawa, Kento Tomizawa, Atsushi Motegi …

npj Precision Oncology 2026年4月30日
The Q-MONSTAR consortium: advancing fault-tolerant quantum computing for precision oncology.

Mitsuho Imai, Riu Yamashita, Takao Fujisawa, Hiroki Sokuoka, Izumi Miki, Yasutoshi Sakamoto, Toshihiro Misumi, Borna Zandkarimi, Philipp T Ernst, Hideaki Bando …

Nature medicine 2026年4月21日
Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion.

Shugo Yajima, Yuichiro Tsukada, Riu Yamashita, Takao Fujisawa, Takeshi Kuwata, Reiko Watanabe, Genichiro Ishii, Nina Gabelia, Hartmut Juhl, Yoshikatsu Koga …

Cancer medicine 15(4) e71843 2026年4月
Psychological distress and cancer worry in unaffected relatives undergoing cascade testing with multigene panel testing.

Kaori Kimura, Takeshi Kuwata, Yumie Hiraoka, Manami Matsukawa, Chikako Tomozawa, Miki Aitani, Yu Komura, Izumi Miki, Masashi Wakabayashi, Yosuke Furui …

Journal of human genetics 2026年3月2日
Prognostic Biomarkers and Immunotherapeutic Insights of Circulating Tumor DNA Analysis in Advanced Esophageal Squamous Cell Carcinoma From SCRUM-MONSTAR GOZILA Substudy.

Yuqing Duan, Tadayoshi Hashimoto, Taro Shibuki, Hiroya Taniguchi, Yu Sunakawa, Yoshito Komatsu, Naoki Takahashi, Yuta Sato, Kensei Yamaguchi, Tomohiro Nishina …

JCO precision oncology 10(3) e2500971 2026年3月
Survival outcomes of ERBB2-amplified metastatic colorectal cancer treated with first-line chemotherapy.

Yuki Matsubara, Hideaki Bando, Yoshiaki Nakamura, Toshihiro Misumi, Dionne Ng, Eri Tajima, Harlan Pittell, Atsushi Ohtsu, Takayuki Yoshino

British journal of cancer 134(3) 463-468 2026年2月
Genomic landscape of immune checkpoint inhibitor-induced aplastic anemia: a case report.

Nobuyuki Takahashi, Kenichi Harano, Chikako Funasaka, Hiromichi Nakajima, Chihiro Kondoh, Nobuaki Matsubara, Ako Hosono, Yoichi Naito, Michiko Nagamine, Hiroshi Tanabe …

Frontiers in oncology 16 1801452-1801452 2026年
Prognostic stratification of recurrent colorectal liver metastasis: impact of recurrence-free interval, tumor numbers, and size on repeat liver resection

Hajime Kamiya, Shin Kobayashi, Masashi Kudo, Motokazu Sugimoto, Akihito Kawazoe, Hideaki Bando, Yuichiro Tsukada, Masaaki Ito, Takayuki Yoshino, Naoto Gotohda

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 31(1) 128-140 2026年1月
HER2 Protein Overexpression, mRNA Expression, and DNA Amplification Across Solid Tumors: Comparison of Next-Generation Sequencing-Based Assays With Immunohistochemistry.

Michiko Nagamine, Takao Fujisawa, Naoya Sakamoto, Yoshiaki Nakamura, Shigenori Kadowaki, Makoto Ueno, Shogen Boku, Yoshito Komatsu, Eiji Oki, Akitaka Makiyama …

JCO precision oncology 10 e2500413 2026年1月
Genomic alteration and clinical significance of circulating tumor DNA in patients with advanced urothelial cancer: SCRUM-Japan monstar screen project.

Takahiro Osawa, Nobuaki Matsubara, Taigo Kato, Masaki Shiota, Koshiro Nishimoto, Takashige Abe, Nobuo Shinohara, Yota Yasumizu, Nobuyuki Tanaka, Mototsugu Oya …

NPJ precision oncology 9(1) 362-362 2025年11月18日
Chronological survival improvement over time with oxaliplatin-based chemotherapy plus targeted agents in metastatic colorectal cancer: An ARCAD database study.

Kazumasa Yamamoto, Hideaki Bando, Toshihiro Misumi, Tomomi Nishikawa, Masashi Wakabayashi, Kentaro Yamazaki, Yoshihiko Maehara, Eiji Oki, Leonard B Saltz, Jean-Yves Douillard …

European journal of cancer (Oxford, England : 1990) 230 116034-116034 2025年11月17日
A multicenter phase II study of eribulin for BRAF V600E mutant metastatic colorectal cancer: the BRAVERY study (EPOC1701).

T Masuishi, H Taniguchi, D Kotani, H Bando, Y Komatsu, E Shinozaki, Y Sunakawa, T Satoh, T Nishina, T Esaki …

ESMO open 10(11) 105839-105839 2025年10月9日
Resistance mechanism to pembrolizumab in DEK-AFF2 fusion-associated sinonasal squamous cell carcinoma

Shogen Boku, Takao Fujisawa, Shigenori Kadowaki, Hironaga Satake, Hisateru Yasui, Koushiro Ohtsubo, Yasushi Shimizu, Tomoyuki Otsuka, Bunya Kuze, Riu Yamashita …

INTERNATIONAL CANCER CONFERENCE JOURNAL 14(4) 458-463 2025年10月
Resistance mechanism to pembrolizumab in DEK-AFF2 fusion-associated sinonasal squamous cell carcinoma.

Shogen Boku, Takao Fujisawa, Shigenori Kadowaki, Hironaga Satake, Hisateru Yasui, Koushiro Ohtsubo, Yasushi Shimizu, Tomoyuki Otsuka, Bunya Kuze, Riu Yamashita …

International cancer conference journal 14(4) 458-463 2025年10月
Risk Model for Lymph Node-Positive Prostate Cancer After Radical Prostatectomy.

Kojiro Tashiro, Keiichiro Mori, Masaki Shiota, Wataru Fukuokaya, Dai Takamatsu, Yoshiyuki Matsui, Masashi Kato, Ryoichi Saito, Akira Yokomizo, Masakazu Tsutsumi …

International journal of urology : official journal of the Japanese Urological Association 32(10) 1386-1392 2025年10月

もっとみる

MISC

The MONSTAR-SCREEN-3 Spatial Atlas: Pan-cancer TME archetypes and clinically relevant tumor-immune ecosystems

Mitsuho Imai, Eun Seop Seo, Jiyeon Hyeon, Shingo Sakashita, Yuka Nakamura, Tadayoshi Hashimoto, Shin Kobayashi, Jun Yuda, Riu Yamashita, Taro Shibuki …

CANCER RESEARCH 86(7) 2026年4月3日
Impact of postoperative ctDNA dynamics on eligibility for the ALTAIR randomized trial in patients with colorectal cancer: Implications for clinical trial enrollment.

Yoshiaki Nakamura, Hideaki Bando, Vasily N. Aushev, Jun Watanabe, Yusuke Takahashi, Masahito Kotaka, Nobuhisa Matsuhashi, Eiji Oki, Yoshito Komatsu, Manabu Shiozawa …

JOURNAL OF CLINICAL ONCOLOGY 44(2_SUPPL) 12-12 2026年1月
Prognostic value of presurgical circulating tumor DNA (ctDNA) levels and other clinical factors in colon cancer.

Naoya Akazawa, Saori Mishima, Koji Ando, Daisuke Kotani, Yoshiaki Nakamura, Hideaki Bando, Hiroya Taniguchi, Jun Watanabe, Takeshi Kato, Yusuke Suwa …

JOURNAL OF CLINICAL ONCOLOGY 44(2_SUPPL) 221-221 2026年1月
Assessing adjuvant chemotherapy benefit in younger and older molecular residual disease-positive patients with stage II/III colorectal cancer

Saori Mishima, Koji Ando, Daisuke Kotani, Yoshiaki Nakamura, Hideaki Bando, Hiroya Taniguchi, Jun Watanabe, Takeshi Kato, Yusuke Suwa, Naoya Akazawa …

JOURNAL OF CLINICAL ONCOLOGY 44(2_SUPPL) 216-216 2026年1月
Post-hoc central radiological review of the ALTAIR study in patients with molecular residual disease (MRD) following curative resection of colorectal cancer (CRC).

Jun Watanabe, Hideaki Bando, Masahito Kotaka, Nobuhisa Matsuhashi, Eiji Oki, Yoshito Komatsu, Manabu Shiozawa, Keiji Hirata, Yuji Miyamoto, Kun-Huei Yeh …

JOURNAL OF CLINICAL ONCOLOGY 44(2_SUPPL) 138-138 2026年1月
Identification of Predictive Biomarkers for the Efficacy of Immune Checkpoint Inhibitors through Multi-Omics Analysis

Taigo Kato, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Koji Hatano, Atsunari Kawashima, Kazuma Kiyotani, Takao Fujisawa, Hideaki Bando, Yoshiaki Nakamura …

CANCER SCIENCE 117 826-826 2026年1月
Molecular residual disease detection using whole-genome sequencing-based ctDNA assay for resectable colorectal cancer in the MONSTAR-SCREEN-3 project.

Yoshinori Kagawa, Yuichiro Tsukada, Masahito Kotaka, Yusuke Suwa, Nobuhisa Matsuhashi, Takeshi Kato, Yasuki Akiyama, Mamoru Uemura, Koji Ando, Akiyoshi Kanazawa …

JOURNAL OF CLINICAL ONCOLOGY 44(2_SUPPL) 187-187 2026年1月
Niraparib plus PD-1 inhibitor for patients previously treated with immune checkpoint inhibitor for solid tumors with homologous recombination repair gene mutation (IMAGENE): A phase II basket study.

Taigo Kato, Takahiro Kojima, Masaki Shiota, Masashi Nakayama, Nobuaki Matsubara, Kenjiro Namikawa, Takahiro Osawa, Takashige Abe, Yota Yasumizu, Nobuyuki Tanaka …

JOURNAL OF CLINICAL ONCOLOGY 43(16_SUPPL) 2025年6月1日
Clinical significance of the CGRP pathway gene expression in advanced solid tumors: A sub-analysis of MONSTAR-SCREEN-2.

Takao Fujisawa, Naoya Sakamoto, Yoshiaki Nakamura, Riu Yamashita, Takeshi Kuwata, Michiko Nagamine, Genichiro Ishii, Chigusa Morizane, Norio Nonomura, Hiroji Iwata …

JOURNAL OF CLINICAL ONCOLOGY 43(16_SUPPL) 2025年6月1日
A randomized, double-blind, phase III study comparing trifluridine/tipiracil (FTD/TPI) versus placebo in patients with molecular residual disease following curative resection of colorectal cancer (CRC): The ALTAIR Study Free

Hideaki Bando, Jun Watanabe, Masahito Kotaka, Nobuhisa Matsuhashi, Eiji Oki, Yoshito Komatsu, Manabu Shiozawa, Keiji Hirata, Yuji Miyamoto, Kun-Huei Yeh …

CANCER RESEARCH 85(8) 2025年4月15日
A randomized, double-blind, phase III study comparing trifluridine/tipiracil (FTD/TPI) versus placebo in patients with molecular residual disease following curative resection of colorectal cancer (CRC): The ALTAIR study.

Hideaki Bando, Jun Watanabe, Masahito Kotaka, Nobuhisa Matsuhashi, Eiji Oki, Yoshito Komatsu, Manabu Shiozawa, Keiji Hirata, Yuji Miyamoto, Kun-Huei Yeh …

JOURNAL OF CLINICAL ONCOLOGY 43(4_SUPPL) LBA22-LBA22 2025年2月
ctDNAによる局所進行直腸癌に対するTNTの効果予測

三代雅明, 賀川義規, 渡邉純, 植村守, 安藤幸滋, 井上彬, 諏訪雄亮, 波多豪, 大庭幸治, Laliotis George …

日本癌治療学会学術集会抄録集 62回 PS-5 2024年10月
Correlation of enriched specific subset of immune cells nearby tumor associated macrophage (TAM) with pathologic complete response (pCR) of concurrent chemoradiotherapy followed by nivolumab in locally advanced rectal cancer (LARC).

Hideaki Bando, Yuichiro Tsukada, Koji Inamori, Takeshi Kato, Yoshito Komatsu, Mamoru Uemura, Satoshi Yuki, Akinobu Taketomi, Takao Fujisawa, Yoshiaki Nakamura …

JOURNAL OF CLINICAL ONCOLOGY 42(23_SUPPL) 58-58 2024年8月10日
Observational study examining the feasibility of generating real-world evidence (RWE) for new drug applications from the clinical trials database (DB; RELIASE study).

Hideaki Bando, Toshihiro Misumi, Yasutoshi Sakamoto, Yuriko Takeda, Yoshiaki Nakamura, Kazuya Mizuguchi, Yoshihiro Aoyagi, Izumi Miki, Takayuki Yoshino, Atsushi Ohtsu

JOURNAL OF CLINICAL ONCOLOGY 42(23_SUPPL) TPS100-TPS100 2024年8月10日
Prognostic and predictive value of ctDNA-based MRD and actionable biomarkers in patients with resectable colorectal cancer: CIRCULATE-Japan GALAXY.

Yoshiaki Nakamura, Jun Wantanabe, Keiji Hirata, Naoya Akazawa, Kozo Kataoka, Mitsuru Yokota, Kentaro Yamazaki, Kentaro Kato, Masahito Kotaka, Yoshinori Kagawa …

JOURNAL OF CLINICAL ONCOLOGY 42(16) 2024年6月1日
ARCAD Gastricについて

寺島雅典, 設楽紘平, 沖英次, 大庭幸治, 川添彬人, 中山厳馬, 徳永正則, 神田光郎, 三角俊裕, 掛地吉弘 …

日本外科学会定期学術集会抄録集 124回 SP-3 2024年4月
Circulating tumor DNA (ctDNA) dynamics in patients with colorectal cancer (CRC) with molecular residual disease: Updated analysis from GALAXY study in the CIRCULATE-JAPAN.

Hiroki Yukami, Yoshiaki Nakamura, Saori Mishima, Koji Ando, Hideaki Bando, Jun Watanabe, Keiji Hirata, Naoya Akazawa, Masataka Ikeda, Mitsuru Yokota …

JOURNAL OF CLINICAL ONCOLOGY 42(3_SUPPL) 6-6 2024年1月20日
Neoadjuvant anti-programmed death 1 (PD-1) therapy in patients (pts) with resectable mismatch repair-deficient (dMMR) locally advanced rectal cancer (LARC): EPOC2201.

Hideaki Bando, Yuichiro Tsukada, Akinobu Taketomi, Satoshi Yuki, Yoshito Komatsu, Takashi Akiyoshi, Eiji Shinozaki, Yukihide Kanemitsu, Atsuo Takashima, Manabu Shiozawa …

JOURNAL OF CLINICAL ONCOLOGY 42(3_SUPPL) TPS226-TPS226 2024年1月20日
Multiomic analysis for minimal residual disease detection: Addressing challenges in stage II-III colon cancer from COSMOS-CRC-01

Yoshiaki Nakamura, Yuichiro Tsukada, Nobuhisa Matsuhashi, Tatsuro Murano, Manabu Shiozawa, Takeshi Kato, Eiji Oki, Masahiro Goto, Yoshinori Kagawa, Akiyoshi Kanazawa …

JOURNAL OF CLINICAL ONCOLOGY 42(3_SUPPL) 180-180 2024年1月20日
Real-world clinical efficacy of epidermal growth factor receptor inhibitors (EGFRi) in patients with early-onset (eo), metastatic colorectal cancer (mCRC).

Hideaki Bando, Toshihiro Misumi, Harlan Pittell, Dionne Ng, Eri Tajima, Trevor Joseph Royce, Ivy Altomare, Prashni Paliwal, Yoshihiro Aoyagi, Kazuya Mizuguchi …

JOURNAL OF CLINICAL ONCOLOGY 42(3_SUPPL) 36-36 2024年1月20日

もっとみる

共同研究・競争的資金等の研究課題

肝癌微小環境におけるフェロトーシス抵抗性の機序解明と治療への展開

日本学術振興会科学研究費助成事業基盤研究(B) 2026年4月 - 2029年3月

伊藤心二, 奥崎大介, 小玉尚宏, 吉野孝之, 大谷直子, 山田健一, 吉住朋晴
直腸癌の個別的リスク評価を目的とした人工知能MRI解析アルゴリズムの確立

日本学術振興会科学研究費助成事業基盤研究(B) 2022年4月 - 2025年3月

竹政伊知朗, 渡邊昌彦, 内藤剛, 浜部敦史, 奥谷浩一, 石井雅之, 畠中正光, 森正樹, 土岐祐一郎, 江口英利, 坂井義治, 肥田侯矢, 吉野孝之, 沖英次