Kensaku Murano

Profile Information

Affiliation: School of Medicine, Keio University

J-GLOBAL ID: 201801009943369114
researchmap Member ID: B000314879

External link: http://siomilab.med.keio.ac.jp

Research Interests

Research Areas

Life sciences / Molecular biology /

Papers

Transcription of MERVL retrotransposons is required for preimplantation embryo development

Akihiko Sakashita, Tomohiro Kitano, Hirotsugu Ishizu, Youjia Guo, Harumi Masuda, Masaru Ariura, Kensaku Murano, Haruhiko Siomi

Nature Genetics, Mar 2, 2023
Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant.

Setsuko Mise-Omata, Mari Ikeda, Masaru Takeshita, Yoshifumi Uwamino, Masatoshi Wakui, Tomoko Arai, Ayumi Yoshifuji, Kensaku Murano, Haruhiko Siomi, Kensuke Nakagawara …

Journal of immunology (Baltimore, Md. : 1950), 209(11) 2104-2113, Dec 1, 2022
TDP-43 safeguards the embryo genome from L1 retrotransposition.

Ten D Li, Kensaku Murano, Tomohiro Kitano, Youjia Guo, Lumi Negishi, Haruhiko Siomi

Science advances, 8(47) eabq3806, Nov 25, 2022
Generation of Stable Drosophila Ovarian Somatic Cell Lines Using the piggyBac System

Chikara Takeuchi, Kensaku Murano, Mitsuru Ishikawa, Hideyuki Okano, Yuka W. Iwasaki

Methods in Molecular Biology, 143-153, 2022
The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

Kensaku Murano, Youjia Guo, Haruhiko Siomi

Biochemical Society Transactions, 49(6) 2879-2890, Dec 17, 2021
Potent mouse monoclonal antibodies that block SARS-CoV-2 infection.

Youjia Guo, Atsushi Kawaguchi, Masaru Takeshita, Takeshi Sekiya, Mikako Hirohama, Akio Yamashita, Haruhiko Siomi, Kensaku Murano

The Journal of biological chemistry, 100346-100346, Jan 29, 2021
Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.

Ryo Onishi, Kaoru Sato, Kensaku Murano, Lumi Negishi, Haruhiko Siomi, Mikiko C Siomi

Science advances, 6(50), Dec, 2020
Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.

Ken Osumi, Kaoru Sato, Kensaku Murano, Haruhiko Siomi, Mikiko C Siomi

EMBO reports, 20(12) e48296, Dec 5, 2019 Peer-reviewed
Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming.

Phuong Linh Bui, Ken Nishimura, Gonzalo Seminario Mondejar, Arun Kumar, Shiho Aizawa, Kensaku Murano, Kyosuke Nagata, Yohei Hayashi, Aya Fukuda, Yasuko Onuma …

Cell reports, 29(7) 1909-1922, Nov 12, 2019 Peer-reviewed
Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.

Kensaku Murano, Yuka W Iwasaki, Hirotsugu Ishizu, Akane Mashiko, Aoi Shibuya, Shu Kondo, Shungo Adachi, Saori Suzuki, Kuniaki Saito, Tohru Natsume …

The EMBO journal, 38(17) e102870, Sep 2, 2019 Peer-reviewed
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.

Taketaro Sadahiro, Mari Isomi, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Fumiya Tamura, Hidenori Tani, Shugo Tohyama, Jun Fujita …

Cell stem cell, 23(3) 382-395, Sep 6, 2018 Peer-reviewed
Profiling Open Chromatin Structure in the Ovarian Somatic Cells Using ATAC-seq.

Kensaku Murano, Yuka W Iwasaki, Haruhiko Siomi

Methods in molecular biology (Clifton, N.J.), 1680 165-177, 2018 Peer-reviewed
Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity

Takeshi Sekiya, Kensaku Murano, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata

FEBS OPEN BIO, 7(3) 397-404, Mar, 2017 Peer-reviewed
Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons

Yuka W. Iwasaki, Kensaku Murano, Hirotsugu Ishizu, Aoi Shibuya, Yumiko Iyoda, Mikiko C. Siomi, Haruhiko Siomi, Kuniaki Saito

MOLECULAR CELL, 63(3) 408-419, Aug, 2016 Peer-reviewed
Oseltamivir Expands Quasispecies of Influenza Virus through Cell-to-cell Transmission

Kotaro Mori, Kensaku Murano, Ryosuke L. Ohniwa, Atsushi Kawaguchi, Kyosuke Nagata

SCIENTIFIC REPORTS, 5 9163, Mar, 2015 Peer-reviewed
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex

Kensaku Murano, Mitsuru Okuwaki, Fumitaka Momose, Michiko Kumakura, Shuhei Ueshima, Robert F. Newbold, Kyosuke Nagata

JOURNAL OF CELL SCIENCE, 127(15) 3309-3319, Aug, 2014 Peer-reviewed
Regulation of Nucleolar Chromatin by B23/Nucleophosmin Jointly Depends upon Its RNA Binding Activity and Transcription Factor UBF

Miharu Hisaoka, Shuhei Ueshima, Kensaku Murano, Kyosuke Nagata, Mitsuru Okuwaki

MOLECULAR AND CELLULAR BIOLOGY, 30(20) 4952-4964, Oct, 2010 Peer-reviewed
Regulation of Nucleolar Chromatin by B23/Nucleophosmin Jointly Depends upon Its RNA Binding Activity and Transcription Factor UBF

Miharu Hisaoka, Shuhei Ueshima, Kensaku Murano, Kyosuke Nagata, Mitsuru Okuwaki

Molecular and Cellular Biology, 30(20) 4952-4964, Oct, 2010 Peer-reviewed
Sp1-mediated transcription regulation of TAF-I alpha gene encoding a histone chaperone

Masamitsu N. Asaka, Kensaku Murano, Kyosuke Nagata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(4) 665-670, Nov, 2008 Peer-reviewed
Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity

Kensaku Murano, Mitsuru Okuwaki, Miharu Hisaoka, Kyosuke Nagata

MOLECULAR AND CELLULAR BIOLOGY, 28(10) 3114-3126, May, 2008 Peer-reviewed

Misc.

PiwiはMaelstromを介してBrm依存的なトランスポゾンを抑制する

大西遼, 佐藤薫, 村野健作, 根岸瑠美, 塩見春彦, 塩見美喜子

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
SARS-CoV-2感染を阻害する強力なマウスモノクローナル抗体

村野健作, GUO Youjia, 川口敦史, 竹下勝, 山下暁朗, 塩見春彦

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
piRNAを介したトランスポゾン転写抑制機構におけるMaelとBrmの機能

大西遼, 佐藤薫, 村野健作, 高橋亜紀子, 根岸瑠美, 塩見春彦, 塩見美喜子

日本RNA学会年会要旨集, 21st, 2019
転写因子Sp1によるサイレンと遺伝子の活性化

浅賀正充N, 村野健作, 加藤広介, 永田恭介

生化学, 2007
Functional specificity of histone chaperones

Kyosuke Nagata, Kensaku Murano, Kohsuke Kato, Mitsuru Okuwaki

GENES & GENETIC SYSTEMS, 81(6) 456-456, Dec, 2006
ヒストンシャペロン活性を持つTAF-Iの活性型ごとの遺伝子発現レベルにおける個別調節

浅賀正充, 村野健作, 永田恭介

日本分子生物学会年会プログラム・講演要旨集, 27th, 2004
細胞増殖過程におけるTAF-Iの発現調節機構の解析

浅賀正充, 村野健作, 永田恭介

日本分子生物学会年会プログラム・講演要旨集, 26th, 2003

Professional Memberships

Research Projects

転移因子の転写と共役した細胞核構造の組織化

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2027

村野健作
小分子RNAによるトランスポゾン転写抑制機構の解析

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

村野健作
Role of retrotransposons in early embryonic development and totipotency control

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

MURANO Kensaku
Maintenance of the germ cell genome by non-coding RNA

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

MURANO Kensaku
Molecular pathways leading to epigenome formation in mammalian germ cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2013 - Mar, 2018

SIOMI HARUHIKO, HASUWA Hidetoshi, IWASAKI Yuka, YAMANAKA Soichiro, MURANO Kensaku
新規高感度レポーター系を用いたrRNA遺伝子の種特異的転写開始機構の解析

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Jun, 2013 - Mar, 2015

村野健作
Dynamics of sperm chromatin

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

MURANO Kensaku, NAGATA Kyosuke
ヒストンシャペロンTAF-Iによる初期胚細胞核ダイナミクスの制御機構

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2011 - 2012

村野健作, 加藤広介
発生分化過程におけるヒストンシャペロンTAF-lの機能

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2009 - 2010

村野健作

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