2019年11月4日
Rational Design of a Dual-Reactivity-Based Fluorescent Probe for Visualizing Intracellular HSNO.
Angewandte Chemie (International ed. in English)
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- 巻
- 58
- 号
- 45
- 開始ページ
- 16067
- 終了ページ
- 16070
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/anie.201908950
- 出版者・発行元
- Wiley
Thionitrous acid (HSNO), the smallest S-nitrosothiol, is emerging as a potential key intermediate in cellular redox regulation linking two signaling molecules H2 S and NO. However, the chemical biology of HSNO remains poorly understood. A major hurdle is the lack of methods for selective detection of HSNO in biological systems. Herein, we report the rational design, synthesis, and evaluation of the first fluorescent probe TAP-1 for HSNO detection. TAP-1 showed high selectivity and sensitivity to HSNO in aqueous media and cells, providing a useful tool for understanding the functions of HSNO in biology.
- リンク情報
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- DOI
- https://doi.org/10.1002/anie.201908950
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31479578
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814498
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073921106&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85073921106&origin=inward
- URL
- http://orcid.org/0000-0002-0623-1710
- ID情報
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- DOI : 10.1002/anie.201908950
- ISSN : 1433-7851
- eISSN : 1521-3773
- ORCIDのPut Code : 62078907
- PubMed ID : 31479578
- PubMed Central 記事ID : PMC6814498
- SCOPUS ID : 85073921106