Akira Futatsugi

Profile Information

Affiliation: Kobe City College of Nursing
: 非常勤講師, 甲南女子大学

Degree: 医学博士(東京大学)

J-GLOBAL ID: 201501000501563516
researchmap Member ID: B000248272

External link: http://www.kobe-ccn.ac.jp/

兵庫県神戸市出身。これまでの主な研究領域は、カルシウムチャンネルの生理機能、神経細胞死のメカニズム、細胞の増殖と分化の制御、等。

Research Interests

Research Areas

Research History

Apr, 2015 - Present

Kobe City College of Nursing
Apr, 2011 - Present

Faculty of Nursing and Rehabilitation, Konan Women's University
Apr, 2016 - Sep, 2018

Kwansei Gakuin University
Apr, 2010 - Mar, 2015

Kobe City College of Nursing
Aug, 2007 - Feb, 2010

博士研究員, Functional Genomics Section, NIDCR, 米国国立衛生研究所 (NIH)
Jun, 2006 - Jul, 2007

Juntendo University
Apr, 2001 - Dec, 2005

研究員, カルシウム振動プロジェクト, 科学技術振興機構 ICORP
Oct, 2000 - Mar, 2001

研究員, 発生神経生物研究チーム, 理化学研究所脳科学総合研究センター
Nov, 1998 - Sep, 2000

研究員（グループリーダー代行）, 御子柴細胞制御プロジェクト, 科学技術振興事業団 ERATO
Nov, 1998 - Jul, 1999

訪問研究員, 分子神経生物研究チーム, 理化学研究所筑波ライフサイエンスセンター
Apr, 1991 - Oct, 1998

研究員, 医科学研究所, 塩野義製薬（株）
Apr, 1995 - Jul, 1995

Institute for Virus Research, Kyoto University

Education

Jun, 2006 - Jun, 2006

The University of Tokyo
Feb, 2006 - May, 2006

Faculty of Medicine, Juntendo University
Apr, 1996 - Mar, 1998

The Institute of Medical Science, The University of Tokyo
Apr, 1989 - Mar, 1991

化学工学専攻修士課程, 工学系研究科, 東京大学大学院
Apr, 1987 - Mar, 1989

The Faculty of Engineering, The University of Tokyo
Apr, 1985 - Mar, 1987

College of Arts and Sciences, The University of Tokyo

Papers

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function.

Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki …

iScience, 24(7) 102758-102758, Jul 23, 2021 Peer-reviewed
Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour.

Anikó Kárpáti, Takeo Yoshikawa, Fumito Naganuma, Takuro Matsuzawa, Haruna Kitano, Yo Yamada, Mariko Yokoyama, Akira Futatsugi, Katsuhiko Mikoshiba, Kazuhiko Yanai

Scientific reports, 9(1) 16451-16451, Nov 11, 2019 Peer-reviewed
RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.

Kei Nakayama, Rie Ohashi, Yo Shinoda, Maya Yamazaki, Manabu Abe, Akihiro Fujikawa, Shuji Shigenobu, Akira Futatsugi, Masaharu Noda, Katsuhiko Mikoshiba …

eLife, 6, Nov 21, 2017 Peer-reviewed
終末期ケアを受けるがん患者におけるアロマセラピーマッサージの有効性

相原由花, 二木啓, 江川幸二, 鈴木志津枝

日本統合医療学会誌, 9(1) 85-92, May, 2016 Peer-reviewed
ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

Ryuji Oshima, Takafumi Hasegawa, Keiichi Tamai, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Akio Kikuchi, Toru Baba, Akira Futatsugi, Ikuro Sato …

SCIENTIFIC REPORTS, 6 24997, Apr, 2016 Peer-reviewed
正期産における前期破水と日常生活行動との関係より安全で自然な分娩をめざして

原千夏, 阿部久美子, 吉田晶葉, 宮田和美, 藤井ひろみ, 奥山葉子, 有本梨花, 嶋澤恭子, 高田昌代, 二木啓 …

兵庫県母性衛生学会雑誌, (22) 24-29, Dec, 2013 Peer-reviewed
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons

Akira Futatsugi, Elias Utreras, Parvathi Rudrabhatla, Howard Jaffe, Harish C. Pant, Ashok B. Kulkarni

CELL CYCLE, 11(8) 1603-1610, Apr, 2012 Peer-reviewed
Knockdown of Ca(v)2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice

Hiromitsu Saito, Motohiro Okada, Takafumi Miki, Minoru Wakamori, Akira Futatsugi, Yasuo Mori, Katsuhiko Mikoshiba, Noboru Suzuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 390(3) 1029-1033, Dec, 2009 Peer-reviewed
Tumor Necrosis Factor-alpha Regulates Cyclin-dependent Kinase 5 Activity during Pain Signaling through Transcriptional Activation of p35

Elias Utreras, Akira Futatsugi, Parvathi Rudrabhatla, Jason Keller, Michael J. Iadarola, Harish C. Pant, Ashok B. Kulkarni

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(4) 2275-2284, Jan, 2009 Peer-reviewed
Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum

Akira Futatsugi, Etsuko Ebisui, Katsuhiko Mikoshiba

JOURNAL OF NEUROCHEMISTRY, 105(4) 1153-1164, May, 2008 Peer-reviewed
Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells

Akihiro Mizutani, Yukiko Kuroda, Akira Futatsugi, Teiichi Furuichi, Katsuhiko Mikoshiba

JOURNAL OF NEUROSCIENCE, 28(20) 5369-5382, May, 2008 Peer-reviewed
Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3

N Ooashi, A Futatsugi, F Yoshihara, K Mikoshiba, H Kamiguchi

JOURNAL OF CELL BIOLOGY, 170(7) 1159-1167, Sep, 2005 Peer-reviewed
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism

A Futatsugi, T Nakamura, MK Yamada, E Ebisui, K Nakamura, K Uchida, T Kitaguchi, H Takahashi-Iwanaga, T Noda, J Aruga …

SCIENCE, 309(5744) 2232-2234, Sep, 2005 Peer-reviewed
小脳プルキンエ細胞シナプスに及ぼすP/Q-typeカルシウムチャネルノックアウトの影響(Effects of the P/Q-type Ca channel knockout on the cerebellar Purkinje cell synapse)

Kuruma Akinori, Inoue Takafumi, Goto Jun-ichi, Futatsugi Akira, Mikoshiba Katsuhiko

Neuroscience Research, 52(Suppl.) S75-S75, Jul, 2005 Peer-reviewed
小脳プルキンエ細胞シナプスに及ぼすP/QタイプCaチャネルノックアウトの影響(Effects of the P/Q-type Ca channel knockout on the cerebellar Purkinje cell synapses)

Kuruma Akinori, Inoue Takafumi, Goto Jun-ichi, Futatsugi Akira, Mikoshiba Katsuhiko

The Japanese Journal of Physiology, 55(Suppl.) S148-S148, May, 2005 Peer-reviewed
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant

M Iwai, Y Tateishi, M Hattori, A Mizutani, T Nakamura, A Futatsugi, T Inoue, T Furuichi, T Michikawa, K Mikoshiba

JOURNAL OF BIOLOGICAL CHEMISTRY, 280(11) 10305-10317, Mar, 2005 Peer-reviewed
新規2型イノシトール3リン酸受容体スプライシングアイソフォームの受容体細胞内局在における役割(A novel mouse type-2 IP3 receptor variant functions as a negative coordinator of receptor clustering)

Iwai Miwako, Tateishi Yoko, Hattori Mitsuharu, Mizutani Akihiro, Futatsugi Akira, Inoue Takafumi, Furuichi Teiichi, Michikawa Takayuki, Mikoshiba Katsuhiko

生化学, 76(8) 888-888, Aug, 2004 Peer-reviewed
M-3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice

T Nakamura, M Matsui, K Uchida, A Futatsugi, S Kusakawa, N Matsumoto, K Nakamura, T Manabe, MM Taketo, K Mikoshiba

JOURNAL OF PHYSIOLOGY-LONDON, 558(2) 561-575, Jul, 2004 Peer-reviewed
Immunocytochemical localization of the alpha(1A) subunit of the P/Q-type calcium channel in the rat cerebellum

A Kulik, K Nakadate, A Hagiwara, Y Fukazawa, R Lujan, H Saito, N Suzuki, A Futatsugi, K Mikoshiba, M Frotscher …

EUROPEAN JOURNAL OF NEUROSCIENCE, 19(8) 2169-2178, Apr, 2004 Peer-reviewed
Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3

A Futatsugi, K Kato, H Ogura, ST Li, E Nagata, G Kuwajima, K Tanaka, S Itohara, K Mikoshiba

NEURON, 24(3) 701-713, Nov, 1999

Misc.

Degitalization of Anatomical Models of the Human Body by 3D Laser Scanner

渡辺定博, 片山修, 二木啓, 藤井ひろみ, 石原逸子

神戸市看護大学紀要, 22 1-7, Mar, 2018
RNA顆粒構成因子RNG105は、シナプス後部形態の可塑的変化を制御し、記憶形成に必要である

中山啓, 阿部学, 山崎真弥, 藤川顕寛, 野田昌晴, 二木啓, 御子柴克彦, 崎村建司, 椎名伸之

生命科学系学会合同年次大会, 2017年度 [1P-1301], Dec, 2017
トリクロサン(抗菌剤)の肝細胞毒性発現に対するDimethyl sulfoxide(DMSO)との相乗効果

丹野恵一, 二木啓, 片山修, 清水透

神戸市看護大学紀要, 21 103-103, Mar, 2017
3Dスキャナーによる人体模型のデジタル化

渡辺定博, 片山修, 石原逸子, 二木啓, 藤井ひろみ

形態・機能, 14(1) 43-43, Sep, 2015
Cyclin dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons

A. Futatsugi, E. Utreras, P. Rudrabhatla, H. Jaffe, H. C. Pant, A. B. Kulkarni

JOURNAL OF NEUROCHEMISTRY, 123 114-114, Oct, 2012
がん患者の緩和ケアにおけるアロママッサージの有効性

相原由花, 江川幸二, 二木啓, 鈴木志津枝

日本緩和医療学会学術大会プログラム・抄録集, 17回 314-314, Jun, 2012
骨格筋におけるパールカンの役割の検討

許卓, 二木啓, 市川直樹, 黒澤尚, 平澤恵理

順天堂医学, 55(3) 387-388, Sep, 2009
Molecular Roles of Cdk5 in Pain Signaling.

Utreras E, Futatsugi A, Pareek TK, Kulkarni AB

Drug discovery today. Therapeutic strategies, 6(3) 105-111, Sep, 2009 Peer-reviewed
骨格筋におけるパールカンの役割の検討

許卓, 二木啓, 市川直樹, 黒澤尚, 平澤恵理

順天堂医学, 54(3) 416-416, Sep, 2008
The role of Ca2+ signaling in cell function with special reference to exocrine secretion

Katsuhiko Mikoshiba, Chihiro Hisatsune, Akira Futatsugi, Akihiro Mizutani, Takeshi Nakamura, Kiyomitsu Miyachi

CORNEA, 27(8) S3-S8, Sep, 2008 Peer-reviewed
骨格筋におけるパールカンの役割の検討(平成19年度老人性疾患病態・治療研究センター研究発表会)

許卓, 二木啓, 市川直樹, 黒澤尚, 平澤(有川) 恵理

順天堂医学, 54(3) 416-416, Sep, 2008
Schwartz-Jampel症候群モデルマウスを用いたパールカンと筋収縮機構の研究

平澤恵理, 林明人, 二木啓, 家崎貴文, 服部信孝

臨床神経学, 47(12) 1114-1114, Dec, 2007
骨格筋におけるパールカンの役割の検討(平成18年度老人性疾患病態・治療研究センター研究発表会)

許卓, 二木啓, 市川直樹, 黒澤尚, 平澤(有川) 恵理

順天堂医学, 53(3) 517-517, Sep, 2007
膵外分泌を引き起こすCaシグナリングに関与するIP3受容体サブタイプ

中村健, 二木啓, 御子柴克彦

日本生理学雑誌, 68(3) 112-112, Mar, 2006
Structure and function of IP3 receptor and its role in cell function

K Mikoshiba, T Michikawa, K Hamada, H Ando, T Higo, T Nakamura, A Futatsugi, K Fukatsu, A Kuruma, J Goto …

JOURNAL OF NEUROCHEMISTRY, 94 132-133, Aug, 2005
Calcium influx into Purkinje cells is essential for activity-dependent maturation of climbing fiber innervation

Y Kiyohara, A Futatsugi, K Sakai, K Mikoshiba, T Hashikawa

JOURNAL OF NEUROCHEMISTRY, 94 113-113, Aug, 2005
Roles of type 2 and type 3 IP3 receptors in exocrine secretion

Futatsugi Akira, Nakamura Takeshi, Ebisui Etsuko, Nakamura Kyoko, Mikoshiba Katsuhiko

Proceedings of Annual Meeting of the Physiological Society of Japan, 2005 S134-S134, 2005
Effects of the P/Q-type Ca channel knockout on the cerebellar Purkinje cell synapses

Kuruma Akinori, Inoue Takafumi, Goto Jun-ichi, Futatsugi Akira, Mikoshiba Katsuhiko

Proceedings of Annual Meeting of the Physiological Society of Japan, 2005 S148-S148, 2005
Central role of M3 muscarinic acetylcholine receptor in salivary gland function in mice.

T Nakamura, M Matsui, K Uchida, A Futatsugi, T Manabe, M Taketo, K Mikoshiba

JOURNAL OF PHARMACOLOGICAL SCIENCES, 91 223P-223P, 2003
Role of IP3 receptor in neural plasticity

K Mikoshiba, T Inoue, A Futatsugi, S Fujii, H Kato

COGNITION AND EMOTION IN THE BRAIN, 1250 461-472, 2003 Peer-reviewed

Presentations

細胞の「数」から見た動物の体の成り立ちと疾患〜がんと認知症を中心に〜

二木啓

神戸研究学園都市公開講座「私たちの健康と最近の話題」, Apr 6, 2019
「神経細胞の細胞周期と神経細胞死？ - サイクリン依存性キナーゼ５(Cdk5) の研究より-」

二木啓

兵庫県高等学校教育研究会生物部会「現代生物ゼミナール」, Dec, 2017 Invited
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism

Akira Futatsugi

科学技術振興機構ICORP ライブ2005, 2005
Physiological roles of type 2 and type 3 IP3 receptors “What knockout mice tell us”

Akira Futatsugi

International Symposium on Calcium Oscillation: Molecular Mechanisms and Medical Applications of an Extraordinary Versatile Cell Signal", Nobel Forum, Stockholm, Sweden (2003), Nov, 2003
Roles of calcium channels in brain function

二木啓

The 78th Annual Meeting of the Physiological Society of Japan, Mar, 2001 Invited
Regulation of Synaptic Plasticity and Behavior by Intracellular Calcium Release Channels

二木啓

Keio Neuroscience Symposium, 2000 Invited

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特開2006-187284 IP3レセプター欠損マウス

御子柴克彦, 二木啓, 久恒智博

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