2019年4月5日
Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity.
Organic letters
- 巻
- 21
- 号
- 7
- 開始ページ
- 2180
- 終了ページ
- 2184
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.9b00483
- 出版者・発行元
- American Chemical Society (ACS)
Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.
- リンク情報
-
- DOI
- https://doi.org/10.1021/acs.orglett.9b00483
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30859827
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000464247500052&DestApp=WOS_CPL
- URL
- https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b00483
- ID情報
-
- DOI : 10.1021/acs.orglett.9b00483
- ISSN : 1523-7060
- eISSN : 1523-7052
- PubMed ID : 30859827
- Web of Science ID : WOS:000464247500052