論文

査読有り 国際誌
2021年6月29日

Gene expression level of renalase in the skeletal muscles is increased with high-intensity exercise training in mice on a high-fat diet.

Physiology international
  • Katsuyuki Tokinoya
  • ,
  • Seiko Ono
  • ,
  • Kai Aoki
  • ,
  • Koki Yanazawa
  • ,
  • Yasuhiro Shishikura
  • ,
  • Takehito Sugasawa
  • ,
  • Kazuhiro Takekoshi

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1556/2060.2021.00147

Introduction: Exercise training is beneficial for reducing obesity. In particular, exercise training can lower the catecholamine concentration in circulation. Renalase, whose expression was first confirmed in the kidneys, is a physiologically active substance that decomposes circulating catecholamines; additionally, it has been reported to be present in the skeletal muscles. The aim of this study was to clarify the expression of renalase in the skeletal muscles and kidneys after high-intensity exercise training in obese mice. Material and methods: The mice were divided into four groups: normal diet and sedentary, normal diet and exercise training, high-fat diet and sedentary, and high-fat diet and exercise training, and the test was performed for 8 weeks. Results: Body weight and skeletal muscle wet weight were reduced by high-fat diet intake but were rescued by training. Skeletal muscle renalase gene expression was significantly increased by exercise training. However, in the kidneys the gene expression of renalase was significantly increased by high-fat diet intake and exercise training. No significant changes were observed in the gene expression of catecholamine-degrading enzymes, catechol-O-methyltransferase and monoamine oxidase A and B. Conclusion: We demonstrated that exercise training increased the gene expression of renalase in the skeletal muscles and kidneys, thus lowering circulating catecholamine levels. This may lead to amelioration of obesity as catecholamines are lipolytic.

リンク情報
DOI
https://doi.org/10.1556/2060.2021.00147
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34191746
ID情報
  • DOI : 10.1556/2060.2021.00147
  • PubMed ID : 34191746

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