論文

査読有り
2012年

Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats.

Biological & pharmaceutical bulletin
  • Tohru Yamazaki
  • ,
  • Hitomi Okada
  • ,
  • Takeshi Sakamoto
  • ,
  • Katsuyoshi Sunaga
  • ,
  • Tadashi Tsuda
  • ,
  • Atsushi Mitsumoto
  • ,
  • Naomi Kudo
  • ,
  • Yoichi Kawashima

35
1
開始ページ
116
終了ページ
20
記述言語
英語
掲載種別
研究論文(学術雑誌)

The administration of fibrates (fenofibrate, bezafibrate and clofibric acid) to rats induced stearoyl-CoA desaturase (SCD) in the liver, and increased relative expression of mRNAs encoding SCD1 and SCD2 in dose- and time-dependent manners. The magnitudes of the increases in SCD2 mRNA level caused by fenofibrate and clofibric acid were much higher than those of SCD1 at relatively higher doses of the fibrates, and a relatively long time (7 or 14 d) was required for significant induction of SCD2 mRNA expression compared with that of SCD1. Although the absolute number of transcripts for SCD2 was 1,800 times lower than that of SCD1 in the control liver, it was strikingly increased by fibrates. These results suggest that differential regulations operate for the gene expression between SCD1 and SCD2, and that the physiological significance of SCD2 is distinct from that of SCD1 in the liver.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22223347
ID情報
  • eISSN : 1347-5215
  • PubMed ID : 22223347

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