Atsushi Hashizume - My portal

Profile Information

Affiliation: 名古屋大学医学部附属病院脳神経内科

J-GLOBAL ID: 202001018366586868

Research Interests

Research Areas

Life sciences / Neurology /

Research History

Oct, 2020 - Present

Nagoya University hospital Lecturer
Apr, 2019 - Sep, 2020

Nagoya University hospital Neurology Assistant professor
Sep, 2018 - Mar, 2019

Nagoya University Graduate school of medicine Department of Neurology Designated assistant professor
Apr, 2014 - Aug, 2018

Nagoya University hospital Neurology Clinical fellow
Apr, 2013 - Mar, 2014

Pharmaceuticals and Medical Devices Agency New Drug Ⅱ
Apr, 2012 - Mar, 2013

Nagoya University hospital Neurology Clinical fellow
Apr, 2008 - Mar, 2012

Nagoya University Graduate school of medicine Department of Neuology
Apr, 2002 - Mar, 2008

Nagoya Daini Red-cross hospital Neurology Clinical fellow

Education

Apr, 2008 - Mar, 2012

Nagoya University Graduate School of Medicine Department of Neurology
- Mar, 2002

Nagoya University School of Medicine
Mar, 1996

The University of Tokyo Faculty of Medicine

Awards

Papers

Disease mechanism, biomarker and therapeutics for spinal and bulbar muscular atrophy (SBMA).

Atsushi Hashizume, Kenneth H Fischbeck, Maria Pennuto, Pietro Fratta, Masahisa Katsuno

Journal of neurology, neurosurgery, and psychiatry 91(10) 1085 - 1091 Oct, 2020 Peer-reviewed
Longitudinal Change of DAT SPECT in Parkinson's Disease and Multiple System Atrophy.

Satoko Sakakibara, Rina Hashimoto, Taiji Katayama, Masakuni Kenjyo, Yuki Yokokawa, Yufuko Saito, Akihiro Hirakawa, Mizuki Ito, Tomohiko Nakamura, Kazuhiro Hara, Atsushi Hashizume, Ikuko Aiba, Akira Inukai, Masahisa Katsuno

Journal of Parkinson's disease 10(1) 123 - 130 2020 Peer-reviewed
Nasometric Scores in spinal and bulbar muscular atrophy - Effects of palatal lift prosthesis on dysarthria and dysphagia.

Seiya Tanaka, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Daisuke Ito, Atsushi Nakayama, Kenichi Kurita, Hiroaki Yogo, Haruhiko Banno, Keisuke Suzuki, Masahiko Yamamoto, Gen Sobue, Masahisa Katsuno

Journal of the neurological sciences 407 116503 - 116503 Dec 15, 2019 Peer-reviewed
Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis.

Daisuke Ito, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Yohei Iguchi, Madoka Iida, Yoshiyuki Kishimoto, Hideyuki Moriyoshi, Akihiro Hirakawa, Masahisa Katsuno

Journal of neurology 266(12) 2952 - 2961 Dec, 2019 Peer-reviewed
Long-term Effects of Androgen Deprivation in a Patient with Spinal and Bulbar Muscular Atrophy - A Case Report with 14 Years of Follow-up.

Yasuhiro Hijikata, Atsushi Hashizume, Shinichiro Yamada, Daisuke Ito, Haruhiko Banno, Keisuke Suzuki, Gen Sobue, Masahisa Katsuno

Internal medicine (Tokyo, Japan) 58(15) 2231 - 2234 Aug 1, 2019 Peer-reviewed
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.

Kunihiko Araki, Amane Araki, Daiyu Honda, Takako Izumoto, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Yohei Iguchi, Akitoshi Hara, Kazuhiro Ikumi, Kaori Kawai, Shinsuke Ishigaki, Yoko Nakamichi, Shin Tsunekawa, Yusuke Seino, Akiko Yamamoto, Yasunori Takayama, Shihomi Hidaka, Makoto Tominaga, Mica Ohara-Imaizumi, Atsushi Suzuki, Hiroshi Ishiguro, Atsushi Enomoto, Mari Yoshida, Hiroshi Arima, Shin-Ichi Muramatsu, Gen Sobue, Masahisa Katsuno

The Journal of clinical investigation 129(9) 3578 - 3593 Jul 29, 2019 Peer-reviewed
Efficacy and safety of leuprorelin acetate for subjects with spinal and bulbar muscular atrophy: pooled analyses of two randomized-controlled trials.

Atsushi Hashizume, Masahisa Katsuno, Keisuke Suzuki, Haruhiko Banno, Yu Takeuchi, Motoshi Kawashima, Noriaki Suga, Tomoo Mano, Amane Araki, Yasuhiro Hijikata, Akihiro Hirakawa, Gen Sobue

Journal of neurology 266(5) 1211 - 1221 May, 2019 Peer-reviewed
DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.

Naohide Kondo, Genki Tohnai, Kentaro Sahashi, Madoka Iida, Mayumi Kataoka, Hideaki Nakatsuji, Yutaka Tsutsumi, Atsushi Hashizume, Hiroaki Adachi, Haruki Koike, Keiko Shinjo, Yutaka Kondo, Gen Sobue, Masahisa Katsuno

EMBO molecular medicine 11(5) May, 2019 Peer-reviewed
IGF-1 for spinal and bulbar muscular atrophy: hope and challenges.

Atsushi Hashizume, Masahisa Katsuno

The Lancet. Neurology 17(12) 1026 - 1027 Dec, 2018 Peer-reviewed
Study protocol for the MEXiletine hydrochloride administration trial: a placebo-controlled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS).

Shinichiro Yamada, Atsushi Hashizume, Yasuhiro Hijikata, Tomonori Inagaki, Daisuke Ito, Fumie Kinoshita, Masahiro Nakatochi, Yumiko Kobayashi, Akihiro Hirakawa, Tomohiko Nakamura, Masahisa Katsuno

BMJ open 8(9) e023041 Sep 11, 2018 Peer-reviewed
Preclinical progression of neurodegenerative diseases.

Masahisa Katsuno, Kentaro Sahashi, Yohei Iguchi, Atsushi Hashizume

Nagoya journal of medical science 80(3) 289 - 298 Aug, 2018 Peer-reviewed
Biomarker-based analysis of preclinical progression in spinal and bulbar muscular atrophy.

Yasuhiro Hijikata, Atsushi Hashizume, Shinichiro Yamada, Tomonori Inagaki, Daisuke Ito, Akihiro Hirakawa, Keisuke Suzuki, Naoki Atsuta, Takashi Tsuboi, Makoto Hattori, Akihiro Hori, Haruhiko Banno, Gen Sobue, Masahisa Katsuno

Neurology 90(17) e1501-e1509 Apr 24, 2018 Peer-reviewed
Treatment with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial.

Yasuhiro Hijikata, Masahisa Katsuno, Keisuke Suzuki, Atsushi Hashizume, Amane Araki, Shinichiro Yamada, Tomonori Inagaki, Daisuke Ito, Akihiro Hirakawa, Fumie Kinoshita, Masahiko Gosho, Gen Sobue

JMIR research protocols 7(3) e69 Mar 5, 2018 Peer-reviewed
Long-term treatment with leuprorelin for spinal and bulbar muscular atrophy: natural history-controlled study.

Atsushi Hashizume, Masahisa Katsuno, Keisuke Suzuki, Akihiro Hirakawa, Yasuhiro Hijikata, Shinichiro Yamada, Tomonori Inagaki, Haruhiko Banno, Gen Sobue

Journal of neurology, neurosurgery, and psychiatry 88(12) 1026 - 1032 Dec, 2017 Peer-reviewed
Quantitative Assessment of Swallowing Dysfunction in Patients with Spinal and Bulbar Muscular Atrophy.

Atsushi Hashizume, Haruhiko Banno, Masahisa Katsuno, Yasuhiro Hijikata, Shinichiro Yamada, Tomonori Inagaki, Keisuke Suzuki, Gen Sobue

Internal medicine (Tokyo, Japan) 56(23) 3159 - 3165 Dec 1, 2017 Peer-reviewed
Cardiac and peripheral vasomotor autonomic functions in late-onset transthyretin Val30Met familial amyloid polyneuropathy.

Haruki Koike, Tomohiko Nakamura, Atsushi Hashizume, Ryoji Nishi, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Masahisa Katsuno, Gen Sobue

Journal of neurology 264(11) 2293 - 2302 Nov, 2017 Peer-reviewed
Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis.

Mie Takahashi, Haruki Koike, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Atsushi Hashizume, Masahisa Katsuno, Gen Sobue

Neurology(R) neuroimmunology & neuroinflammation 4(6) e407 Nov, 2017 Peer-reviewed
Swallowing markers in spinal and bulbar muscular atrophy.

Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki, Seiya Tanaka, Noriaki Suga, Atsushi Hashizume, Tomoo Mano, Amane Araki, Hirohisa Watanabe, Yasushi Fujimoto, Masahiko Yamamoto, Gen Sobue

Annals of clinical and translational neurology 4(8) 534 - 543 Aug, 2017 Peer-reviewed
Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy.

Hideaki Nakatsuji, Amane Araki, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Tomonori Inagaki, Keisuke Suzuki, Haruhiko Banno, Noriaki Suga, Yohei Okada, Manabu Ohyama, Tohru Nakagawa, Ken Kishida, Tohru Funahashi, Iichiro Shimomura, Hideyuki Okano, Masahisa Katsuno, Gen Sobue

Journal of neurology 264(5) 839 - 847 May, 2017 Peer-reviewed
Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy.

Yasuhiro Hijikata, Masahisa Katsuno, Keisuke Suzuki, Atsushi Hashizume, Amane Araki, Shinichiro Yamada, Tomonori Inagaki, Madoka Iida, Seiya Noda, Hirotaka Nakanishi, Haruhiko Banno, Tomoo Mano, Akihiro Hirakawa, Hiroaki Adachi, Hirohisa Watanabe, Masahiko Yamamoto, Gen Sobue

Annals of clinical and translational neurology 3(7) 537 - 46 Jul, 2016 Peer-reviewed
Decreased Peak Expiratory Flow Associated with Muscle Fiber-Type Switching in Spinal and Bulbar Muscular Atrophy.

Shinichiro Yamada, Atsushi Hashizume, Yasuhiro Hijikata, Tomonori Inagaki, Keisuke Suzuki, Naohide Kondo, Kaori Kawai, Seiya Noda, Hirotaka Nakanishi, Haruhiko Banno, Akihiro Hirakawa, Haruki Koike, Katherine Halievski, Cynthia L Jordan, Masahisa Katsuno, Gen Sobue

PloS one 11(12) e0168846 2016 Peer-reviewed
Myotonia-like symptoms in a patient with spinal and bulbar muscular atrophy.

Kunihiko Araki, Hirotaka Nakanishi, Tomohiko Nakamura, Naoki Atsuta, Shinichiro Yamada, Yasuhiro Hijikata, Atsushi Hashizume, Keisuke Suzuki, Masahisa Katsuno, Gen Sobue

Neuromuscular disorders : NMD 25(11) 913 - 5 Nov, 2015 Peer-reviewed
A functional scale for spinal and bulbar muscular atrophy: Cross-sectional and longitudinal study.

Atsushi Hashizume, Masahisa Katsuno, Keisuke Suzuki, Haruhiko Banno, Noriaki Suga, Tomoo Mano, Amane Araki, Yasuhiro Hijikata, Christopher Grunseich, Angela Kokkinis, Akihiro Hirakawa, Hirohisa Watanabe, Masahiko Yamamoto, Kenneth H Fischbeck, Gen Sobue

Neuromuscular disorders : NMD 25(7) 554 - 62 Jul, 2015 Peer-reviewed
Head Lift Exercise Improves Swallowing Dysfunction in Spinal and Bulbar Muscular Atrophy.

Tomoo Mano, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Noriaki Suga, Atsushi Hashizume, Amane Araki, Yasuhiro Hijikata, Seiya Tanaka, Jun Takatsu, Hirohisa Watanabe, Masahiko Yamamoto, Gen Sobue

European neurology 74(5-6) 251 - 8 2015 Peer-reviewed
Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.

Noriaki Suga, Masahisa Katsuno, Haruki Koike, Haruhiko Banno, Keisuke Suzuki, Atsushi Hashizume, Tomoo Mano, Masahiro Iijima, Yuichi Kawagashira, Masaaki Hirayama, Tomohiko Nakamura, Hirohisa Watanabe, Fumiaki Tanaka, Gen Sobue

Neuropathology and applied neurobiology 40(5) 628 - 39 Aug, 2014 Peer-reviewed
Brugada syndrome in spinal and bulbar muscular atrophy.

Amane Araki, Masahisa Katsuno, Keisuke Suzuki, Haruhiko Banno, Noriaki Suga, Atsushi Hashizume, Tomoo Mano, Yasuhiro Hijikata, Hideaki Nakatsuji, Hirohisa Watanabe, Masahiko Yamamoto, Takeru Makiyama, Seiko Ohno, Megumi Fukuyama, Shin-Ichiro Morimoto, Minoru Horie, Gen Sobue

Neurology 82(20) 1813 - 21 May 20, 2014 Peer-reviewed
Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm.

Seiya Tanaka, Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki, Noriaki Suga, Atsushi Hashizume, Tomoo Mano, Amane Araki, Hirohisa Watanabe, Hiroaki Adachi, Hiroshi Tatsumi, Masahiko Yamamoto, Gen Sobue

Journal of the neurological sciences 337(1-2) 193 - 200 Feb 15, 2014 Peer-reviewed
Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy.

Tomoo Mano, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Noriaki Suga, Atsushi Hashizume, Amane Araki, Hirohisa Watanabe, Seiya Tanaka, Masahiko Yamamoto, Gen Sobue

Neurology 82(3) 255 - 62 Jan 21, 2014 Peer-reviewed
Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy.

Tomoo Mano, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Noriaki Suga, Atsushi Hashizume, Fumiaki Tanaka, Gen Sobue

Muscle & nerve 46(5) 692 - 7 Nov, 2012 Peer-reviewed
[109th Scientific Meeting of the Japanese Society of Internal Medicine: symposium: 2. Translational research and evidence-based medicine (EBM) in internal medicine in Japan, translational research; 1) Translational research on neurodegenerative diseases].

Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Atsushi Hashizume, Hiroaki Adachi, Fumiaki Tanaka, Gen Sobue

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 101(9) 2533 - 8 Sep 10, 2012 Peer-reviewed
Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy.

Atsushi Hashizume, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Noriaki Suga, Tomoo Mano, Naoki Atsuta, Hiroaki Oe, Hirohisa Watanabe, Fumiaki Tanaka, Gen Sobue

Brain : a journal of neurology 135(Pt 9) 2838 - 48 Sep, 2012 Peer-reviewed
Difference in chronological changes of outcome measures between untreated and placebo-treated patients of spinal and bulbar muscular atrophy.

Atsushi Hashizume, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Noriaki Suga, Fumiaki Tanaka, Gen Sobue

Journal of neurology 259(4) 712 - 9 Apr, 2012 Peer-reviewed
[Anti-androgen therapy for spinal and bulbar muscular atrophy (SBMA)].

Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Atsushi Hashizume, Hiroaki Adachi, Fumiaki Tanaka, Gen Sobue

Rinsho shinkeigaku = Clinical neurology 52(11) 1207 - 9 2012 Peer-reviewed
The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy.

Keisuke Suzuki, Masahisa Katsuno, Haruhiko Banno, Yu Takeuchi, Motoshi Kawashima, Noriaki Suga, Atsushi Hashizume, Tetsuo Hama, Kei Uchida, Fumitada Yamashita, Tomohiko Nakamura, Masaaki Hirayama, Fumiaki Tanaka, Gen Sobue

Journal of neurology, neurosurgery, and psychiatry 81(5) 567 - 71 May, 2010 Peer-reviewed

Misc.

【遺伝性疾患治療の最前線】球脊髄性筋萎縮症

橋詰淳, 勝野雅央

遺伝子医学 10(2) 26 - 31 Apr, 2020
【神経疾患の現在とこれから】診療の最前線球脊髄性筋萎縮症

橋詰淳, 祖父江元, 勝野雅央

内科 123(6) 1259 - 1261 Jun, 2019
【運動ニューロン疾患-治療の展望】球脊髄性筋萎縮症(SBMA)のリュープロレリンによる治療

祖父江元, 橋詰淳, 鈴木啓介, 足立弘明, 勝野雅央

脳神経内科 90(2) 122 - 130 Feb, 2019
【研修医が知っておきたい神経疾患の診断と治療】運動ニューロン疾患

山田晋一郎, 橋詰淳, 勝野雅央

月刊レジデント 11(10) 31 - 39 Dec, 2018
【神経・筋疾患に対する治療の進歩】運動ニューロン疾患

熱田直樹, 橋詰淳, 祖父江元, 勝野雅央

日本内科学会雑誌 107(8) 1477 - 1485 Aug, 2018
【神経・筋難病治療の最前線】球脊髄性筋萎縮症における疾患修飾療法の開発

橋詰淳, 祖父江元, 勝野雅央

BIO Clinica 33(8) 729 - 734 Jul, 2018
球脊髄性筋萎縮症これからの治療

勝野雅央, 土方靖浩, 橋詰淳, 祖父江元

神経治療学 35(4) 427 - 431 Jul, 2018
【ドラッグリポジショニング-新たな治療戦略】基礎研究とドラッグリポジショニングの治験計画と実施

橋詰淳, 鈴木啓介, 足立弘明, 祖父江元, 勝野雅央

カレントテラピー 36(5) 453 - 459 May, 2018
【神経内科診断推論】主訴で神経内科診断を推論する脱力・運動麻痺

土方靖浩, 橋詰淳, 勝野雅央

Modern Physician 37(7) 687 - 690 Jul, 2017
神経変性疾患に対するリバーストランスレーショナルリサーチの基盤としての患者レジストリおよびバイオバンク

勝野雅央, 橋詰淳, 中村治雅, 小野賢二郎, 湯地晃一郎, 山田雅信, 渡邉琢也, 一丸勝彦, 加藤直人, 井上隆弘, 草間真紀子, 水島洋, 藤本陽子, 秋元周, 小林潔, 大脇健二, 上杉幸嗣

臨床薬理 48(4) 141 - 147 Jul, 2017
人工呼吸療法球脊髄性筋萎縮症患者の呼吸機能

山田晋一郎, 橋詰淳, 勝野雅央

難病と在宅ケア 23(3) 37 - 40 Jun, 2017
【神経疾患の早期診断】球脊髄性筋萎縮症の早期診断

土方靖浩, 橋詰淳, 祖父江元, 勝野雅央

神経内科 86(1) 17 - 22 Jan, 2017
【アカデミア発の創薬・研究治療】球脊髄性筋萎縮症(SBMA)に対する抗アンドロゲン療法

鈴木啓介, 勝野雅央, 橋詰淳, 坂野晴彦, 祖父江元

神経内科 83(4) 271 - 276 Oct, 2015
アカデミア発の創薬球脊髄性筋萎縮症(SBMA)に対する抗アンドロゲン療法

勝野雅央, 坂野晴彦, 鈴木啓介, 橋詰淳, 足立弘明, 田中章景, 祖父江元

臨床神経学 52(11) 1207 - 1209 Nov, 2012
【神経筋疾患の分子標的治療開発】神経変性疾患の分子標的治療への問題点 SBMAを中心に

坂野晴彦, 勝野雅央, 鈴木啓介, 橋詰淳, 祖父江元

BIO Clinica 27(10) 946 - 950 Sep, 2012
我が国の内科領域のトランスレーショナルリサーチとEBM トランスレーショナルリサーチ神経変性疾患のトランスレーショナルリサーチ

勝野雅央, 坂野晴彦, 鈴木啓介, 橋詰淳, 足立弘明, 田中章景, 祖父江元

日本内科学会雑誌 101(9) 2533 - 2538 Sep, 2012
我が国の内科領域のトランスレーショナルリサーチとEBM トランスレーショナルリサーチ神経変性疾患のトランスレーショナルリサーチ

勝野雅央, 坂野晴彦, 鈴木啓介, 橋詰淳, 足立弘明, 田中章景, 祖父江元

日本内科学会雑誌 101(Suppl.) 113 - 113 Feb, 2012

Research Projects

球脊髄性筋萎縮症に対する骨格筋トランスポーターを標的とした治療法開発

日本学術振興会科学研究費助成事業基盤研究(C) Apr, 2018 - Mar, 2021

土方靖浩, 橋詰淳, 勝野雅央
Long-term effect of leuprorelin acetate on the patients with spinal and bulbar muscular atrophy

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Apr, 2018 - Mar, 2021
Elucidation of defective neural communication in motor neuron diseases

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Apr, 2017 - Mar, 2020
Biomarker study in the early phase patients with spinal and bulbar muscular atrophy

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Apr, 2015 - Mar, 2018

Hashizume Atsushi