論文

査読有り
2019年8月1日

Long-term Effects of Androgen Deprivation in a Patient with Spinal and Bulbar Muscular Atrophy - A Case Report with 14 Years of Follow-up.

Internal medicine (Tokyo, Japan)
  • Yasuhiro Hijikata
  • ,
  • Atsushi Hashizume
  • ,
  • Shinichiro Yamada
  • ,
  • Daisuke Ito
  • ,
  • Haruhiko Banno
  • ,
  • Keisuke Suzuki
  • ,
  • Gen Sobue
  • ,
  • Masahisa Katsuno

58
15
開始ページ
2231
終了ページ
2234
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.1592-18

Spinal and bulbar muscular atrophy (SBMA) is a progressive hereditary neuromuscular disease caused by the testosterone-dependent accumulation of pathogenic polyglutamine-expanded androgen receptor protein. A 41-year-old man with SBMA received the androgen deprivation agent leuprorelin acetate for 7 years in clinical trials and underwent castration following the trial. Suppression of testosterone levels for 14 years resulted in a slower disease progression, as measured prospectively with quantitative measurements, than the historical control data reported in previous studies. This suggests that long-term androgen deprivation delays disease progression in SBMA.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.1592-18
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30996158
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709315

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