BABA TOMOHISA

Profile Information

Affiliation: Associate Professor, Cancer Research Institute, Kanazawa University

J-GLOBAL ID: 201801008519577096
researchmap Member ID: B000304403

Research Interests

Research Areas

Research History

Nov, 2017 - Present

Cancer Research Institute, Kanazawa University
Apr, 2007 - Oct, 2017

Cancer Research Institute, Kanazawa University
Apr, 2006 - Mar, 2007

派遣研究員, 財団法人ヒューマンサイエンス振興財団
Apr, 2003 - Mar, 2006

Graduate School of Medicine, Hokkaido University

Education

Apr, 2003 - Mar, 2006

Graduate School of Medicine, Hokkaido University
Apr, 1997 - Mar, 2003

Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University

Awards

Jul, 2009

The young investigator award, 17th International Symposium on Molecular Cell Biology of Macrophages

BABA TOMOHISA

Papers

Autophagy inhibition-induced cytosolic DNA sensing combined with differentiation therapy induces irreversible myeloid differentiation in leukemia cells.

Tomohisa Baba, Utano Tomaru, Atsushi Hirao, Naofumi Mukaida, Yoshikazu Johmura

Cancer research communications, Mar 11, 2024
CCR2- and CCR5-mediated macrophage infiltration contributes to glomerular endocapillary hypercellularity in antibody-induced lupus nephritis.

Takeshi Zoshima, Tomohisa Baba, Yamato Tanabe, Yuko Ishida, Kimihiko Nakatani, Michio Nagata, Naofumi Mukaida, Mitsuhiro Kawano

Rheumatology (Oxford, England), 61(7) 3033-3048, Jul 6, 2022
Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.

So-Ichiro Sasaki, Di Zhang, Sadahiro Iwabuchi, Yamato Tanabe, Shinichi Hashimoto, Akira Yamauchi, Katsuhiro Hayashi, Hiroyuki Tsuchiya, Yoshihiro Hayakawa, Tomohisa Baba …

Cancer science, 112(12) 4883-4893, Dec, 2021
Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia

Naofumi Mukaida, Yamato Tanabe, Tomohisa Baba

Molecular Biomedicine, 2(1), Dec, 2021
Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway.

Tomohisa Baba, Takeshi Yoshida, Yamato Tanabe, Tatsunori Nishimura, Soji Morishita, Noriko Gotoh, Atsushi Hirao, Rikinari Hanayama, Naofumi Mukaida

Cell death & disease, 12(4) 322-322, Mar 26, 2021
Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis.

Yamato Tanabe, Shimpei Kawamoto, Tomoiku Takaku, Soji Morishita, Atsushi Hirao, Norio Komatsu, Eiji Hara, Naofumi Mukaida, Tomohisa Baba

Blood advances, 4(24) 6175-6188, Dec 22, 2020
Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone.

Di Zhang, Sadahiro Iwabuchi, Tomohisa Baba, Shin-Ichi Hashimoto, Naofumi Mukaida, So-Ichiro Sasaki

Cancers, 12(10), Oct 16, 2020
Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression.

Naofumi Mukaida, So-Ichiro Sasaki, Tomohisa Baba

International journal of molecular sciences, 21(10), May 14, 2020
CCL4 Signaling in the Tumor Microenvironment.

Naofumi Mukaida, So-Ichiro Sasaki, Tomohisa Baba

Advances in experimental medicine and biology, 1231 23-32, 2020
Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells

Mukaida N, Nosaka T, Nakamoto Y, Baba T

International Journal of Molecular Sciences, 20(1), Dec, 2018 Peer-reviewed
Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.

Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N

Molecular cancer therapeutics, 17(7) 1515-1525, Jul, 2018 Peer-reviewed
Alveolar macrophages drive hepatocellular carcinoma lung metastasis by generating leukotriene B4

Takuto Nosaka, Tomohisa Baba, Yamato Tanabe, Soichiro Sasaki, Tatsunori Nishimura, Yoshiaki Imamura, Hideaki Yurino, Shinichi Hashimoto, Makoto Arita, Yasunari Nakamoto …

Journal of Immunology, 200(5) 1839-1852, Mar 1, 2018 Peer-reviewed
Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia

Naofumi Mukaida, Yamato Tanabe, Tomohisa Baba

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), Aug, 2017 Peer-reviewed
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis

Soichiro Sasaki, Tomohisa Baba, Tatsunori Nishimura, Yoshihiro Hayakawa, Shin-ichi Hashimoto, Noriko Gotoh, Naofumi Mukaida

CANCER LETTERS, 378(1) 23-32, Aug, 2016 Peer-reviewed
Gemcitabine induces cell senescence in human pancreatic cancer cell lines

Yao Song, Tomohisa Baba, Naofumi Mukaida

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(3) 515-519, Aug, 2016 Peer-reviewed
Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation

Yamato Tanabe, Soichiro Sasaki, Naofumi Mukaida, Tomohisa Baba

ONCOTARGET, 7(30) 48335-48345, Jul, 2016 Peer-reviewed
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.

Baba, T, Tanabe, Y, Yoshikawa, S, Yamanishi, Y, Morishita, S, Komatsu, N, Karasuyama, H, Hirao, A, Mukaida N

Blood, 127(21) 2607-2617, May, 2016 Peer-reviewed
MIP-1 alpha/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice

Tomohisa Baba, Yamato Tanabe, Soichiro Yoshikawa, Yoshinori Yamanishi, Soji Morishita, Norio Komatsu, Hajime Karasuyama, Atsushi Hirao, Naofumi Mukaida

BLOOD, 127(21) 2607-2617, May, 2016 Peer-reviewed
[Chemokines in chronic myeloid leukemia].

Mukaida N, Baba T

[Rinsho ketsueki] The Japanese journal of clinical hematology, 57(2) 129-136, Feb, 2016 Peer-reviewed
High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites

Tatsushi Naito, Tomohisa Baba, Kazuyoshi Takeda, Soichiro Sasaki, Yasunari Nakamoto, Naofumi Mukaida

CANCER LETTERS, 366(1) 93-99, Sep, 2015 Peer-reviewed

Misc.

がんの浸潤と転移、今までとこれから肺胞マクロファージは間質マクロファージと連携してLTB4を産生することで肺転移を促進させる(Cancer invasion and metastasis - A summary and the future Alveolar macrophages drive lung metastasis in cooperation with interstitial macrophages by generating leukotriene B4)

野阪拓人, 馬場智久, 田辺和, 佐々木宗一郎, 有田誠, 中本安成, 向田直史

日本癌学会総会記事, 77回 89-89, Sep, 2018
The recruited CCR2-expressing alveolar macrophages under the guidance of interstitial macrophage-derived CCL2 drive hepatocellular carcinoma lung metastasis by generating leukotriene B-4

Takuto Nosaka, Tomohisa Baba, Yamato Tanabe, Soichiro Sasaki, Makoto Arita, Yasunari Nakamoto, Naofumi Mukaida

CYTOKINE, 100 119-119, Dec, 2017
Involvement of a chemokine, CCL3, in chemotherapeutic-induced tumor eradication by rapid recruitment of CD4-positive cytotoxic T cells into tumor sites

Tomohisa Baba, Kazuyoshi Takeda, Soichiro Sasaki, Yasunari Nakarnoto, Naofumi Mukaida, Tatsushi Naito

CYTOKINE, 100 58-58, Dec, 2017
Context-dependent diverse roles of CCR5-mediated signals in chronic myeloid leukemia (CML) pathogenesis

Tomohisa Baba, Naofumi Mukaida, Yamato Tanabe

CYTOKINE, 100 177-178, Dec, 2017
Pathological contribution of an inflammatory chemokine CCL3 in chronic myeloid leukemia as a stem cell inhibitor

Tomohisa Baba, Naofumi Mukaida

CYTOKINE, 100 66-66, Dec, 2017
5-fluorouracil-induced neutrophilic chemokine expression in tumor cells is associated with accelerated lung metastasis of breast cancer

Soichiro Sasaki, Tomohisa Baba, Naofumi Mukaida

CYTOKINE, 100 182-183, Dec, 2017
Leukotriene B-4 Generated by Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis

Takuto Nosaka, Tomohisa Baba, Tatsushi Naito, Masahiro Ohtani, Katsushi Hiramatsu, Tomoyuki Nemoto, Makoto Arita, Naofumi Mukaida, Yasunari Nakamoto

HEPATOLOGY, 66 85A-85A, Oct, 2017
肺胞マクロファージはLTB4を産生することで肝細胞癌肺転移を促進させる

野阪拓人, 馬場智久, 佐々木宗一郎, 有田誠, 中本安成, 向田直史

日本癌学会総会記事, 76回 P-3104, Sep, 2017
肺胞マクロファージは、肺転移において重要な役割を果たしている

野阪拓人, 馬場智久, 佐々木宗一郎, 中本安成, 向田直史

日本癌学会総会記事, 75回 P-3164, Oct, 2016
CCIA can promote bone metastasis of a murine breast cancer cell line, by interacting CCR5-expressing non-tumor cells in bone marrow

Naofumi Mukaida, Soichiro Sasaki, Tomohisa Baba

CYTOKINE, 76(1) 70-70, Nov, 2015
Chemokine CCL3/CCR5-recruited, Cytotoxic CD4(+) T Cells Eradicate Hepatoma Cells in a Model of Anticancer Chemotherapy with High-Dose Cyclophosphamide

Tatsushi Naito, Tomohisa Baba, Kazuyoshi Takeda, Soichiro Sasaki, Naofumi Mukaida, Yasunari Nakamoto

HEPATOLOGY, 62 1240A-1240A, Oct, 2015
Uptake of blood-borne antigens and induction of regulatory T cells by thymic dendritic cells

59(4) 430-437, Apr, 2013
Crucial involvement of the CCL3-CCR5 axis in fibrosis accompanied with mouse chronic colitis-associated carcinogenesis

N. Mukaida, T. Baba, S. Sasaki

CYTOKINE, 59(3) 572-572, Sep, 2012
Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes

87(2) 68-68, Apr 1, 2012
Ablation of CC chemokine receptor 2 gene exacerbates the polyarthritis in interleukin-1 receptor antagonist-deficient mice

Naofumi Mukaida, Hiroshi Fujii, Tomohisa Baba

CYTOKINE, 56(1) 71-71, Oct, 2011
PRE-CLINICAL EVALUATION OF ECI301, A VARIANT OF HUMAN CC CHEMOKINE LIGAND 3, IN THE TREATMENT WITH RADIO-FREQUENCY ABLATION FOR MURINE HEPATOMA

Noriho Iida, Yasunari Nakamoto, Hidetoshi Nakagawa, Tomohisa Baba, Eishiro Mizukoshi, Naofumi Mukaida, Shuichi Kaneko

HEPATOLOGY, 52(4) 943A-943A, Oct, 2010
Establishment of central tolerance against blood-borne antigens by thymic Sirp alpha plus conventional dendritic cells

Tomohisa Baba, Naofumi Mukaida

JOURNAL OF IMMUNOLOGY, 184, Apr, 2010
ヒト末梢血に検出されるCD8陽性単球・顆粒球の解析

MASUDA SAKIKO, IWASAKI SATOSHI, BABA TOMOHISA, KATSUMATA KAZUAKI, TOMARU UTANO, KASAHARA MASANORI, ISHIZU AKIHIRO

日本病理学会会誌, 99(1) 217-217, Mar 26, 2010
ヒト末梢血に検出されるCD8陽性単球・顆粒球の解析

益田紗季子, 岩崎沙理, 馬場智久, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋

日本病理学会会誌, 99(1) 217-217, Mar, 2010
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fiborblasts, and promotes angiogenesis in murine lung metastasis process

WU Yu

Journal of the Juzen Medical Society, 118(2) 40-42, Jun 1, 2009

Books and Other Publications

炎症と免疫: 炎症性ケモカインCCL3と白血病発症過程

馬場智久 (Role: Contributor)

Mar, 2016
臨床血液特集「臨床血液学―最新情報と今後の展望2016（骨髄系疾患）: 慢性骨髄性白血病とケモカイン

向田直史, 馬場智久 (Role: Contributor)

Feb, 2016

Presentations

慢性骨髄性白血病におけるケモカインCCL3を介した正常・白血病性造血間でのクロストーク

馬場智久

日本病理学会, Jun 22, 2018 Invited
Pathological contribution of an inflammatory chemokine CCL3 in chronic myeloid leukemia as a stem cell inhibitor

BABA TOMOHISA, MUKAIDA NAOFUMI

5th Annual meeting of the international cytokine and interferon society, Oct 31, 2017 Invited
CCL3-expressing basophil-like leukemia cells drive the pathogenesis of chronic myeloid leukemia

BABA TOMOHISA

Apr 4, 2016 Invited
Unique role of thymic Sirpα+ dendritic cell subpopulation in the establishment of central tolerance

BABA TOMOHISA, MUKAIDA NAOFUMI

6th Annual Symposium on Primary Immunodeficiency Diseases, Nov 20, 2010 Invited
CD4/CD8 double positive マクロファージの発見と自然免疫系における新しいエフェクター細胞としての展開

馬場智久

日本病理学会, May 15, 2008 Invited

Professional Memberships

Research Projects

Spacio-temporal analysis of the chemokine system during the course of aortic aneurysm formation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
ドナー細胞由来白血病の発症にかかわる細胞外小胞の病態生理学的役割の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

馬場智久
Elucidation of the roles of extracellular microsomes in donor cell-derived leukemia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Mukaida Naofumi
慢性骨髄性白血病における炎症性ケモカインCCL3の病態生理学的役割の解明

基盤研究（C）, 日本学術振興会, Apr, 2016 - Mar, 2019

馬場智久
慢性骨髄性白血病発症における正常骨髄細胞との相互作用機構の解明

基盤研究（C）, 日本学術振興会, Apr, 2013 - Mar, 2016

馬場智久
骨髄移植療法を基盤とした新たな白血病治療戦略の確立

上原記念研究奨励助成金, 2016

馬場智久
幹細胞抑制因子CCL3を分子標的とした慢性骨髄性白血病の新規治療法の確立

武田科学振興財団研究助成, 2015

馬場智久
炎症性ケモカインを分子標的とした慢性骨髄性白血病の新規治療法の確立

第43回かなえ医薬振興財団助成, 2014

馬場智久
慢性骨髄性白血病の増悪に関与する、炎症性ケモカインを介した骨髄内微小環境の構築機序の解明

第28回北國がん基金助成, 2014

馬場智久
慢性骨髄性白血病における炎症性ケモカインの分子病態生理学的役割の解明

第6回北陸銀行若手研究者助成金, 2014

馬場智久
胸腺Sirpα＋樹状細胞による自己免疫寛容の新規誘導メカニズムの解明

若手研究（B）, 日本学術振興会, Apr, 2011 - Mar, 2013

馬場智久
胸腺Sirpα＋樹状細胞の機能的特徴と自己免疫寛容における役割の解明

若手研究（B）, 日本学術振興会, Apr, 2009 - Mar, 2011

馬場智久
CD4＋CD8＋マクロファージの抗腫瘍メカニズムと免疫学的役割に関する研究

若手研究（スタートアップ）, 日本学術振興会, 2007 - Mar, 2009

馬場智久

Industrial Property Rights

特願2016-25365 慢性骨髄性白血病治療剤及び該治療剤をスクリーニングする方法

向田直史, 馬場智久
特願2013-011556 慢性骨髄性白血病モデル動物

馬場智久, 向田直史

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

Industrial Property Rights

Menu

Coauthors