Miyake Yasuyuki

Profile Information

Affiliation: Designated associate professor, Graduate School of Medicine, Nagoya University

Degree: 博士（医学）(Mar, 2006, 大阪大学)

J-GLOBAL ID: 201901012607204415
researchmap Member ID: B000364357

Research Areas

Research Interests

Papers

Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways

Longlong Wang, Etori Aguiar Moreira, Georg Kempf, Yasuyuki Miyake, Blandina I. Oliveira Esteves, Amal Fahmi, Jonas V. Schaefer, Birgit Dreier, Yohei Yamauchi, Marco P. Alves …

Cell Reports, 39(4) 110736-110736, Apr, 2022 Peer-reviewed
A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis

Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Keisuke Mantoku, Ken Sago, Yusuke Yanagi, Takeshi Suzuki, H. M. Abdullah Al Masud …

Cancer Science, 112(12) 5088-5099, Dec, 2021 Peer-reviewed
467

Influenza virus uses transportin 1 for vRNP debundling during cell entry

Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y

Nature Microbiology, 4 578-586, Jan, 2019 Peer-reviewed
159

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

Yasuyuki Miyake, Jeremy J. Keusch, Longlong Wang, Makoto Saito, Daniel Hess, Xiaoning Wang, Bruce J. Melancon, Paul Helquist, Heinz Gut, Patrick Matthias

NATURE CHEMICAL BIOLOGY, 12(9) 748-+, Sep, 2016 Peer-reviewed
Acetylation site specificities of lysine deacetylase inhibitors in human cells

Christian Scholz, Brian T. Weinert, Sebastian A. Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars J. Jensen, Werner Streicher, Anna R. McCarthy, Nicholas J. Westwood …

NATURE BIOTECHNOLOGY, 33(4) 415-U136, Apr, 2015 Peer-reviewed
141

Influenza A virus uses the aggresome processing machinery for host cell entry

Indranil Banerjee, Yasuyuki Miyake, Samuel Philip Nobs, Christoph Schneider, Peter Horvath, Manfred Kopf, Patrick Matthias, Ari Helenius, Yohei Yamauchi

SCIENCE, 346(6208) 473-477, Oct, 2014 Peer-reviewed
Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.

Christian S Eichinger, Takeshi Mizuno, Keiko Mizuno, Yasuyuki Miyake, Ken-ichiro Yanagi, Naoko Imamoto, Fumio Hanaoka

The Journal of biological chemistry, 284(44) 30604-14, Oct 30, 2009 Peer-reviewed
189

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

Yasuyuki Miyake, Mirai Nakamura, Akira Nabetani, Shintaro Shimamura, Miki Tamura, Shin Yonehara, Motoki Saito, Fuyuki Ishikawa

MOLECULAR CELL, 36(2) 193-206, Oct, 2009 Peer-reviewed
Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation

Y Miyake, T Mizuno, K Yanagi, F Hanaoka

JOURNAL OF BIOLOGICAL CHEMISTRY, 280(13) 12643-12652, Apr, 2005 Peer-reviewed

Misc.

重症ウイルス感染症／ウイルス関連腫瘍を制御するための宿主因子探索と創薬応用

佐藤好隆, 渡辺崇広, 三宅康之, 木村宏

最先端ナノライフシステム研究, 24-29, Mar, 2022
Purification of Unanchored Polyubiquitin Chains from Influenza Virions

Miyake Y, Matthias P, Yamauchi Y

Methods in Molecular Biology, 1836 329-342, 2018 Invited
Insigths into the acetylation pattern of HDAC inhibitors and their potential role in HIV therapy

Christian Schoelz, Brian Weinert, Sebastian Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars Jensen, Werner Streicher, Anna McCarthy, Nicholas Westwood …

RETROVIROLOGY, 13, Sep, 2016
ヒストン脱アセチル化酵素HDAC6の結晶構造から明らかにされたチューブリンに対する特異性および選択的な阻害剤との結合

三宅康之, パトリックマティアス

ライフサイエンス新着論文レビュー, Aug, 2016 Invited
Sequestering of aberrant DNA polymerase a in the cytoplasm suggests the presence of a quality control mechanism

Takeshi Mizuno, Christian Eichinger, Ken-Ichiro Yanagi, Yasuyuki Miyake, Fumio Hanaoka

CELL STRUCTURE AND FUNCTION, 30 39-39, Jun, 2005
Alternative splicing variant of mouse Orc1 is deficient for nuclear translocation

Yasuyuki Miyake, Takeshi Mizuno, Ken-ichiro Yanagi, Fumio Hanaoka

CELL STRUCTURE AND FUNCTION, 29 62-62, May, 2004

Books and Other Publications

Influenza A Virus: Cellular Entry

Yasuyuki Miyake, Yuya Hara, Miki Umeda, Indranil Banerjee (Role: Joint author)

Springer, 2023
インフルエンザウイルスの細胞内侵入の生化学

三宅康之, 山内洋平 (Role: Joint author)

日本生化学会, Jun, 2022
Molecular function of host factors involved in cellular entry of influenza A virus

Yasuyuki Miyake

May, 2022

Awards

Jan, 2019

CMM Awayday Best Poster Prize, Influenza virus uses transportin 1 for vRNP debundling during cell entry, University of Bristol

Miyake Yasuyuki
Jan, 2016

Pfizer Forschungspreis, Infektiologie, Rheumatologie, und Immunologie, Pfizer

Indranil Banerjee, Miyake Yasuyuki, Yohei Yamauchi

Industrial Property Rights

特願WO2015189816 A1 New treatment against influenza virus

Banerjee I, Helenius A, Matthias P, Miyake Y, Yamauchi Y

Major Research Projects

ウイルス感染における宿主因子の動態と分子機能の解明

創発的研究支援事業, 科学技術新興機構, Apr, 2021 - Mar, 2024

Professional Memberships

Apr, 2022 - Present

日本細胞生物学会
Oct, 2020 - Present

日本ウイルス学会
2002 - Present

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Other

Paternity leave

Dec, 2015 - Dec, 2015

From Dec. 2015 to Apr. 2016, paternity leave

Research History

Apr, 2023 - Present

Designated associate professor, Graduate School of Medicine, Nagoya University
Apr, 2020 - Mar, 2023

Graduate School of Medicine, Program in Integrated Medicine, Nagoya University
May, 2018 - Mar, 2020

Visiting Scientist, Faculty of Life Sciences, School of Cellular and Molecular Medicine, University of Bristol
Apr, 2018 - Mar, 2020

JSPS Research Fellow (RPD), Graduate School of Medicine Program in Integrated Medicine, Nagoya University
Mar, 2010 - Dec, 2015

Postdoctoral fellow, Friedrich Miescher Institute for Biomedical Research
Mar, 2006 - Mar, 2010

Postdoctoral fellow, Graduate School of Biostudies, Kyoto University

Presentations

Role of endosomal acidification in RNA virus uncoating

Yuya Hara, Aya Yano, Miki Umeda, Atzin Bolanos-Ceron, Hiroshi Kimura, Yohei Yamauchi, Yasuyuki Miyake

The 46th Annual Meeting of the Molecular Biology Society of Japan, Dec 6, 2023
Molecular insights into the assembly and debundling of vRNPs of influenza A virus

Aya Yano, Yuya Hara, Yasuyuki Miyake, Atzin Bolanos-Ceron, Yohei Yamauchi, Hiroshi Kimura

Dec 6, 2023
Host deubiquitinating enzyme USP7 and histone deacetylase HDAC6 function during uncoating of influenza A virus

The 70th Annual Meeting of the Japanese Society for Virology, Sep 28, 2023
Molecular mechanisms of uncoating in human coronavirus 229E

Nov 15, 2022
宿主タンパク質を介したウイルス脱殻反応の分子機構解明

原優矢, 三宅康之, 山内洋平, 木村宏

第69回日本ウイルス学会学術集会, Nov 15, 2022
Elucidating the interactions between Influenza A Matrix Protein M1 and host cell factor Transportin-1 during vRNP debundling

Nov 14, 2022
USP7 promotes influenza A virus uncoating at late endosomes

Alina Rozanova, Takahiro Watanabe, Naoki Narita, Yasuyuki Miyake, Yohei Yamauchi

Jun 28, 2022
INSIGHTS INTO INFLUENZA A VIRUS VRNP DEBUNDLING

Yuya Hara, Hiroshi Kimura, Yasuyuki Miyake, Yohei Yamauchi

Negative Strand Virus Meeting 2022, Jun 13, 2022
HOW INFLUENZA A VIRUS MATRIX PROTEIN M1 INTERACTS WITH HOST CELL FACTOR TRANSPORTIN-1 DURING VRNP DEBUNDLING

Atzin Ceron, Yasuyuki Miyake, Yohei Yamauchi, Hiroshi Kimura

Negative Strand Virus Meeting 2022, Jun 13, 2022
ENDOSOMAL DEUBIQUITINASE USP7 PROMOTES INFLUENZA VIRUS UNCOATING

Alina Rozanova, Takahiro Watanabe, Naoki Narita, Hiroshi Kimura, Yasuyuki Miyake, Yohei Yamauchi

Negative Strand Virus Meeting 2022, Jun 13, 2022
MOLECULAR MECHANISMS OF HUMAN CORONAVIRUS ENDOSOMAL UNCOATING

Miki Umeda, Tatsuki Tanito, Yoshitaka Sato, Mark Marsh, Hiroshi Kimura, Yohei Yamauchi, Yasuyuki Miyake

Negative Strand Virus Meeting 2022, Jun 12, 2022
宿主因子を標的とした新規抗ウイルス薬の探索に向けて

三宅康之

中部地区医療・バイオ系シーズ発表会, Dec 7, 2021 Invited

Teaching Experience

Feb, 2022 - Present

ウイルス学 (RNAウイルス) (名古屋市立大学医学部)
Oct, 2020 - Present

基礎医学セミナー (名古屋大学医学部)
Apr, 2020 - Present

Practical course in virology (Nagoya University)
Apr, 2020 - Present

Molecular Pathology (Nagoya University Graduate School of Medicine)
Apr, 2020 - Present

Microorganisms and Human (Nagoya University School of Medicine)
Dec, 2023 - Dec, 2023

TOKURON (Nagoya University Graduate School of Medicine/RIEM)
2018 - 2019

Laboratory practice for summer intern (University of Bristol)

Profile Information

Research Areas

Research Interests

Papers

Misc.

Books and Other Publications

Awards

Industrial Property Rights

Major Research Projects

Professional Memberships

Other

Research History

Presentations

Teaching Experience

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