2018年5月1日
Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications
Bioorganic and Medicinal Chemistry
- ,
- ,
- 巻
- 26
- 号
- 8
- 開始ページ
- 1393
- 終了ページ
- 1411
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.bmc.2018.01.026
- 出版者・発行元
- Elsevier Ltd
Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds that bind to the minor groove of double-stranded DNA in a sequence-specific manner without causing denaturation of the DNA. These compounds can be used to control gene expression and to stain specific sequences in cells. Here, we review the history, structural variations, and functional investigations of Py–Im polyamides.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmc.2018.01.026
- ISSN : 1464-3391
- ISSN : 0968-0896
- PubMed ID : 29439914
- SCOPUS ID : 85044854559