論文

査読有り
2018年5月1日

Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications

Bioorganic and Medicinal Chemistry
  • Yusuke Kawamoto
  • ,
  • Toshikazu Bando
  • ,
  • Hiroshi Sugiyama

26
8
開始ページ
1393
終了ページ
1411
記述言語
英語
掲載種別
DOI
10.1016/j.bmc.2018.01.026
出版者・発行元
Elsevier Ltd

Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds that bind to the minor groove of double-stranded DNA in a sequence-specific manner without causing denaturation of the DNA. These compounds can be used to control gene expression and to stain specific sequences in cells. Here, we review the history, structural variations, and functional investigations of Py–Im polyamides.

リンク情報
DOI
https://doi.org/10.1016/j.bmc.2018.01.026
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29439914
ID情報
  • DOI : 10.1016/j.bmc.2018.01.026
  • ISSN : 1464-3391
  • ISSN : 0968-0896
  • PubMed ID : 29439914
  • SCOPUS ID : 85044854559

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