論文

査読有り 国際誌
2020年11月17日

DNA Alkylation of the RUNX-Binding Sequence by CBI-PI Polyamide Conjugates*.

Chemistry (Weinheim an der Bergstrasse, Germany)
  • Rina Maeda
  • ,
  • Shinji Ito
  • ,
  • Kaori Hashiya
  • ,
  • Toshikazu Bando
  • ,
  • Hiroshi Sugiyama

26
64
開始ページ
14639
終了ページ
14644
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/chem.202002166

Many types of molecular targeted drugs that inhibit cancer growth by acting on specific molecules have been developed. The runt-related transcription factor (RUNX) family, which induces cancer development by binding to a specific DNA sequence, has attracted attention as a new target for cancer treatment. We have developed Chb-M', which targets the RUNX-binding sequence. Chb-M' was developed by conjugating pyrrole-imidazole (PI) polyamides and chlorambucil as an anticancer agent. It was recently reported that Chb-M' had a remarkable anticancer effect in vivo. In this study, to explore the possibility of an alternative structure, we designed a new series of CBI-PI polyamides, in which seco-CBI was applied as a DNA-alkylating agent. We examined the characteristics of the CBI-PI polyamides targeting the RUNX-binding sequence and found that these conjugates have great potential for cancer treatment.

リンク情報
DOI
https://doi.org/10.1002/chem.202002166
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32672369
ID情報
  • DOI : 10.1002/chem.202002166
  • PubMed ID : 32672369

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